The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth.
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[1] A. Klippel,et al. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways , 1996, Molecular and cellular biology.
[2] E. Hafen,et al. DOS, a Novel Pleckstrin Homology Domain–Containing Protein Required for Signal Transduction between Sevenless and Ras1 in Drosophila , 1996, Cell.
[3] L. Williams,et al. Cpk Is a Novel Class of Drosophila PtdIns 3-Kinase Containing a C2 Domain* , 1996, The Journal of Biological Chemistry.
[4] M. Czech,et al. Mouse p170 Is a Novel Phosphatidylinositol 3-Kinase Containing a C2 Domain* , 1996, The Journal of Biological Chemistry.
[5] J. Downward,et al. Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation. , 1996, The EMBO journal.
[6] R. Garofalo,et al. The Drosophila insulin receptor is required for normal growth. , 1996, Endocrinology.
[7] M. Zvelebil,et al. Structural and functional diversity of phosphoinositide 3-kinases. , 1996, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[8] M. Waterfield,et al. The study of phosphoinositide 3-kinase function. , 1996, Cancer surveys.
[9] M. Waterfield,et al. A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction , 1995, Current Biology.
[10] K. Zhou,et al. A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development , 1995, Molecular and cellular biology.
[11] B. Burgering,et al. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction , 1995, Nature.
[12] M. Zvelebil,et al. A human phosphatidylinositol 3‐kinase complex related to the yeast Vps34p‐Vps15p protein sorting system. , 1995, The EMBO journal.
[13] M. Frasch,et al. The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential. , 1995, The EMBO journal.
[14] Andrius Kazlauskas,et al. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase , 1995, Cell.
[15] P. Hawkins,et al. PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase , 1995, Current Biology.
[16] G. Cooper,et al. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. , 1995, Science.
[17] Tony Pawson,et al. Protein modules and signalling networks , 1995, Nature.
[18] A. Toker,et al. Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3. , 1994, The Journal of biological chemistry.
[19] C. Kahn,et al. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene , 1994, Nature.
[20] I. Guerrero,et al. Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings. , 1994, The EMBO journal.
[21] Peter J. Parker,et al. The activation of phosphatidylinositol 3-kinase by Ras , 1994, Current Biology.
[22] Michael J. Fry,et al. Phosphatidylinositol-3-OH kinase direct target of Ras , 1994, Nature.
[23] G. Thomas,et al. p70s6k/p85s6k: mechanism of activation and role in mitogenesis. , 1994, Seminars in cancer biology.
[24] K. Staehling-Hampton,et al. Ectopic decapentaplegic in the Drosophila midgut alters the expression of five homeotic genes, dpp, and wingless, causing specific morphological defects. , 1994, Developmental biology.
[25] S. Higashijima,et al. Drosophila phospholipase C-gamma expressed predominantly in blastoderm cells at cellularization and in endodermal cells during later embryonic stages. , 1994, Journal of Biological Chemistry.
[26] Gerald M. Rubin,et al. The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway , 1994, Cell.
[27] Andrius Kazlauskas,et al. PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase , 1994, Nature.
[28] J. Blenis,et al. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation , 1994, Molecular and cellular biology.
[29] Sally J. Leevers,et al. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane , 1994, Nature.
[30] M. Kasuga,et al. Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling , 1994, Current Biology.
[31] I Gout,et al. PI 3‐kinase is a dual specificity enzyme: autoregulation by an intrinsic protein‐serine kinase activity. , 1994, The EMBO journal.
[32] M. Kasuga,et al. PI 3‐kinase: structural and functional analysis of intersubunit interactions. , 1994, The EMBO journal.
[33] E. Wieschaus,et al. wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. , 1994, Development.
[34] P. Hawkins,et al. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. , 1994, Cell.
[35] P. Hawkins,et al. Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? , 1993, Biochimica et biophysica acta.
[36] N. Perrimon,et al. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. , 1993, Development.
[37] A. Kazlauskas,et al. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal , 1993, Cell.
[38] K. Takegawa,et al. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. , 1993, Science.
[39] J. Exton,et al. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. , 1993, The Journal of biological chemistry.
[40] G. Panayotou,et al. Purification and characterization of a phosphatidylinositol 3-kinase complex from bovine brain by using phosphopeptide affinity columns. , 1992, The Biochemical journal.
[41] D. Lindsley,et al. The Genome of Drosophila Melanogaster , 1992 .
[42] K. White,et al. Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. , 1991, Journal of neurobiology.
[43] G. Panayotou,et al. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase , 1991, Cell.
[44] E. Hafen,et al. Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye , 1991, Cell.
[45] R. Schuh,et al. Pattern formation in Drosophila. , 1989, Seminars in cell biology.
[46] L. Cantley,et al. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrates for phospholipases C from rat liver and bovine brain. , 1989, The Journal of biological chemistry.
[47] A. T. Young,et al. Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. , 1989, The Journal of biological chemistry.
[48] D. Branton,et al. Drosophila spectrin. II. Conserved features of the alpha-subunit are revealed by analysis of cDNA clones and fusion proteins , 1987, The Journal of cell biology.
[49] G K Lewis,et al. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product , 1985, Molecular and cellular biology.
[50] M. Rosbash,et al. A Drosophila Minute gene encodes a ribosomal protein , 1985, Nature.
[51] L. Cantley,et al. Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation , 1985, Nature.
[52] J. C. Li,et al. Development in DROSOPHILA MELANOGASTER. , 1927, Genetics.