Ephx2-gene deletion affects acetylcholine-induced relaxation in angiotensin-II infused mice: role of nitric oxide and CYP-epoxygenases

[1]  R. Joannidés,et al.  Endothelium-dependent adaptation of arterial wall viscosity during blood flow increase is impaired in essential hypertension. , 2019, Atherosclerosis.

[2]  Samantha L. Hoopes,et al.  Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia , 2018, The Journal of Biological Chemistry.

[3]  C. Ledent,et al.  Reduced coronary reactive hyperemia in mice was reversed by the soluble epoxide hydrolase inhibitor (t-AUCB): Role of adenosine A2A receptor and plasma oxylipins. , 2017, Prostaglandins & other lipid mediators.

[4]  J. Falck,et al.  Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice , 2017, PloS one.

[5]  J. Falck,et al.  Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases , 2017, PloS one.

[6]  D. Zeldin,et al.  Vascular endothelial over-expression of soluble epoxide hydrolase (Tie2-sEH) enhances adenosine A1 receptor-dependent contraction in mouse mesenteric arteries: role of ATP-sensitive K+ channels , 2016, Molecular and Cellular Biochemistry.

[7]  D. Zeldin,et al.  Effect of Soluble Epoxide Hydrolase on the Modulation of Coronary Reactive Hyperemia: Role of Oxylipins and PPARγ , 2016, PloS one.

[8]  D. Zeldin,et al.  Deletion of soluble epoxide hydrolase enhances coronary reactive hyperemia in isolated mouse heart: role of oxylipins and PPARγ. , 2016, American journal of physiology. Regulatory, integrative and comparative physiology.

[9]  S. Tilley,et al.  Angiotensin II stimulation alters vasomotor response to adenosine in mouse mesenteric artery: role for A1 and A2B adenosine receptors , 2015, British journal of pharmacology.

[10]  C. Ledent,et al.  High salt diet modulates vascular response in A2AAR+/+ and A2AAR−/− mice: role of sEH, PPARγ, and KATP channels , 2015, Molecular and Cellular Biochemistry.

[11]  C. Ledent,et al.  High Salt Diet Exacerbates Vascular Contraction in the Absence of Adenosine A2A Receptor , 2014, Journal of cardiovascular pharmacology.

[12]  M. Nayeem,et al.  Adenosine A1 Receptors Link to Smooth Muscle Contraction Via CYP4a, protein kinase C-&agr;, and ERK1/2 , 2013, Journal of cardiovascular pharmacology.

[13]  B. Hammock,et al.  Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health. , 2013, Annual review of pharmacology and toxicology.

[14]  C. Ledent,et al.  CYP-epoxygenases contribute to A2A receptor-mediated aortic relaxation via sarcolemmal KATP channels. , 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

[15]  J. Falck,et al.  EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides[S] , 2012, Journal of Lipid Research.

[16]  M. Mozaffari,et al.  Tyrosine kinase inhibitor, genistein, reduces renal inflammation and injury in streptozotocin-induced diabetic mice. , 2011, Vascular pharmacology.

[17]  K. Cianflone,et al.  Association between polymorphisms of CYP2J2 and EPHX2 genes and risk of coronary artery disease , 2011, Pharmacogenetics and genomics.

[18]  S. Hwang,et al.  Inhibition of soluble epoxide hydrolase improves the impaired pressure–natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats , 2011, Journal of hypertension.

[19]  V. Richard,et al.  Soluble epoxide hydrolase inhibition prevents coronary endothelial dysfunction in mice with renovascular hypertension , 2011, Journal of hypertension.

[20]  John D Imig,et al.  Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin‐induced type 1 diabetes , 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

[21]  J. Falck,et al.  Salt modulates vascular response through adenosine A2A receptor in eNOS-null mice: role of CYP450 epoxygenase and soluble epoxide hydrolase , 2011, Molecular and Cellular Biochemistry.

[22]  Chen Biao,et al.  Haplotype analysis of the CYP2J2 gene associated with myocardial infarction in a Chinese Han population , 2010, Cell biochemistry and function.

[23]  J. Falck,et al.  Modulation by salt intake of the vascular response mediated through adenosine A(2A) receptor: role of CYP epoxygenase and soluble epoxide hydrolase. , 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

[24]  A. El-Kadi,et al.  Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases. , 2010, Pharmacology & therapeutics.

[25]  S. Shin,et al.  Genetic variation in the G-50T polymorphism of the cytochrome P450 epoxygenase CYP2J2 gene and the risk of younger onset type 2 diabetes among Chinese population: potential interaction with body mass index and family history. , 2010, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[26]  M. Montagnana,et al.  The common functional polymorphism -50G>T of the CYP2J2 gene is not associated with ischemic coronary and cerebrovascular events in an urban-based sample of Swedes , 2010, Journal of hypertension.

[27]  R. Füth,et al.  Variation in the human soluble epoxide hydrolase gene and risk of restenosis after percutaneous coronary intervention , 2009, BMC cardiovascular disorders.

[28]  J. Falck,et al.  Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism , 2009, Neuroscience.

[29]  J. Falck,et al.  High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases. , 2009, American journal of physiology. Regulatory, integrative and comparative physiology.

[30]  H. Hercule,et al.  Interaction Between P450 Eicosanoids and Nitric Oxide in the Control of Arterial Tone in Mice , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[31]  Yunyu Zhang,et al.  Validation of volume-pressure recording tail-cuff blood pressure measurements. , 2008, American journal of hypertension.

[32]  C. Ledent,et al.  Role of CYP epoxygenases in A2A AR-mediated relaxation using A2A AR-null and wild-type mice. , 2008, American journal of physiology. Heart and circulatory physiology.

[33]  C. Langefeld,et al.  Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study , 2008, Diabetes & vascular disease research.

[34]  Martin Vingron,et al.  Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease , 2008, Nature Genetics.

[35]  Craig R. Lee,et al.  Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk. , 2007, Pharmacogenomics.

[36]  Yi Fu,et al.  Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo , 2007, Proceedings of the National Academy of Sciences.

[37]  D. Couper,et al.  CYP2J2 and CYP2C8 polymorphisms and coronary heart disease risk: the Atherosclerosis Risk in Communities (ARIC) study , 2007, Pharmacogenetics and genomics.

[38]  M. Fornage,et al.  Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. , 2006, Human molecular genetics.

[39]  B. Hammock,et al.  Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. , 2005, Annual review of pharmacology and toxicology.

[40]  R. Paules,et al.  Differential renal gene expression in prehypertensive and hypertensive spontaneously hypertensive rats. , 2005, American journal of physiology. Renal physiology.

[41]  B. Hammock,et al.  Soluble epoxide hydrolase is a therapeutic target for acute inflammation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[42]  R. Busse,et al.  Soluble Epoxide Hydrolase Is a Main Effector of Angiotensin II–Induced Hypertension , 2005, Hypertension.

[43]  M. Nayeem Sublethal simulated ischemia promotes delayed resistance against ischemia via ATP-sensitive (K+) channels in murine myocytes: role of PKC and iNOS. , 2004, Antioxidants & redox signaling.

[44]  D. Kroetz,et al.  Vascular localization of soluble epoxide hydrolase in the human kidney. , 2004, American journal of physiology. Renal physiology.

[45]  R. Roman,et al.  Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension , 2004, Current opinion in nephrology and hypertension.

[46]  D. Zeldin,et al.  Up-Regulation of Endothelial Nitric-Oxide Synthase by Endothelium-Derived Hyperpolarizing Factor Involves Mitogen-Activated Protein Kinase and Protein Kinase C Signaling Pathways , 2003, Journal of Pharmacology and Experimental Therapeutics.

[47]  R. Busse,et al.  EDHF: bringing the concepts together. , 2002, Trends in pharmacological sciences.

[48]  M. Nayeem,et al.  Protein kinase C isoforms and A1 adenosine receptors in porcine coronary smooth muscle cells. , 2002, Vascular pharmacology.

[49]  J. Falck,et al.  14,15-Epoxyeicosa-5(Z)-enoic Acid: A Selective Epoxyeicosatrienoic Acid Antagonist That Inhibits Endothelium-Dependent Hyperpolarization and Relaxation in Coronary Arteries , 2002, Circulation research.

[50]  D. Schwartz,et al.  Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. , 2001, American journal of respiratory cell and molecular biology.

[51]  J. Falck,et al.  Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells. , 2001, Molecular pharmacology.

[52]  D. Thompson,et al.  Pathways of Epoxyeicosatrienoic Acid Metabolism in Endothelial Cells , 2001, The Journal of Biological Chemistry.

[53]  F. Gonzalez,et al.  Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation* , 2000, The Journal of Biological Chemistry.

[54]  B D Hammock,et al.  Soluble Epoxide Hydrolase Regulates Hydrolysis of Vasoactive Epoxyeicosatrienoic Acids , 2000, Circulation research.

[55]  Zeldin,et al.  Reply: cytochrome P450-derived eicosanoids and the vascular wall. , 2000, Trends in pharmacological sciences.

[56]  J. Falck,et al.  Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase. , 2000, Journal of lipid research.

[57]  R. Busse,et al.  Cytochrome P450 2C is an EDHF synthase in coronary arteries , 1999, Nature.

[58]  K. Ley,et al.  Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. , 1999, Science.

[59]  N. Weintraub,et al.  Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. , 1998, Circulation research.

[60]  A. Takeshita,et al.  Importance of endothelium-derived hyperpolarizing factor in human arteries. , 1997, The Journal of clinical investigation.

[61]  M. Hess,et al.  Delayed preconditioning of cultured adult rat cardiac myocytes: role of 70- and 90-kDa heat stress proteins. , 1997, The American journal of physiology.

[62]  M. Nayeem,et al.  Monophosphoryl lipid A protects adult rat cardiac myocytes with induction of the 72-kD heat shock protein: a cellular model of pharmacologic preconditioning. , 1997, Journal of molecular and cellular cardiology.

[63]  P. Pratt,et al.  Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. , 1996, Circulation research.

[64]  M. Rosolowsky,et al.  Synthesis of hydroxyeicosatetraenoic (HETEs) and epoxyeicosatrienoic acids (EETs) by cultured bovine coronary artery endothelial cells. , 1996, Biochimica et biophysica acta.

[65]  F. Guengerich,et al.  Purification of human liver cytosolic epoxide hydrolase and comparison to the microsomal enzyme. , 1982, Biochemistry.

[66]  P. Mulder,et al.  Cardiovascular Consequences of Obesity and Type 2 Diabetes Soluble epoxide hydrolase inhibition improves coronary endothelial function and prevents the development of cardiac alterations in obese insulin-resistant mice , 2015 .

[67]  J. Falck,et al.  Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ. , 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

[68]  C. Ledent,et al.  Role of (cid:1) -hydroxylase in adenosine-mediated aortic response through MAP kinase using A 2A -receptor knockout mice , 2012 .

[69]  B. Hammock,et al.  Epoxide hydrolases: their roles and interactions with lipid metabolism. , 2005, Progress in lipid research.

[70]  Xiang Fang,et al.  Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. , 2004, Progress in lipid research.