Formoterol (Foradil) and medium-high doses of inhaled corticosteroids are more effective than high doses of corticosteroids in moderate-to-severe asthma.

[1]  Tami L. Remington,et al.  Combined Budesonide/Formoterol Turbuhaler Treatment of Asthma , 2002, The Annals of pharmacotherapy.

[2]  A. Chuchalin,et al.  Evaluation of different inhaled combination therapies (EDICT): a randomised, double-blind comparison of Seretide (50/250 microg bd Diskus vs. formoterol (12 microg bd) and budesonide (800 microg bd) given concurrently (both via Turbuhaler) in patients with moderate-to-severe asthma. , 2002, Respiratory medicine.

[3]  P. Barnes,et al.  Scientific rationale for inhaled combination therapy with long-acting β2-agonists and corticosteroids , 2002, European Respiratory Journal.

[4]  A Tattersfield,et al.  Low dose inhaled budesonide and formoterol in mild persistent asthma: the OPTIMA randomized trial. , 2001, American journal of respiratory and critical care medicine.

[5]  P. Barnes,et al.  Clinical outcome of adding long-acting β-agonists to inhaled corticosteroids , 2001 .

[6]  S. Shrewsbury,et al.  Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA) , 2000, BMJ : British Medical Journal.

[7]  R. Pauwels,et al.  A long-term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high-dose budesonide in asthma. , 2000, American journal of respiratory and critical care medicine.

[8]  P. Jones,et al.  Fluticasone versus beclomethasone or budesonide for chronic asthma. , 2000, The Cochrane database of systematic reviews.

[9]  M. Aubier,et al.  Salmeterol/fluticasone propionate (50/500 microg) in combination in a Diskus inhaler (Seretide) is effective and safe in the treatment of steroid-dependent asthma. , 1999, Respiratory medicine.

[10]  N. Siafakas,et al.  Formoterol and beclomethasone versus higher dose beclomethasone as maintenance therapy in adult asthma. , 1999, The European respiratory journal.

[11]  D. Postma,et al.  Exacerbations of asthma: a descriptive study of 425 severe exacerbations. The FACET International Study Group. , 1999, American journal of respiratory and critical care medicine.

[12]  B. Lipworth Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. , 1999, Archives of internal medicine.

[13]  D. Bernstein,et al.  Concurrent use of salmeterol with inhaled corticosteroids is more effective than inhaled corticosteroid dose increases. , 1999, Allergy and asthma proceedings.

[14]  S. Yancey,et al.  The addition of salmeterol to fluticasone propionate versus increasing the dose of fluticasone propionate in patients with persistent asthma. Salmeterol Study Group. , 1999, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[15]  J. V. van Noord,et al.  Addition of salmeterol versus doubling the dose of fluticasone propionate in patients with mild to moderate asthma , 1999, Thorax.

[16]  H. Kelly Establishing a therapeutic index for the inhaled corticosteroids: part I. Pharmacokinetic/pharmacodynamic comparison of the inhaled corticosteroids. , 1998, The Journal of allergy and clinical immunology.

[17]  B. Dickey,et al.  Long-acting Inhaled β2-Agonists in Asthma Therapy , 1998 .

[18]  D. Postma,et al.  Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. , 1997, The New England journal of medicine.

[19]  J. V. van Noord,et al.  Salmeterol versus formoterol in patients with moderately severe asthma: onset and duration of action. , 1996, The European respiratory journal.

[20]  A. Woolcock,et al.  Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. , 1996, American journal of respiratory and critical care medicine.

[21]  J. Armstrong,et al.  Measuring the systemic effects of inhaled beclomethasone: timed morning urine collections compared with 24 hour specimens. , 1995, Thorax.

[22]  P. Ind,et al.  Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid , 1994, The Lancet.

[23]  T. Sandström,et al.  Time course and duration of bronchodilatation with formoterol dry powder in patients with stable asthma. , 1993, Thorax.

[24]  S J Senn,et al.  The graphical representation of clinical trials with particular reference to measurements over time. , 1990, Statistics in medicine.

[25]  S J Senn,et al.  Covariate imbalance and random allocation in clinical trials. , 1989, Statistics in medicine.

[26]  S. Pedersen,et al.  Urine cortisol excretion in children treated with high doses of inhaled corticosteroids: a comparison of budesonide and beclomethasone. , 1988, The European respiratory journal.

[27]  D. Altman Comparability of Randomised Groups , 1985 .

[28]  S. Kelsen,et al.  Salmeterol added to inhaled corticosteroid therapy is superior to doubling the dose of inhaled corticosteroids: a randomized clinical trial. , 1999, The Journal of asthma : official journal of the Association for the Care of Asthma.

[29]  P. Mulder,et al.  Comparison of salmeterol with beclomethasone in adult patients with mild persistent asthma who are already on low-dose inhaled steroids. , 1999, The Journal of asthma : official journal of the Association for the Care of Asthma.