Intracellular signaling by 14-hydroxy-4,14-retro-retinol.

In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.

[1]  A. Myc,et al.  Differences in the action and metabolism between retinol and retinoic acid in B lymphocytes , 1991, The Journal of cell biology.

[2]  R. Evans,et al.  Nuclear receptor that identifies a novel retinoic acid response pathway , 1990, Nature.

[3]  B. Chait,et al.  Retinol is essential for growth of activated human B cells , 1990, The Journal of experimental medicine.

[4]  Pierre Chambon,et al.  A human retinoic acid receptor which belongs to the family of nuclear receptors , 1987, Nature.

[5]  V. Giguère,et al.  Identification of a receptor for the morphogen retinoic acid , 1987, Nature.

[6]  K. Nakanishi,et al.  GENERAL METHOD FOR DETERMINING ABSOLUTE CONFIGURATION OF ACYCLIC ALLYLIC ALCOHOLS , 1982 .

[7]  G. Peck,et al.  Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials. , 1982, Clinical chemistry.

[8]  F. Chytil,et al.  Cellular retinol-binding protein from rat liver. Purification and characterization. , 1978, The Journal of biological chemistry.

[9]  G. Fex,et al.  Purification of a bovine counterpart to human prealbumin and its interaction with a bovine retinol-binding protein. , 1977, Biochimica et biophysica acta.

[10]  D. Oesterhelt,et al.  Studies on the retinal-protein interaction in bacteriorhodopsin. , 1977, European journal of biochemistry.

[11]  A. Beecham.  The influence of allylic oxygen on the π → π* CD of certain chromophores , 1971 .

[12]  G. Wald.  The molecular basis of visual excitation. , 1968, Nature.

[13]  P. Pollak,et al.  Conversion of Vitamin A Acetate to Retrovitamin A Acetate , 1955 .

[14]  W. Oroshnik,et al.  Synthesis of Polyenes. I. Retrovitamin A Methyl Ether. Spectral Relationships between the β-Ionylidene and Retroionylidene Series , 1952 .