“Systems of systems” has achieved the vaulted status of a buzzword lately, but is engineering a system of systems any different from engineering a system? This panel has five eminent speakers from the systems engineering world and from the complex systems research world discussing whether or not it really is different, and if it is, how. Certainly systems engineering principles apply, but do they apply differently? Does the emphasis change? How much of the science of complexity theory must an engineer learn, and how much of it is academic and irrelevant? The following arguments will be made and debated, along with some confounding issues such as those listed below.