Food analysis on microchip electrophoresis: An updated review

From 2008 to date, basically, single‐cross microchip electrophoresis (ME) design has been used for food analysis with electrochemicaland laser‐induced fluorescencedetection being the most commonprinciples coupled. In the last 4 years, the main outlines were: (i) the exploration of new analytes such as heavy metals, nitrite, micotoxins, microorganisms, and allergens; (ii) the development of electrokinetic microfluidic (bio‐) sensors into microchip format for the detection of toxins; and interestingly (iii) although sample preparation is still performed off‐chip, an important increase in works dealing with complicated food samples has been clearly noticed. Although microchip technology based on electrokinetics is emerging from important fields such as authentication of foods, detection of frauds, toxics, and allergens; the marriage between micro‐ and nanotechnologies and total integration approaches has not reached the expected impact in the field but it is still a great promise for the development of ME of new generations for food analysis.

[1]  H. T. Im,et al.  Real-time detection of food-borne bacterial adenosine triphosphate (ATP) using dielectrophoretic force and a bioluminescence sensor , 2010 .

[2]  Martin Pumera,et al.  Towards lab-on-a-chip approaches in real analytical domains based on microfluidic chips/electrochemical multi-walled carbon nanotube platforms. , 2009, Lab on a chip.

[3]  Angel Ríos,et al.  Challenges of analytical microsystems , 2006 .

[4]  S. Kang,et al.  Microchip capillary gel electrophoresis using programmed field strength gradients for the ultra-fast analysis of genetically modified organisms in soybeans. , 2005, Journal of chromatography. A.

[5]  Martin Pumera,et al.  Food analysis on microfluidic devices using ultrasensitive carbon nanotubes detectors. , 2007, Analytical chemistry.

[6]  Saverio Mannino,et al.  Microchip capillary electrophoresis with amperometric detection for rapid separation and detection of phenolic acids. , 2004, Journal of chromatography. A.

[7]  Alberto Escarpa,et al.  CE microchips: An opened gate to food analysis , 2007, Electrophoresis.

[8]  W. Hoffmann,et al.  Polymer Lab-on-a-Chip System With Electrical Detection , 2008, IEEE Sensors Journal.

[9]  Bart Nicolai,et al.  Microfluidic analytical systems for food analysis , 2011 .

[10]  S. Kang,et al.  Ultra‐fast simultaneous analysis of genetically modified organisms in maize by microchip electrophoresis with LIF detector , 2007, Electrophoresis.

[11]  Alberto Escarpa,et al.  Real sample analysis on microfluidic devices. , 2007, Talanta.

[12]  Guonan Chen,et al.  Separation and determination of β-casomorphins by using glass microfluidic chip electrophoresis together with laser-induced fluorescence detection. , 2011, Journal of separation science.

[13]  N. Kaji,et al.  Highly sensitive double‐fluorescent dye staining on microchip electrophoresis for analysis of milk proteins , 2008, Electrophoresis.

[14]  Alberto Escarpa,et al.  Microchips for CE: Breakthroughs in real‐world food analysis , 2008, Electrophoresis.

[15]  S. Ohla,et al.  Chip electrophoresis of active banana ingredients with label-free detection utilizing deep UV native fluorescence and mass spectrometry , 2011, Analytical and bioanalytical chemistry.

[16]  Martin Pumera,et al.  Nanomaterials as electrochemical detectors in microfluidics and CE: Fundamentals, designs, and applications , 2009, Electrophoresis.

[17]  Alberto Escarpa,et al.  Fast and simultaneous detection of prominent natural antioxidants using analytical microsystems for capillary electrophoresis with a glassy carbon electrode: A new gateway to food environments , 2005, Electrophoresis.

[18]  M. Pumera,et al.  The preferential electrocatalytic behaviour of graphite and multiwalled carbon nanotubes on enediol groups and their analytical implications in real domains. , 2009, The Analyst.

[19]  Alberto Escarpa,et al.  Integrated electrokinetic magnetic bead-based electrochemical immunoassay on microfluidic chips for reliable control of permitted levels of zearalenone in infant foods. , 2011, The Analyst.

[20]  S. Eo,et al.  Fast microchip electrophoresis using field strength gradients for single nucleotide polymorphism identification of cattle breeds , 2010 .

[21]  P. Verboven,et al.  Modeling and optimization of a multi-enzyme electrokinetically driven multiplexed microchip for simultaneous detection of sugars , 2009 .

[22]  Angel Ríos,et al.  Fast single run of vanilla fingerprint markers on microfluidic‐electrochemistry chip for confirmation of common frauds , 2009, Electrophoresis.

[23]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[24]  Alberto Escarpa,et al.  A fast and reliable route integrating calibration and analysis protocols for water‐soluble vitamin determination on microchip‐electrochemistry platforms , 2006, Electrophoresis.

[25]  A. Manz,et al.  Miniaturized total chemical analysis systems: A novel concept for chemical sensing , 1990 .

[26]  Alberto Escarpa,et al.  Electrochemical microfluidic chips coupled to magnetic bead-based ELISA to control allowable levels of zearalenone in baby foods using simplified calibration. , 2009, The Analyst.

[27]  A modified electrode for the electrochemical detection of biogenic amines and their amino acid precursors separated by microchip capillary electrophoresis , 2011, Electrophoresis.

[28]  M. Neville,et al.  Determination of total protein in human milk: comparison of methods. , 1986, Clinical chemistry.

[29]  Alberto Escarpa,et al.  Electrochemical immunosensing on board microfluidic chip platforms , 2012 .

[30]  C. Garino,et al.  Microchip capillary electrophoresis (Lab-on-chip®) improves detection of celery (Apium graveolens L.) and sesame (Sesamum indicum L.) in foods , 2010 .

[31]  S. Kang,et al.  Separation of DNA fragments for fast diagnosis by microchip electrophoresis using programmed field strength gradient , 2005, Electrophoresis.

[32]  A. Escarpa,et al.  Electrochemical detection in capillary electrophoresis on microchips , 2005 .

[33]  Jun-bo Zhang,et al.  A novel miniaturised electrophoretic method for determining formaldehyde and acetaldehyde in food using 2-thiobarbituric acid derivatisation , 2011 .

[34]  Andreas Manz,et al.  Scaling and the design of miniaturized chemical-analysis systems , 2006, Nature.

[35]  Y. Shim,et al.  Simultaneous analysis of nitrate and nitrite in a microfluidic device with a Cu‐complex‐modified electrode , 2006, Electrophoresis.

[36]  Y. Shim,et al.  Development of extraction and analytical methods of nitrite ion from food samples: microchip electrophoresis with a modified electrode. , 2009, Journal of agricultural and food chemistry.

[37]  Xuan Weng,et al.  Rapid detection of formaldehyde concentration in food on a polydimethylsiloxane (PDMS) microfluidic chip , 2009 .

[38]  T. García,et al.  Application of polymerase chain reaction–restriction fragment length polymorphism analysis and lab-on-a-chip capillary electrophoresis for the specific identification of game and domestic meats , 2009 .

[39]  S. Kang,et al.  Microchip gel electrophoresis with programmed field strength gradients for ultra-fast detection of canine T-cell lymphoma in dogs. , 2008, Talanta.

[40]  Hui-Ling Lee,et al.  Fast Analysis of Phenolic Acids by Microchip Capillary Electrophoresis with Serpentine Channel and End Wrapped Electrode , 2010 .

[41]  Alberto Escarpa,et al.  Fast and selective microfluidic chips for electrochemical antioxidant sensing in complex samples. , 2010, Analytical chemistry.

[42]  Orawon Chailapakul,et al.  Fast and simultaneous detection of heavy metals using a simple and reliable microchip-electrochemistry route: An alternative approach to food analysis. , 2008, Talanta.