Antisulfatide antibody and neuropathy in a patient with Gaucher's disease

We report the presence of antisulfatide antibodies in a patient with type I Gaucher's disease and peripheral neuropathy.The association of Gaucher's disease with hypergammaglobulinemia and monoclonal gammopathy is well documented whereas its association with peripheral neuropathy is rare. We discuss whether antibodies directed against the sulfatide antigen are related to Gaucher's disease or are a coincidental association. NEUROLOGY 1995;45: 1622-1623

[1]  A. Harding,et al.  Coexistence of hereditary motor and sensory neuropathy type IA and IGM paraproteinemic neuropathy , 1993, Annals of neurology.

[2]  A. Lugaresi,et al.  Anti-sulfatide antibodies in neurological disease: binding to rat dorsal root ganglia neurons , 1992, Journal of the Neurological Sciences.

[3]  H. Vinters.  Cerebral amyloid angiopathy and alzheimer's disease: two entities or one? , 1992, Journal of Neurological Sciences.

[4]  Upadhyay Rb.  Factors associated with fertility change in India (1971 to 1985): a path-analysis model. , 1988 .

[5]  S. Dikman,et al.  Amyloidosis. An unusual complication of Gaucher's disease. , 1978, Archives of pathology & laboratory medicine.

[6]  L. Yam,et al.  Gaucher's disease associated with chronic lymphocytic leukaemia, gout and carcinoma , 1975, The Journal of pathology.

[7]  S. Kochwa,et al.  Immunoglobulin abnormalities in Gaucher's disease. Report of 16 cases. , 1968, Blood.

[8]  M. Yaron,et al.  Coincidence of multiple myeloma with Gaucher's disease. , 1965, Israel journal of medical sciences.

[9]  G. Grabowski.  Gaucher disease. Enzymology, genetics, and treatment. , 1993, Advances in human genetics.

[10]  J. Pinkhas,et al.  Peripheral cryoglobulinemic neuropathy in a patient with Gaucher's disease. , 1978, Acta Haematologica.

[11]  H. Lehmann,et al.  Interaction between Iron Deficiency and α-Thalassaemia: the in vitro Effect of Haemin on α-Chain Synthesis , 1978 .

[12]  A. Goldfarb,et al.  Electrophoretic studies in Gaucher's disease. , 1950, American journal of clinical pathology.