论文信息 - Is voltage-dependent synaptic transmission in NMDA receptors a robust mechanism for working memory?

Is voltage-dependent synaptic transmission in NMDA receptors a robust mechanism for working memory?

Abstract The voltage-dependent synaptic transmission in NMDA receptors had been demonstrated to provide persistence of a stimulated activity pattern independent of any form of synaptic plasticity (Nature Neurosci. 1 (4) (1998) 273). This possible mechanism for working memory, however, relied on some unrealistic conditions. The model requires a dominance of NMDA-mediated over AMPA-mediated currents that is unlikely. Furthermore, as we will show in this paper the mechanism is not robust against realistic amounts of noise. We propose a modified model in which short-time memory of a few hundred milliseconds is maintained by input-driven NMDA currents even in the presence of high levels of noise and AMPA currents.

[1] A. Malhotra,et al. Effects of Ketamine on Thought Disorder, Working Memory, and Semantic Memory in Healthy Volunteers , 1998, Biological Psychiatry.

[2] Friedrich T. Sommer,et al. Coexistence of short and long term memory in a model network of realistic neurons , 2001, Neurocomputing.

[3] J. Fellous,et al. A role for NMDA-receptor channels in working memory , 1998, Nature Neuroscience.

[4] John Rinzel,et al. Intrinsic and network rhythmogenesis in a reduced traub model for CA3 neurons , 1995, Journal of Computational Neuroscience.

[5] X. Wang,et al. Synaptic Basis of Cortical Persistent Activity: the Importance of NMDA Receptors to Working Memory , 1999, The Journal of Neuroscience.