Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

R. Collins | R. Peto | Xian-ping Wu | Liyuan Zhou | D. Bennett | L. Fan | B. Nordestgaard | R. Clarke | Zhengming Chen | Junshi Chen | Yu Guo | Liming Li | Z. Pang | M. Holmes | S. Lewington | R. Hu | Chunmei Wang | C. Kartsonaki | Tao Huang | Qiang Sun | Ziyan Guo | Huimei Li | R. Gao | Xiao Han | P. Sherliker | Libo Zhang | J. Radhakrishnan | Canqing Yu | Z. Bian | Ling Yang | I. Millwood | R. Walters | Yiping Chen | J. Lv | Ningyu Chen | Liangcai Ma | I. Turnbull | Hao Zhang | Kuang Lin | C. Hou | Ming Wu | C. Ellervik | Jinyan Chen | X. Tian | O. Kurmi | Y. Liu | R. Boxall | Hua Zhang | Ling Kong | Jinyi Zhou | Jie Yang | Yongmei Liu | Xiaofang Chen | Jian Su | Shaojie Wang | Xukui Zhang | Xin Xu | Q. Kang | Min Yu | Zhen-zhu Tang | Yong-lin Zhou | Yajing Zang | H. Du | Chen Hu | Dan Wang | Xiaohuan Wang | S. Afzal | Yuelong Huang | C. Dong | Peng-fei Ge | X. Ren | Liuping Wei | Huilin Liu | Pan He | Yongmei Liu | W. Hou | Yilei Li | F. Ning | R. Tao | Tao Wang | Z. Fu | Jinhuai Meng | Yulian Gao | Shanpeng Li | Qijun Gu | Ping Wang | Chao Liu | Feifei Li | Yi-Heng Hu | Liang Cheng | A. Hacker | D. Avery | Shuo Zhang | Bo Yu | Fang Liu | S. Sansome | Ying Huang | Ningmei Zhang | P. Pei | Xiaoming Yang | Yumei Chang | S. Gilbert | A. Iona | Qunhua Nie | P. Ryder | R. Sohoni | Becky Stevens | Lin Wang | N. Wright | Qilian Jiang | J. Lan | Mingqiang Li | Rong Pan | Enke Mao | Ximin Hu | M. Weng | Shukuan Wu | Xue Zhou | Yanjie Li | Qinai Xu | Liang Chang | Ding Zhang | Tianyou He | Huarong Sun | Biyun Chen | Qiaohua Xu | Huajun Long | Jing-chao Liu | Aiyu Tang | Jun Zhang | Ranran Du | Yaoming Zhai | Silu Lv | Junzheng Wang | Jianguo Li | Jiaqiu Liu | G. Luo | Xunfu Zhong | D. Pan | K. Xie | Hao Wang | Weiwei Zhou | Yunlong Tan | Yulu Qin | M. Zeng | Zhe Qiu | M. Hill | Yidan Zhang | Yan Fu | Jianrong Jin | Yan Lu | Hui He | Huifang Wu | Liqiu Yang | Garry Lancaster | Jenny T. Wang | Hui Zhang | Shixian Feng | Xianzhi Li | Zhifang Fu | Lingli Chen | Li Yin | Zhenwang Fu | J. McDonnell | G. Jiang | D. Schmidt | Canqing Yu | Xiaohui Sun | N. Chen | Sisi Wang | Xiaoping Wang | Y. Qian | J. Lv | Zhendong Guo | Hua Zhang | Xi Zhang | R. Kerosi | Fanwen Meng | G. Zhou | Junshi Zhengming Robert Rory Yu Liming Jun Richard Robin Chen Chen Clarke Collins Guo Li Lv Peto Wal | Junshi Zhengming Robert Rory Yu Liming Jun Richard Robin Chen Chen Clarke Collins Guo Li Lv Peto Wa | Z. Fu | X. Zhong | M. Yu | Ruth Boxall | Paul Ryder | Rajani Sohoni | Yiping Chen | Liming Li | Junzheng Wang | Zhengming Chen | G. Lancaster | Yu Guo | Xiaohua Wang | Hui Zhang | R. Clarke | Min Yu | Yun Liu | Hao Zhang

[1]  J. Manson,et al.  Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease , 2019, The New England journal of medicine.

[2]  D. Sorriento,et al.  Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications , 2018, Oxidative medicine and cellular longevity.

[3]  B. Nordestgaard,et al.  From genome-wide association studies to Mendelian randomization: novel opportunities for understanding cardiovascular disease causality, pathogenesis, prevention, and treatment. , 2018, Cardiovascular research.

[4]  Y. Tintut,et al.  Steroid Hormone Vitamin D: Implications for Cardiovascular Disease. , 2018, Circulation research.

[5]  M. McCarthy,et al.  Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults , 2018, PLoS medicine.

[6]  W. März,et al.  Vitamin D supplementation and lipoprotein metabolism: A randomized controlled trial. , 2018, Journal of clinical lipidology.

[7]  B. Neale,et al.  Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases , 2018, Nature Genetics.

[8]  Changwei Li,et al.  Childhood BMI and Adult Type 2 Diabetes, Coronary Artery Diseases, Chronic Kidney Disease, and Cardiometabolic Traits: A Mendelian Randomization Analysis , 2018, Diabetes Care.

[9]  M. Illario,et al.  Vitamin D, parathyroid hormone and cardiovascular risk: the good, the bad and the ugly , 2017, Journal of cardiovascular medicine.

[10]  Audrey Y. Chu,et al.  Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies. , 2018, Clinical chemistry.

[11]  D. Cohen,et al.  Publisher's Note , 2017, Neuroscience & Biobehavioral Reviews.

[12]  J. Gummert,et al.  Effect of vitamin D on all-cause mortality in heart failure (EVITA): a 3-year randomized clinical trial with 4000 IU vitamin D daily , 2017, European heart journal.

[13]  A. Quyyumi,et al.  Vitamin D and Cardiovascular Disease: Controversy Unresolved. , 2017, Journal of the American College of Cardiology.

[14]  Tanya M. Teslovich,et al.  An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans , 2017, Diabetes.

[15]  Elizabeth L. Barry,et al.  Vitamin D Receptor Genotype, Vitamin D3 Supplementation, and Risk of Colorectal Adenomas: A Randomized Clinical Trial , 2017, JAMA oncology.

[16]  B. Nordestgaard,et al.  Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study , 2017, British Medical Journal.

[17]  M. Taghizadeh,et al.  The effects of vitamin D and omega-3 fatty acid co-supplementation on glycemic control and lipid concentrations in patients with gestational diabetes. , 2017, Journal of clinical lipidology.

[18]  J. Manson,et al.  Effects of Calcium, Vitamin D, and Hormone Therapy on Cardiovascular Disease Risk Factors in the Women's Health Initiative: A Randomized Controlled Trial. , 2017, Obstetrics and gynecology.

[19]  M. Gulati,et al.  Lack of Evidence Linking Calcium With or Without Vitamin D Supplementation to Cardiovascular Disease in Generally Healthy Adults: A Clinical Guideline From the National Osteoporosis Foundation and the American Society for Preventive Cardiology , 2016, Annals of Internal Medicine.

[20]  W. März,et al.  Vitamin D and cardiovascular disease prevention , 2016, Nature Reviews Cardiology.

[21]  J. Manson,et al.  Low birthweight and risk of type 2 diabetes: a Mendelian randomisation study , 2016, Diabetologia.

[22]  G. Hitman,et al.  Effects of vitamin D2 or D3 supplementation on glycaemic control and cardiometabolic risk among people at risk of type 2 diabetes: results of a randomized double‐blind placebo‐controlled trial , 2016, Diabetes, obesity & metabolism.

[23]  Shoaib Afzal,et al.  No evidence that genetically reduced 25-hydroxyvitamin D is associated with increased risk of ischaemic heart disease or myocardial infarction: a Mendelian randomization study. , 2015, International journal of epidemiology.

[24]  G. Davey Smith,et al.  Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression , 2015, International journal of epidemiology.

[25]  S. Bojesen,et al.  Genetically low vitamin D concentrations and increased mortality: mendelian randomisation analysis in three large cohorts , 2014, BMJ : British Medical Journal.

[26]  B. Nordestgaard,et al.  Elevated Remnant Cholesterol in 25-Hydroxyvitamin D Deficiency in the General Population: Mendelian Randomization Study , 2014, Circulation. Cardiovascular genetics.

[27]  I. Njølstad,et al.  No Effect of High-Dose Vitamin D Supplementation on Glycemic Status or Cardiovascular Risk Factors in Subjects With Prediabetes , 2014, Diabetes Care.

[28]  Ross M. Fraser,et al.  Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study , 2014, The lancet. Diabetes & endocrinology.

[29]  J. Wetterslev,et al.  Vitamin D supplementation for prevention of cancer in adults. , 2014, The Cochrane database of systematic reviews.

[30]  W. Rathmann,et al.  Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States , 2014, BMJ : British Medical Journal.

[31]  O. Franco,et al.  Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies , 2014, BMJ : British Medical Journal.

[32]  S. Bojesen,et al.  Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study. , 2014, The lancet. Diabetes & endocrinology.

[33]  J. Wetterslev,et al.  Vitamin D supplementation for prevention of mortality in adults. , 2011, The Cochrane database of systematic reviews.

[34]  B. Nordestgaard,et al.  Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. , 2013, JAMA.

[35]  S. Bojesen,et al.  Low 25-hydroxyvitamin D and risk of type 2 diabetes: a prospective cohort study and metaanalysis. , 2013, Clinical chemistry.

[36]  T. Spector,et al.  Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts , 2013, PLoS medicine.

[37]  H. Boeing,et al.  Dietary, lifestyle, and genetic determinants of vitamin D status: a cross-sectional analysis from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study , 2013, European Journal of Nutrition.

[38]  B. Nordestgaard,et al.  25-Hydroxyvitamin D Levels and Risk of Ischemic Heart Disease, Myocardial Infarction, and Early Death: Population-Based Study and Meta-Analyses of 18 and 17 Studies , 2012, Arteriosclerosis, thrombosis, and vascular biology.

[39]  Elina Hyppönen,et al.  Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis , 2012, The American journal of clinical nutrition.

[40]  R. Jorde,et al.  Vitamin D, Insulin Secretion, Sensitivity, and Lipids , 2011, Diabetes.

[41]  R. Jorde,et al.  Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. , 2011, Progress in lipid research.

[42]  Daniel L. Koller,et al.  Common genetic determinants of vitamin D insufficiency: a genome-wide association study , 2010, The Lancet.

[43]  William Wheeler,et al.  Genome-wide association study of circulating vitamin D levels , 2010, Human molecular genetics.

[44]  Hannah R Rothstein,et al.  A basic introduction to fixed‐effect and random‐effects models for meta‐analysis , 2010, Research synthesis methods.

[45]  J. Manson,et al.  Systematic Review: Vitamin D and Calcium Supplementation in Prevention of Cardiovascular Events , 2010, Annals of Internal Medicine.

[46]  O. Franco,et al.  Plasma 25-Hydroxyvitamin D Concentration and Metabolic Syndrome Among Middle-Aged and Elderly Chinese Individuals , 2009, Diabetes Care.

[47]  Michael J. Pencina,et al.  Vitamin D Deficiency and Risk of Cardiovascular Disease , 2008, Circulation.

[48]  S. Ebrahim,et al.  'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? , 2003, International journal of epidemiology.