Impact papers on aging in 2009
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L. Donehower | M. Gorospe | R. DePinho | C. Finch | N. Sharpless | D. Sinclair | A. Brunet | G. Kroemer | S. Helfand | M. Blasco | M. Serrano | D. Peeper | T. Rando | A. Nussenzweig | C. Kenyon | J. Tower | E. Verdin | P. Sassone-Corsi | K. Rudolph | J. Campisi | J. Vijg | A. Gudkov | M. Blagosklonny | J. Tilly | V. Bohr | W. Bonner | H. Osiewacz | V. Longo | V. Skulachev | A. Bartke | T. Finkel | S. Hekimi | R. Brosh | J. Karlseder | M. Hall | Tilly | Anne | Guido | Kroemer | Brunet | Toren | Finkel | Siegfried | Hekimi | S. Daniel | Peeper | L. Jonathan | Robert M. Brosh Jr
[1] M. Hansen,et al. A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in -1 , 2011 .
[2] R. Sen,et al. Faculty Opinions recommendation of Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. , 2010 .
[3] M. Roizen. Rapamycin fed late in life extends lifespan in genetically heterogenous mice , 2010 .
[4] L. Guarente,et al. Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. , 2009, Genes & development.
[5] A. Gudkov,et al. Pseudo-DNA damage response in senescent cells , 2009, Cell cycle.
[6] Yi Zeng,et al. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. , 2009, Human molecular genetics.
[7] Nektarios Tavernarakis,et al. Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol , 2009, Aging.
[8] Paolo Sassone-Corsi,et al. Metabolism and cancer: the circadian clock connection , 2009, Nature Reviews Cancer.
[9] T. Dorff,et al. Fasting and cancer treatment in humans: A case series report , 2009, Aging.
[10] M. Antoch,et al. Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1 , 2009, Aging.
[11] J. Tilly,et al. Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment , 2009, Aging.
[12] Yang Liu,et al. mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells , 2009, Science Signaling.
[13] Linda Partridge,et al. Amino acid imbalance explains extension of lifespan by dietary restriction in Drosophila , 2009, Nature.
[14] L. Chin,et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. , 2009, Cell stem cell.
[15] Alexander A. Morgan,et al. FoxO3 regulates neural stem cell homeostasis. , 2009, Cell stem cell.
[16] Seung-Jae V. Lee,et al. Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. , 2009, Cell metabolism.
[17] Y. Dobashi,et al. Polyamine-rich food decreases age-associated pathology and mortality in aged mice , 2009, Experimental Gerontology.
[18] P. Puigserver,et al. Foxo1 integrates insulin signaling with mitochondrial function in the liver , 2009, Nature Medicine.
[19] Frank Sinner,et al. Induction of autophagy by spermidine promotes longevity , 2009, Nature Cell Biology.
[20] K. Rakshit,et al. The circadian clock gene period extends healthspan in aging Drosophila melanogaster , 2009, Aging.
[21] Jeroen S. van Zon,et al. Direct cell reprogramming is a stochastic process amenable to acceleration , 2009, Nature.
[22] S. Srikantan,et al. Increased MKK4 Abundance with Replicative Senescence Is Linked to the Joint Reduction of Multiple MicroRNAs , 2009, Science Signaling.
[23] S. Tavaré,et al. Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy , 2009, Aging.
[24] Jaehyoung Cho,et al. Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain , 2009, Current Biology.
[25] Judith Campisi,et al. Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network , 2009, Proceedings of the National Academy of Sciences.
[26] S. J. Deminoff,et al. The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy , 2009, Proceedings of the National Academy of Sciences.
[27] Janet M. Thornton,et al. Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span , 2009, Science.
[28] G. Kroemer,et al. Autophagy for the avoidance of neurodegeneration. , 2009, Genes & development.
[29] K. Ocorr,et al. d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila , 2009, Aging cell.
[30] H. Kestler,et al. p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice , 2009, Nature Genetics.
[31] V. Anisimov,et al. Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats , 2009, Aging.
[32] L. Vassilev,et al. Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3 , 2009, Aging.
[33] C. Pereira,et al. Senescence impairs successful reprogramming to pluripotent stem cells. , 2009, Genes & development.
[34] Tao Wang,et al. TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease , 2009, The Journal of cell biology.
[35] L. Chodosh,et al. mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. , 2009, Cell stem cell.
[36] V. Bohr,et al. Telomeric D-loops Containing 8-Oxo-2′-deoxyguanosine Are Preferred Substrates for Werner and Bloom Syndrome Helicases and Are Bound by POT1* , 2009, The Journal of Biological Chemistry.
[37] T. Todo,et al. Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish , 2009, Cell cycle.
[38] M. Blasco,et al. Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. , 2009, Genes & development.
[39] C. Kenyon,et al. A Transcription Elongation Factor That Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans , 2009, PLoS genetics.
[40] Elizabeth A Miller,et al. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging , 2009, Proceedings of the National Academy of Sciences.
[41] D. Dixon,et al. The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase , 2009, Aging.
[42] Manuel Serrano,et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity , 2009, Nature.
[43] M. Blasco,et al. The Ink4/Arf locus is a barrier for iPS cell reprogramming , 2009, Nature.
[44] J. Utikal,et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells , 2009, Nature.
[45] Jia Hu,et al. Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism , 2009, The Journal of cell biology.
[46] J. Aris,et al. Autophagy is required for extension of yeast chronological life span by rapamycin , 2009, Autophagy.
[47] L. Donehower,et al. Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression , 2009, PloS one.
[48] M. McBurney,et al. SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol , 2009, Oncogene.
[49] P. Kapahi,et al. The hypoxic response and aging. , 2009, Cell cycle.
[50] N. Sharpless,et al. Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging , 2009, Aging cell.
[51] Pui-Yan Kwok,et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity , 2009, Aging cell.
[52] M. Gorospe,et al. Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation , 2009, Aging.
[53] N. Sharpless,et al. p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. , 2009, Developmental cell.
[54] Andrea C. Carrano,et al. A conserved ubiquitination pathway determines longevity in response to diet restriction , 2009, Nature.
[55] R. Brosh,et al. Premature aging syndrome gene WRN genetically interacts with a topoisomerase , 2009, Cell cycle.
[56] Sterling C. Johnson,et al. Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys , 2009, Science.
[57] Marco Pahor,et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.
[58] K. Tsai,et al. TAp63 prevents premature aging by promoting adult stem cell maintenance. , 2009, Cell stem cell.
[59] Hyun-Ok Song,et al. Autophagy genes mediate the effect of calcineurin on life span in C. elegans , 2009, Autophagy.
[60] D. Sinclair,et al. The ageing epigenome: Damaged beyond repair? , 2009, Ageing Research Reviews.
[61] H. Riethman,et al. Telomere length regulates ISG15 expression in human cells , 2009, Aging.
[62] H. Osiewacz,et al. Increasing organismal healthspan by enhancing mitochondrial protein quality control , 2009, Nature Cell Biology.
[63] M. Emond,et al. Disruption of Protein Kinase A in Mice Enhances Healthy Aging , 2009, PloS one.
[64] G. Atwal,et al. Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans , 2009, Proceedings of the National Academy of Sciences.
[65] M. Blagosklonny,et al. Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence , 2009, Cell cycle.
[66] M. Blagosklonny,et al. Rapamycin decelerates cellular senescence , 2009, Cell cycle.
[67] Sarah E. Brennan,et al. The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. , 2009, Cancer research.
[68] A. Sancar,et al. Circadian regulation of DNA excision repair: Implications for chrono-chemotherapy , 2009, Cell cycle.
[69] Dylan J. Sorensen,et al. Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster , 2009, Aging cell.
[70] Sheila M. Thomas,et al. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy , 2009, Aging.
[71] M. Kaeberlein,et al. Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans , 2009, Science.
[72] S. Hekimi,et al. Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-lived Mclk1+/− Mice* , 2009, The Journal of Biological Chemistry.
[73] P. Sassone-Corsi,et al. Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1 , 2009, Science.
[74] A. Bartke,et al. Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.
[75] C. Finch. Update on Slow Aging and Negligible Senescence – A Mini-Review , 2009, Gerontology.
[76] O. Wolkowitz,et al. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women , 2009, Brain, Behavior, and Immunity.
[77] Lei M. Li,et al. Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension , 2009, PLoS genetics.
[78] L. A. Obukhova,et al. An attempt to prevent senescence: a mitochondrial approach. , 2009, Biochimica et biophysica acta.
[79] P. Kapahi,et al. HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans , 2009, PLoS genetics.
[80] J. Campisi,et al. Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion , 2009, Nature Cell Biology.
[81] C. Franceschi,et al. Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population , 2009, Aging.
[82] A. Bhushan,et al. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. , 2009, Genes & development.
[83] A. Tarakhovsky,et al. Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. , 2009, Genes & development.
[84] Karen L. Mohlke,et al. INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis , 2009, PloS one.
[85] P. Klatt,et al. Anti‐aging activity of the Ink4/Arf locus , 2009, Aging cell.
[86] T. P. Neufeld,et al. An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. , 2009, Molecular biology of the cell.
[87] R. DePinho,et al. mTORC1 signaling governs hematopoietic stem cell quiescence , 2009, Cell cycle.
[88] Simon Tavaré,et al. Autophagy mediates the mitotic senescence transition. , 2009, Genes & development.
[89] C. Jung,et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. , 2009, Molecular biology of the cell.
[90] R. Bellazzi,et al. Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. , 2009, Rejuvenation research.
[91] E. Greer,et al. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans , 2009, Aging cell.
[92] Gordon J. Lithgow,et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 , 2009, Aging.
[93] L. A. Obukhova,et al. Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats , 2009, Aging.
[94] M. Blasco,et al. A p53-Dependent Response Limits Epidermal Stem Cell Functionality and Organismal Size in Mice with Short Telomeres , 2009, PloS one.
[95] J. Tower,et al. Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity , 2009, Experimental Gerontology.
[96] H. Osiewacz,et al. The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress , 2009, Aging.
[97] Bernd Epe,et al. Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice , 2009, Aging.
[98] Stefan Schreiber,et al. Association of FOXO3A variation with human longevity confirmed in German centenarians , 2009, Proceedings of the National Academy of Sciences.
[99] F. Dominici,et al. Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity , 2009, PloS one.
[100] Richard I. Morimoto,et al. Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1 , 2009, Science.
[101] G. Ruvkun,et al. Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. , 2009, Genes & development.
[102] E. Nishida,et al. Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans , 2009, Nature.
[103] S. Hekimi,et al. Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans , 2009, PLoS genetics.
[104] Christophe E. Redon,et al. Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells , 2009, Aging.
[105] R. Brosh,et al. WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3 , 2009, Aging.
[106] M. D'Angelo,et al. Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells , 2009, Cell.
[107] Kevin M. McBride,et al. The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1* , 2009, Journal of Biological Chemistry.
[108] L. Donehower. Longevity regulation in flies: A role for p53 , 2009, Aging.
[109] G. Shadel,et al. Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density , 2009, Aging.
[110] S. Guan,et al. SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair , 2009, Aging.
[111] C. Epstein,et al. The overexpression of major antioxidant enzymes does not extend the lifespan of mice , 2008, Aging cell.
[112] S. Helfand,et al. dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster , 2008, Aging.
[113] Nancy E. Adler,et al. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men , 2008, Aging.
[114] Ho-Joon Lee,et al. Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival , 2008, Aging.
[115] Nektarios Tavernarakis,et al. The effects of p53 on whole organism longevity are mediated by autophagy , 2008, Autophagy.
[116] M. Driscoll,et al. A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans , 2008, PLoS genetics.