Morphometric differences in the Heschl's gyrus of hearing impaired and normal hearing infants.

This study investigates the morphometry of Heschl's gyrus and its included primary auditory cortex (PAC) in hearing impaired (HI) and normal hearing (NH) infants. Fourty-two infants, age 8-19 months, with NH (n = 26) or hearing impairment (n = 16) were studied using high-resolution 3D magnetic resonance imaging. Gray matter (GM) and white matter (WM) volumes were obtained using software for automatic brain imaging segmentation to estimate the volume of each tissue within manually defined regions for the anterior portion of Heschl's gyrus (aHG) in each individual subject, transformed to an infant brain template space. Interactions among group (HI, NH), tissue type (GM, WM), and hemisphere (left, right) were examined using analysis of variance. Whole-brain voxel-based morphometry was utilized to explore volume differences between groups across the entire brain. The HI group showed increased GM and decreased WM in aHG compared with the NH group; likely effects of auditory deprivation. The HI group did not exhibit their typical L > R asymmetry pattern that the NH group showed. Increased GM in aHG in HI infants may represent abnormal cortical development in PAC as seen in animal models of sensory deprivation. Lower WM volume is consistent with studies with deaf adults.

[1]  Patrícia Maria Sens,et al.  Participation of the cerebellum in auditory processing. , 2007, Brazilian journal of otorhinolaryngology.

[2]  P. Huttenlocher.  Synaptic density in human frontal cortex - developmental changes and effects of aging. , 1979, Brain research.

[3]  D. Shibata,et al.  Differences in brain structure in deaf persons on MR imaging studied with voxel-based morphometry. , 2007, AJNR. American journal of neuroradiology.

[4]  F. Linthicum,et al.  The human auditory system: A timeline of development , 2007, International journal of audiology.

[5]  G. Egan,et al.  Structural variability of human auditory cortices: does it matter? , 2007 .

[6]  P. Huttenlocher,et al.  Regional differences in synaptogenesis in human cerebral cortex , 1997, The Journal of comparative neurology.

[7]  Robert J Zatorre,et al.  The morphometry of auditory cortex in the congenitally deaf measured using MRI , 2003, NeuroImage.

[8]  Derek M. Houston,et al.  Language skills of profoundly deaf children who received cochlear implants under 12 months of age: a preliminary study , 2008, Acta oto-laryngologica.

[9]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[10]  M. Eckert,et al.  Speech Recognition in Younger and Older Adults: A Dependency on Low-Level Auditory Cortex , 2009, The Journal of Neuroscience.

[11]  R. Frackowiak,et al.  Functional plasticity of language-related brain areas after cochlear implantation. , 2001, Brain : a journal of neurology.

[12]  E. Glaser,et al.  Neonatal deafening alters nonpyramidal dendrite orientation in auditory cortex: A computer microscope study in the rabbit , 1988, The Journal of comparative neurology.

[13]  Scott Holland,et al.  Infant brain probability templates for MRI segmentation and normalization , 2008, NeuroImage.

[14]  M. Gazzaniga,et al.  The new cognitive neurosciences , 2000 .

[15]  Mijna Hadders-Algra,et al.  Ontogeny of the human central nervous system: what is happening when? , 2006, Early human development.

[16]  Larry Gates,et al.  Distinct and shared cortical regions of the human brain activated by pictorial depictions versus verbal descriptions: an fMRI study , 2005, NeuroImage.

[17]  K. McGraw,et al.  Forming inferences about some intraclass correlation coefficients. , 1996 .

[18]  P. Goldman-Rakic,et al.  Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. , 1986, Science.

[19]  Rosa H. Huang,et al.  Projections from the cochlear nucleus to the cerebellum , 1982, Brain Research.

[20]  Hanna Damasio,et al.  A morphometric analysis of auditory brain regions in congenitally deaf adults , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Patrícia Maria Sens,et al.  Participação do cerebelo no processamento auditivo , 2007 .

[22]  Suzanne E. Welcome,et al.  Longitudinal Mapping of Cortical Thickness and Brain Growth in Normal Children , 2022 .

[23]  D. Winfield.  The postnatal development of synapses in the visual cortex of the cat and the effects of eyelid closure , 1981, Brain Research.

[24]  J. Fleiss,et al.  Intraclass correlations: uses in assessing rater reliability. , 1979, Psychological bulletin.

[25]  Suzanne E. Welcome,et al.  Mapping cortical change across the human life span , 2003, Nature Neuroscience.

[26]  A Kral,et al.  Postnatal cortical development in congenital auditory deprivation. , 2005, Cerebral cortex.

[27]  Antonio Y Hardan,et al.  An MRI study of increased cortical thickness in autism. , 2006, The American journal of psychiatry.

[28]  D. Winfield.  The postnatal development of synapses in the different laminae of the visual cortex in the normal kitten and in kittens with eyelid suture. , 1983, Brain research.

[29]  Jean K. Moore,et al.  Cytoarchitectural and Axonal Maturation in Human Auditory Cortex , 2001, Journal of the Association for Research in Otolaryngology.

[30]  R. Kikinis,et al.  Planum temporale and Heschl gyrus volume reduction in schizophrenia: a magnetic resonance imaging study of first-episode patients. , 2000, Archives of general psychiatry.

[31]  Meritxell Bach Cuadra,et al.  Comparison and validation of tissue modelization and statistical classification methods in T1-weighted MR brain images , 2005, IEEE Transactions on Medical Imaging.

[32]  Karl J. Friston,et al.  Unified segmentation , 2005, NeuroImage.

[33]  Thomas F. Nugent,et al.  Dynamic mapping of human cortical development during childhood through early adulthood. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  A. Galaburda,et al.  Topographical variation of the human primary cortices: implications for neuroimaging, brain mapping, and neurobiology. , 1993, Cerebral cortex.

[35]  Eric Courchesne,et al.  Cerebral Lobes in Autism: Early Hyperplasia and Abnormal Age Effects , 2002, NeuroImage.

[36]  Vanessa Sluming,et al.  Heschl gyrus and its included primary auditory cortex: Structural MRI studies in healthy and diseased subjects , 2008, Journal of magnetic resonance imaging : JMRI.

[37]  P. Morosan,et al.  Probabilistic Mapping and Volume Measurement of Human Primary Auditory Cortex , 2001, NeuroImage.

[38]  M. Scherg,et al.  Morphology of Heschl's gyrus reflects enhanced activation in the auditory cortex of musicians , 2002, Nature Neuroscience.

[39]  Angela R Laird,et al.  Cerebellum and auditory function: An ALE meta‐analysis of functional neuroimaging studies , 2005, Human brain mapping.

[40]  Alan C. Evans,et al.  Interhemispheric anatomical differences in human primary auditory cortex: probabilistic mapping and volume measurement from magnetic resonance scans. , 1996, Cerebral cortex.

[41]  A. Toga,et al.  Mapping Continued Brain Growth and Gray Matter Density Reduction in Dorsal Frontal Cortex: Inverse Relationships during Postadolescent Brain Maturation , 2001, The Journal of Neuroscience.

[42]  N. T. McMullen,et al.  Auditory cortical responses to neonatal deafening: pyramidal neuron spine loss without changes in growth or orientation , 2004, Experimental Brain Research.