Factors affecting the efficacy of cyclosporin A therapy for refractory ulcerative colitis

Background and Aims:  Cyclosporin A (CSA), an immunosuppressive agent, is highly efficacious in patients with refractory ulcerative colitis (UC). We retrospectively investigated patients with refractory UC treated with CSA therapy to elucidate the efficacy and the prognostic factors.

[1]  K Rowland-Yeo,et al.  Prediction of in vivo drug clearance from in vitro data. II: Potential inter-ethnic differences , 2006, Xenobiotica; the fate of foreign compounds in biological systems.

[2]  R. Modigliani,et al.  Infliximab for refractory ulcerative colitis or indeterminate colitis: an open‐label multicentre study , 2003, Alimentary pharmacology & therapeutics.

[3]  A. Forbes,et al.  Infliximab in moderately severe glucocorticoid resistant ulcerative colitis: a randomised controlled trial , 2003, Gut.

[4]  R. Cohen,et al.  A comparison of the quality of life in patients with severe ulcerative colitis after total colectomy versus medical treatment with intravenous cyclosporin. , 1999, Inflammatory bowel diseases.

[5]  W. Sandborn A Critical Review of Cyclosporine Therapy in Inflammatory Bowel Disease , 1995 .

[6]  S. Hanauer,et al.  Cyclosporine in severe ulcerative colitis refractory to steroid therapy. , 1994, The New England journal of medicine.

[7]  G. Actis,et al.  Continuously Infused Cyclosporine at Low Dose Is Sufficient to Avoid Emergency Colectomy in Acute Attacks of Ulcerative Colitis Without the Need for High‐Dose Steroids , 1993, Journal of clinical gastroenterology.

[8]  M. Selgrade,et al.  Correlation between chemical suppression of natural killer cell activity in mice and susceptibility to cytomegalovirus: rationale for applying murine cytomegalovirus as a host resistance model and for interpreting immunotoxicity testing in terms of risk of disease. , 1992, Journal of toxicology and environmental health.

[9]  T. Yao,et al.  An index of disease activity in patients with ulcerative colitis. , 1992, The American journal of gastroenterology.