Impact papers on aging in 2009

The editorial board of Aging reviews research papers published in 2009, which they believe have or will have a significant impact on aging research. Among many others, the topics include genes that accelerate aging or in contrast promote longevity in model organisms, DNA damage responses and telomeres, molecular mechanisms of life span extension by calorie restriction and pharmacologic interventions into aging. The emerging message in 2009 is that aging is not random but determined by a genetically-regulated longevity network and can be decelerated both genetically and pharmacologically.

[1]  M. Hansen,et al.  A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in -1 , 2011 .

[2]  R. Sen,et al.  Faculty Opinions recommendation of Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. , 2010 .

[3]  M. Roizen.  Rapamycin fed late in life extends lifespan in genetically heterogenous mice , 2010 .

[4]  L. Guarente,et al.  Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction. , 2009, Genes & development.

[5]  A. Gudkov,et al.  Pseudo-DNA damage response in senescent cells , 2009, Cell cycle.

[6]  Yi Zeng,et al.  Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. , 2009, Human molecular genetics.

[7]  Nektarios Tavernarakis,et al.  Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol , 2009, Aging.

[8]  Paolo Sassone-Corsi,et al.  Metabolism and cancer: the circadian clock connection , 2009, Nature Reviews Cancer.

[9]  T. Dorff,et al.  Fasting and cancer treatment in humans: A case series report , 2009, Aging.

[10]  M. Antoch,et al.  Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1 , 2009, Aging.

[11]  J. Tilly,et al.  Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment , 2009, Aging.

[12]  Yang Liu,et al.  mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells , 2009, Science Signaling.

[13]  Linda Partridge,et al.  Amino acid imbalance explains extension of lifespan by dietary restriction in Drosophila , 2009, Nature.

[14]  L. Chin,et al.  FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. , 2009, Cell stem cell.

[15]  Alexander A. Morgan,et al.  FoxO3 regulates neural stem cell homeostasis. , 2009, Cell stem cell.

[16]  Seung-Jae V. Lee,et al.  Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. , 2009, Cell metabolism.

[17]  Y. Dobashi,et al.  Polyamine-rich food decreases age-associated pathology and mortality in aged mice , 2009, Experimental Gerontology.

[18]  P. Puigserver,et al.  Foxo1 integrates insulin signaling with mitochondrial function in the liver , 2009, Nature Medicine.

[19]  Frank Sinner,et al.  Induction of autophagy by spermidine promotes longevity , 2009, Nature Cell Biology.

[20]  K. Rakshit,et al.  The circadian clock gene period extends healthspan in aging Drosophila melanogaster , 2009, Aging.

[21]  Jeroen S. van Zon,et al.  Direct cell reprogramming is a stochastic process amenable to acceleration , 2009, Nature.

[22]  S. Srikantan,et al.  Increased MKK4 Abundance with Replicative Senescence Is Linked to the Joint Reduction of Multiple MicroRNAs , 2009, Science Signaling.

[23]  S. Tavaré,et al.  Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy , 2009, Aging.

[24]  Jaehyoung Cho,et al.  Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain , 2009, Current Biology.

[25]  Judith Campisi,et al.  Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network , 2009, Proceedings of the National Academy of Sciences.

[26]  S. J. Deminoff,et al.  The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy , 2009, Proceedings of the National Academy of Sciences.

[27]  Janet M. Thornton,et al.  Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span , 2009, Science.

[28]  G. Kroemer,et al.  Autophagy for the avoidance of neurodegeneration. , 2009, Genes & development.

[29]  K. Ocorr,et al.  d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila , 2009, Aging cell.

[30]  H. Kestler,et al.  p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice , 2009, Nature Genetics.

[31]  V. Anisimov,et al.  Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats , 2009, Aging.

[32]  L. Vassilev,et al.  Reduced transcriptional activity in the p53 pathway of senescent cells revealed by the MDM2 antagonist nutlin-3 , 2009, Aging.

[33]  C. Pereira,et al.  Senescence impairs successful reprogramming to pluripotent stem cells. , 2009, Genes & development.

[34]  Tao Wang,et al.  TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease , 2009, The Journal of cell biology.

[35]  L. Chodosh,et al.  mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging. , 2009, Cell stem cell.

[36]  V. Bohr,et al.  Telomeric D-loops Containing 8-Oxo-2′-deoxyguanosine Are Preferred Substrates for Werner and Bloom Syndrome Helicases and Are Bound by POT1* , 2009, The Journal of Biological Chemistry.

[37]  T. Todo,et al.  Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish , 2009, Cell cycle.

[38]  M. Blasco,et al.  Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice. , 2009, Genes & development.

[39]  C. Kenyon,et al.  A Transcription Elongation Factor That Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans , 2009, PLoS genetics.

[40]  Elizabeth A Miller,et al.  Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging , 2009, Proceedings of the National Academy of Sciences.

[41]  D. Dixon,et al.  The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase , 2009, Aging.

[42]  Manuel Serrano,et al.  A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity , 2009, Nature.

[43]  M. Blasco,et al.  The Ink4/Arf locus is a barrier for iPS cell reprogramming , 2009, Nature.

[44]  J. Utikal,et al.  Immortalization eliminates a roadblock during cellular reprogramming into iPS cells , 2009, Nature.

[45]  Jia Hu,et al.  Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism , 2009, The Journal of cell biology.

[46]  J. Aris,et al.  Autophagy is required for extension of yeast chronological life span by rapamycin , 2009, Autophagy.

[47]  L. Donehower,et al.  Timed Somatic Deletion of p53 in Mice Reveals Age-Associated Differences in Tumor Progression , 2009, PloS one.

[48]  M. McBurney,et al.  SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol , 2009, Oncogene.

[49]  P. Kapahi,et al.  The hypoxic response and aging. , 2009, Cell cycle.

[50]  N. Sharpless,et al.  Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging , 2009, Aging cell.

[51]  Pui-Yan Kwok,et al.  Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity , 2009, Aging cell.

[52]  M. Gorospe,et al.  Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation , 2009, Aging.

[53]  N. Sharpless,et al.  p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. , 2009, Developmental cell.

[54]  Andrea C. Carrano,et al.  A conserved ubiquitination pathway determines longevity in response to diet restriction , 2009, Nature.

[55]  R. Brosh,et al.  Premature aging syndrome gene WRN genetically interacts with a topoisomerase , 2009, Cell cycle.

[56]  Sterling C. Johnson,et al.  Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys , 2009, Science.

[57]  Marco Pahor,et al.  Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.

[58]  K. Tsai,et al.  TAp63 prevents premature aging by promoting adult stem cell maintenance. , 2009, Cell stem cell.

[59]  Hyun-Ok Song,et al.  Autophagy genes mediate the effect of calcineurin on life span in C. elegans , 2009, Autophagy.

[60]  D. Sinclair,et al.  The ageing epigenome: Damaged beyond repair? , 2009, Ageing Research Reviews.

[61]  H. Riethman,et al.  Telomere length regulates ISG15 expression in human cells , 2009, Aging.

[62]  H. Osiewacz,et al.  Increasing organismal healthspan by enhancing mitochondrial protein quality control , 2009, Nature Cell Biology.

[63]  M. Emond,et al.  Disruption of Protein Kinase A in Mice Enhances Healthy Aging , 2009, PloS one.

[64]  G. Atwal,et al.  Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans , 2009, Proceedings of the National Academy of Sciences.

[65]  M. Blagosklonny,et al.  Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence , 2009, Cell cycle.

[66]  M. Blagosklonny,et al.  Rapamycin decelerates cellular senescence , 2009, Cell cycle.

[67]  Sarah E. Brennan,et al.  The mRNA-destabilizing protein tristetraprolin is suppressed in many cancers, altering tumorigenic phenotypes and patient prognosis. , 2009, Cancer research.

[68]  A. Sancar,et al.  Circadian regulation of DNA excision repair: Implications for chrono-chemotherapy , 2009, Cell cycle.

[69]  Dylan J. Sorensen,et al.  Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster , 2009, Aging cell.

[70]  Sheila M. Thomas,et al.  Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy , 2009, Aging.

[71]  M. Kaeberlein,et al.  Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans , 2009, Science.

[72]  S. Hekimi,et al.  Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-lived Mclk1+/− Mice* , 2009, The Journal of Biological Chemistry.

[73]  P. Sassone-Corsi,et al.  Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1 , 2009, Science.

[74]  A. Bartke,et al.  Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[75]  C. Finch.  Update on Slow Aging and Negligible Senescence – A Mini-Review , 2009, Gerontology.

[76]  O. Wolkowitz,et al.  Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women , 2009, Brain, Behavior, and Immunity.

[77]  Lei M. Li,et al.  Tor1/Sch9-Regulated Carbon Source Substitution Is as Effective as Calorie Restriction in Life Span Extension , 2009, PLoS genetics.

[78]  L. A. Obukhova,et al.  An attempt to prevent senescence: a mitochondrial approach. , 2009, Biochimica et biophysica acta.

[79]  P. Kapahi,et al.  HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans , 2009, PLoS genetics.

[80]  J. Campisi,et al.  Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion , 2009, Nature Cell Biology.

[81]  C. Franceschi,et al.  Identification of single nucleotide polymorphisms in the p21 (CDKN1A) gene and correlations with longevity in the Italian population , 2009, Aging.

[82]  A. Bhushan,et al.  Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. , 2009, Genes & development.

[83]  A. Tarakhovsky,et al.  Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. , 2009, Genes & development.

[84]  Karen L. Mohlke,et al.  INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis , 2009, PloS one.

[85]  P. Klatt,et al.  Anti‐aging activity of the Ink4/Arf locus , 2009, Aging cell.

[86]  T. P. Neufeld,et al.  An Atg1/Atg13 complex with multiple roles in TOR-mediated autophagy regulation. , 2009, Molecular biology of the cell.

[87]  R. DePinho,et al.  mTORC1 signaling governs hematopoietic stem cell quiescence , 2009, Cell cycle.

[88]  Simon Tavaré,et al.  Autophagy mediates the mitotic senescence transition. , 2009, Genes & development.

[89]  C. Jung,et al.  ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. , 2009, Molecular biology of the cell.

[90]  R. Bellazzi,et al.  Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. , 2009, Rejuvenation research.

[91]  E. Greer,et al.  Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans , 2009, Aging cell.

[92]  Gordon J. Lithgow,et al.  MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 , 2009, Aging.

[93]  L. A. Obukhova,et al.  Mitochondria-targeted antioxidant SkQ1 inhibits age-dependent involution of the thymus in normal and senescence-prone rats , 2009, Aging.

[94]  M. Blasco,et al.  A p53-Dependent Response Limits Epidermal Stem Cell Functionality and Organismal Size in Mice with Short Telomeres , 2009, PloS one.

[95]  J. Tower,et al.  Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity , 2009, Experimental Gerontology.

[96]  H. Osiewacz,et al.  The S-adenosylmethionine dependent O-methyltransferase PaMTH1: a longevity assurance factor protecting Podospora anserina against oxidative stress , 2009, Aging.

[97]  Bernd Epe,et al.  Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice , 2009, Aging.

[98]  Stefan Schreiber,et al.  Association of FOXO3A variation with human longevity confirmed in German centenarians , 2009, Proceedings of the National Academy of Sciences.

[99]  F. Dominici,et al.  Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity , 2009, PloS one.

[100]  Richard I. Morimoto,et al.  Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1 , 2009, Science.

[101]  G. Ruvkun,et al.  Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. , 2009, Genes & development.

[102]  E. Nishida,et al.  Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans , 2009, Nature.

[103]  S. Hekimi,et al.  Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans , 2009, PLoS genetics.

[104]  Christophe E. Redon,et al.  Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells , 2009, Aging.

[105]  R. Brosh,et al.  WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3 , 2009, Aging.

[106]  M. D'Angelo,et al.  Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells , 2009, Cell.

[107]  Kevin M. McBride,et al.  The Anti-neurodegeneration Drug Clioquinol Inhibits the Aging-associated Protein CLK-1* , 2009, Journal of Biological Chemistry.

[108]  L. Donehower.  Longevity regulation in flies: A role for p53 , 2009, Aging.

[109]  G. Shadel,et al.  Extension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density , 2009, Aging.

[110]  S. Guan,et al.  SIRT6 stabilizes DNA-dependent Protein Kinase at chromatin for DNA double-strand break repair , 2009, Aging.

[111]  C. Epstein,et al.  The overexpression of major antioxidant enzymes does not extend the lifespan of mice , 2008, Aging cell.

[112]  S. Helfand,et al.  dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster , 2008, Aging.

[113]  Nancy E. Adler,et al.  The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men , 2008, Aging.

[114]  Ho-Joon Lee,et al.  Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival , 2008, Aging.

[115]  Nektarios Tavernarakis,et al.  The effects of p53 on whole organism longevity are mediated by autophagy , 2008, Autophagy.

[116]  M. Driscoll,et al.  A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans , 2008, PLoS genetics.