Treatment of a Case of Fulminant Hepatic Failure with Continuous Infusion of Prostandin (PGE1)

Fulminant hepatic failure is a serious clinical syndrome with high mortality because of the limitation of therapeutic modality. However, survivors usually recover completely. Our experience with prostaglandin E1 (PGE1) treatment of a patient with acute fulminant viral hepatitis, who had a history of blood transfusion and immunosuppressive therapy for aplastic anemia, will be presented.

[1]  S. Seki,et al.  The protective effects of prostaglandin E1 in an experimental massive hepatic cell necrosis model , 1987, Hepatology.

[2]  M. Abecassis,et al.  16, 16 Dimethyl prostaglandin E2 prevents the development of fulminant hepatitis and blocks the induction of monocyte/macrophage procoagulant activity after murine hepatitis virus strain 3 infection. , 1987, The Journal of clinical investigation.

[3]  M. Brunden,et al.  Studies on the mechanism of the protective action of 16,16-dimethylPGE2 in carbon tetrachloride induced acute hepatic injury in the rat. , 1986, Prostaglandins.

[4]  F. Klion,et al.  Massive hepatic necrosis after chemotherapy withdrawal in a hepatitis B virus carrier. , 1985, Archives of internal medicine.

[5]  J. Stachura,et al.  Prostaglandin protection of carbon tetrachloride-induced liver cell necrosis in the rat. , 1981, Gastroenterology.

[6]  L. Ranek,et al.  Fulminant hepatic failure. , 1981, Clinics in gastroenterology.

[7]  B. Rush,et al.  Protective effects of 16,16-dimethyl PGE2 on the liver and kidney. , 1981, Prostaglandins.

[8]  N. Williams,et al.  Limitation of macrophage production in long‐term marrow cultures containing prostaglandin E , 1980, Journal of cellular physiology.

[9]  J. Flynn.  Influence of the arachidonic acid cascade on the in vitro hepatic response to hypoxia. , 1979, Prostaglandins.

[10]  M. Cohen.  MUCOSAL CYTOPROTECTION BY PROSTAGLANDIN E2 , 1978, The Lancet.

[11]  H. Broxmeyer,et al.  Role for monocyte-macrophage-derived colony-stimulating factor and prostaglandin E in the positive and negative feedback control of myeloid stem cell proliferation. , 1978, Blood.

[12]  H. Broxmeyer,et al.  Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E. , 1978, Science.

[13]  J. Motin,et al.  Hepatitis B antigen (HBSAg) and/or antibodies (anti-HBS and anti-HBC) in fulminant hepatitis: pathogenic and prognostic significance. , 1976, Gut.