Small Molecule Kinase Inhibitors Provide Insight into Mps1 Cell Cycle Function
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Taebo Sim | Stefan Knapp | Panagis Filippakopoulos | Jagesh V. Shah | Meera Soundararajan | Nathanael S. Gray | David Pellman | S. Knapp | N. Gray | H. Choi | Michael S. Manak | J. Shah | Q. Deveraux | D. Pellman | G. Kops | P. Filippakopoulos | Nicholas Kwiatkowski | T. Sim | M. Kwon | Nicholas Kwiatkowski | Quinn L. Deveraux | Hwan Geun Choi | Mijung Kwon | Nannette Jelluma | Sabine Rottmann | Geert J.P.L. Kops | S. Rottmann | M. Soundararajan | N. Jelluma | Taebo Sim | Meera Soundararajan
[1] R. Medema,et al. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells , 2009, Proceedings of the National Academy of Sciences.
[2] M. Winey,et al. New alleles of the yeast MPS1 gene reveal multiple requirements in spindle pole body duplication. , 1998, Molecular biology of the cell.
[3] M. Winey,et al. Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[4] E. Dı́az-Rodrı́guez,et al. Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[5] Chao Zhang,et al. Chemical Genetics Reveals a Role for Mps1 Kinase in Kinetochore Attachment during Mitosis , 2005, Current Biology.
[6] D. Cleveland,et al. Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis , 2009, Nature Reviews Molecular Cell Biology.
[7] K. Resing,et al. Mps1 Activation Loop Autophosphorylation Enhances Kinase Activity* , 2007, Journal of Biological Chemistry.
[8] C. Harley,et al. Extension of life-span by introduction of telomerase into normal human cells. , 1998, Science.
[9] E. Nigg,et al. Plk4-induced centriole biogenesis in human cells. , 2007, Developmental cell.
[10] Geert J P L Kops,et al. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[11] Lionel Arnaud,et al. Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication , 2002, The EMBO journal.
[12] Stephen S. Taylor,et al. Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores , 2008, The Journal of cell biology.
[13] P. Sorger,et al. Generating chromosome instability through the simultaneous deletion of Mad2 and p53. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[14] Elliot Botvinick,et al. Dynamics of Centromere and Kinetochore Proteins Implications for Checkpoint Signaling and Silencing , 2004, Current Biology.
[15] M. Winey,et al. The Mouse Mps1p-like Kinase Regulates Centrosome Duplication , 2001, Cell.
[16] Alexey Khodjakov,et al. Centrosome Amplification Can Initiate Tumorigenesis in Flies , 2008, Cell.
[17] H. Saya,et al. Autophosphorylation of a Newly Identified Site of Aurora-B Is Indispensable for Cytokinesis* , 2004, Journal of Biological Chemistry.
[18] N. Ahn,et al. Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation. , 2009, Molecular biology of the cell.
[19] M. Winey,et al. Preventing the degradation of mps1 at centrosomes is sufficient to cause centrosome reduplication in human cells. , 2007, Molecular biology of the cell.
[20] Leonard M. G. Chavas,et al. Crystal Structure of the Catalytic Domain of the Mitotic Checkpoint Kinase Mps1 in Complex with SP600125* , 2008, Journal of Biological Chemistry.
[21] A. Bernards,et al. The ltk receptor tyrosine kinase is expressed in pre‐B lymphocytes and cerebral neurons and uses a non‐AUG translational initiator. , 1990, The EMBO journal.
[22] Eric L. Weiss,et al. Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase. , 1995, The EMBO journal.
[23] W. Gerald,et al. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells , 2001, Nature.
[24] E. Nigg,et al. Role of Hec1 in Spindle Checkpoint Signaling and Kinetochore Recruitment of Mad1/Mad2 , 2002, Science.
[25] A. Iafrate,et al. Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling , 2007, Proceedings of the National Academy of Sciences.
[26] L. Wodicka,et al. A small molecule–kinase interaction map for clinical kinase inhibitors , 2005, Nature Biotechnology.
[27] David Bebbington,et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo , 2004, Nature Medicine.
[28] Marc Schmidt,et al. Ablation of the spindle assembly checkpoint by a compound targeting Mps1 , 2005, EMBO reports.
[29] E. Salmon,et al. The spindle-assembly checkpoint in space and time , 2007, Nature Reviews Molecular Cell Biology.
[30] K. Resing,et al. Structural and mechanistic insights into Mps1 kinase activation , 2009, Journal of cellular and molecular medicine.
[31] E. Salmon,et al. Spindle Checkpoint Protein Dynamics at Kinetochores in Living Cells , 2004, Current Biology.
[32] Song-Tao Liu,et al. Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores. , 2003, Molecular biology of the cell.
[33] J. Labbé,et al. Kinetochore localization of spindle checkpoint proteins: who controls whom? , 2004, Molecular biology of the cell.
[34] J. Yates,et al. Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes , 2008, PloS one.
[35] D. Pellman,et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. , 2008, Genes & development.
[36] L. Tabernero,et al. Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes. , 2010, Biochemistry.
[37] Alexey Khodjakov,et al. Extra centrosomes and/or chromosomes prolong mitosis in human cells , 2008, Nature Cell Biology.
[38] Mindy I. Davis,et al. A quantitative analysis of kinase inhibitor selectivity , 2008, Nature Biotechnology.
[39] E. Nigg,et al. Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1 , 2004, Chromosoma.
[40] M. Winey,et al. MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication , 1991, The Journal of cell biology.
[41] T. Arakawa,et al. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system , 1997, Oncogene.
[42] Bert Vogelstein,et al. Mutations of mitotic checkpoint genes in human cancers , 1998, Nature.
[43] Mathias Schmidt,et al. Mitotic drug targets and the development of novel anti-mitotic anticancer drugs. , 2007, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[44] Andrew W. Murray,et al. A Small-Molecule Inhibitor of Mps1 Blocks the Spindle-Checkpoint Response to a Lack of Tension on Mitotic Chromosomes , 2005, Current Biology.
[45] R. Mahmood,et al. Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency , 2004, Cancer Research.
[46] Péter Lénárt,et al. BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo , 2007, Current Biology.
[47] R. Medema,et al. Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment , 2008, Cell.
[48] J. Labbé,et al. Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint , 2001, Cell.
[49] Peter G. Schultz,et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK , 2007, Proceedings of the National Academy of Sciences.