A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes
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Scott J. Tebbutt | Youngwoong Kim | W. Nicholas Haining | Megan K. Levings | W. Haining | M. Levings | S. Tebbutt | C. Piccirillo | C. Panagiotopoulos | J. Gillies | Constadina Panagiotopoulos | Ciriaco A. Piccirillo | Adele Y. Wang | Amrit Singh | Amrit Singh | Anne M. Pesenacker | Jana Gillies | Duc Nguyen | A. Pesenacker | Duc Nguyen | Youngwoong Kim | Jana K. Gillies | Scott J. Tebbutt | Adele Y. Wang | W. Haining
[1] B. Stranger,et al. Interindividual variation in human T regulatory cells , 2014, Proceedings of the National Academy of Sciences.
[2] Elizabeth Whalen,et al. Multiple Autoimmune-Associated Variants Confer Decreased IL-2R Signaling in CD4+CD25hi T Cells of Type 1 Diabetic and Multiple Sclerosis Patients , 2013, PloS one.
[3] M. Netea,et al. TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment , 2013, The Journal of Immunology.
[4] Raymond T. Ng,et al. A computational pipeline for the development of multi-marker bio-signature panels and ensemble classifiers , 2012, BMC Bioinformatics.
[5] Linda S. Wicker,et al. Type 1 Diabetes-Associated IL2RA Variation Lowers IL-2 Signaling and Contributes to Diminished CD4+CD25+ Regulatory T Cell Function , 2012, The Journal of Immunology.
[6] Mark A. Atkinson,et al. Central Role for Interleukin-2 in Type 1 Diabetes , 2011, Diabetes.
[7] J. Buckner,et al. CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game , 2011, The Journal of Immunology.
[8] Xin Chen,et al. The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4+ FoxP3+ regulatory T cells , 2011, Immunology.
[9] F. Nichols,et al. Natural but Not Inducible Regulatory T Cells Require TNF-α Signaling for In Vivo Function , 2011, The Journal of Immunology.
[10] Jonathan H. Esensten,et al. Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes , 2011, The Journal of Immunology.
[11] Jeff E. Mold,et al. Fetal and Adult Hematopoietic Stem Cells Give Rise to Distinct T Cell Lineages in Humans , 2010, Science.
[12] Q. Ouyang,et al. Cutting Edge: Increased IL-17–Secreting T Cells in Children with New-Onset Type 1 Diabetes , 2010, The Journal of Immunology.
[13] K. Cerosaletti,et al. An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells , 2010, Genes and Immunity.
[14] Jano I van Hemert,et al. Correcting for intra-experiment variation in Illumina BeadChip data is necessary to generate robust gene-expression profiles , 2010, BMC Genomics.
[15] M. Probst-Kepper,et al. FOXP3 and GARP (LRRC32): the master and its minion , 2010, Biology Direct.
[16] C Polychronakos,et al. The type I diabetes association of the IL2RA locus , 2009, Genes and Immunity.
[17] M. Battaglia,et al. The Tregs' world according to GARP , 2009, European journal of immunology.
[18] P. Coulie,et al. Membrane protein GARP is a receptor for latent TGF‐β on the surface of activated human Treg , 2009, European journal of immunology.
[19] K. Cerosaletti,et al. Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects , 2009, Diabetes.
[20] Matthew Hardy,et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource , 2009, Nature Genetics.
[21] Purushottam W. Laud,et al. Apoptosis of CD4+CD25high T Cells in Type 1 Diabetes May Be Partially Mediated by IL-2 Deprivation , 2009, PloS one.
[22] T. Gerds,et al. Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome‐wide gene expression data , 2009, Inflammatory bowel diseases.
[23] T. Nomura,et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. , 2009, Immunity.
[24] E. Sgouroudis,et al. Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease , 2009, Diabetes/metabolism research and reviews.
[25] C. Benoist,et al. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors , 2008, Proceedings of the National Academy of Sciences.
[26] M. Peakman,et al. Increased resistance to CD4+CD25hi regulatory T cell‐mediated suppression in patients with type 1 diabetes , 2008, Clinical and experimental immunology.
[27] W. Friedrich,et al. Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity. , 2008, The Journal of allergy and clinical immunology.
[28] H. Tojo,et al. Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells. , 2008, International immunology.
[29] A. Rudensky,et al. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 , 2007, Nature Immunology.
[30] M. Ramoni,et al. Multiparameter Immune Profiling of Operational Tolerance in Liver Transplantation , 2007, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[31] M. Battaglia,et al. Rapamycin Promotes Expansion of Functional CD4+CD25+FOXP3+ Regulatory T Cells of Both Healthy Subjects and Type 1 Diabetic Patients1 , 2006, The Journal of Immunology.
[32] M. Probst-Kepper,et al. Signatures of human regulatory T cells: an encounter with old friends and new players , 2006, Genome Biology.
[33] J. Mesirov,et al. GenePattern 2.0 , 2006, Nature Genetics.
[34] Jean YH Yang,et al. Bioconductor: open software development for computational biology and bioinformatics , 2004, Genome Biology.
[35] M. Peakman,et al. Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. , 2005, Diabetes.