Fluorescent nanoparticles based on AIE fluorogens for bioimaging.

Fluorescent nanoparticles (FNPs) have recently attracted increasing attention in the biomedical field because of their unique optical properties, easy fabrication and outstanding performance in imaging. Compared with conventional molecular probes including small organic dyes and fluorescent proteins, FNPs based on aggregation-induced emission (AIE) fluorogens have shown significant advantages in tunable emission and brightness, good biocompatibility, superb photo- and physical stability, potential biodegradability and facile surface functionalization. In this review, we summarize the latest advances in the development of fluorescent nanoparticles based on AIE fluorogens including polymer nanoparticles and silica nanoparticles over the past few years, and the various biomedical applications based on these fluorescent nanoparticles are also elaborated.

[1]  Jin Ouyang,et al.  Dual-emission fluorescent sensor based on AIE organic nanoparticles and Au nanoclusters for the detection of mercury and melamine. , 2015, Nanoscale.

[2]  Changfeng Wu,et al.  Highly efficient near-infrared organic dots based on novel AEE fluorogen for specific cancer cell imaging , 2015 .

[3]  Ben Zhong Tang,et al.  High‐Order Non‐Linear Optical Effects in Organic Luminogens with Aggregation‐Induced Emission , 2015, Advanced materials.

[4]  Yen Wei,et al.  Fluorescent Glycopolymer Nanoparticles Based on Aggregation‐Induced Emission Dyes: Preparation and Bioimaging Applications , 2015 .

[5]  Yen Wei,et al.  A novel fluorescent amphiphilic glycopolymer based on a facile combination of isocyanate and glucosamine , 2015 .

[6]  Lei Tao,et al.  Amphiphilic fluorescent copolymers via one-pot combination of chemoenzymatic transesterification and RAFT polymerization: synthesis, self-assembly and cell imaging , 2015 .

[7]  Kai Li,et al.  Precise and long-term tracking of adipose-derived stem cells and their regenerative capacity via superb bright and stable organic nanodots. , 2014, ACS nano.

[8]  Lei Zhang,et al.  Ultra bright red AIE dots for cytoplasm and nuclear imaging , 2014 .

[9]  Kai Li,et al.  Organic nanoparticles with aggregation-induced emission for tracking bone marrow stromal cells in the rat ischemic stroke model. , 2014, Chemical communications.

[10]  Ben Zhong Tang,et al.  Ultrabright organic dots with aggregation-induced emission characteristics for cell tracking. , 2014, Biomaterials.

[11]  Kai Li,et al.  Polymer-encapsulated organic nanoparticles for fluorescence and photoacoustic imaging. , 2014, Chemical Society reviews.

[12]  Lei Tao,et al.  Aggregation induced emission-based fluorescent nanoparticles: fabrication methodologies and biomedical applications. , 2014, Journal of materials chemistry. B.

[13]  B. Tang,et al.  AIE macromolecules: syntheses, structures and functionalities. , 2014, Chemical Society reviews.

[14]  Yen Wei,et al.  Glycosylated aggregation induced emission dye based fluorescent organic nanoparticles: preparation and bioimaging applications , 2014 .

[15]  Bin Xu,et al.  Folic acid-functionalized AIE Pdots based on amphiphilic PCL-b-PEG for targeted cell imaging , 2014 .

[16]  W. Tian,et al.  Pluronic F127–folic acid encapsulated nanoparticles with aggregation-induced emission characteristics for targeted cellular imaging , 2014 .

[17]  A. Qin,et al.  Red Emissive Biocompatible Nanoparticles from Tetraphenylethene‐Decorated BODIPY Luminogens for Two‐Photon Excited Fluorescence Cellular Imaging and Mouse Brain Blood Vascular Visualization , 2014 .

[18]  Yen Wei,et al.  Facile fabrication of AIE-based stable cross-linked fluorescent organic nanoparticles for cell imaging. , 2014, Colloids and surfaces. B, Biointerfaces.

[19]  Xing-jie Liang,et al.  Imaging intracellular anticancer drug delivery by self-assembly micelles with aggregation-induced emission (AIE micelles). , 2014, ACS applied materials & interfaces.

[20]  Dan Wang,et al.  Biocompatible and Photostable AIE Dots with Red Emission for In Vivo Two-Photon Bioimaging , 2014, Scientific Reports.

[21]  Xu Zhang,et al.  Spatiotemporal Drug Release Visualized through a Drug Delivery System with Tunable Aggregation‐Induced Emission , 2014, Advanced materials.

[22]  Meizhen Yin,et al.  Design and development of fluorescent nanostructures for bioimaging , 2014 .

[23]  Jia-rui Xu,et al.  Preparation of biocompatible aggregation-induced emission homopolymeric nanoparticles for cell imaging. , 2014, Macromolecular bioscience.

[24]  Kai Li,et al.  Bright and Photostable Organic Fluorescent Dots with Aggregation‐Induced Emission Characteristics for Noninvasive Long‐Term Cell Imaging , 2014 .

[25]  B. Liu,et al.  Near-infrared fluorescence amplified organic nanoparticles with aggregation-induced emission characteristics for in vivo imaging. , 2014, Nanoscale.

[26]  V. Biju.  Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy. , 2014, Chemical Society reviews.

[27]  Bai Yang,et al.  Fluorescent aptasensor based on aggregation-induced emission probe and graphene oxide. , 2014, Analytical chemistry.

[28]  Yen Wei,et al.  Novel biocompatible cross-linked fluorescent polymeric nanoparticles based on an AIE monomer , 2014 .

[29]  Chang-Tong Yang,et al.  Gadolinium‐Functionalized Aggregation‐Induced Emission Dots as Dual‐Modality Probes for Cancer Metastasis Study , 2013, Advanced healthcare materials.

[30]  Ben Zhong Tang,et al.  Ultrabright Organic Dots with Aggregation‐Induced Emission Characteristics for Real‐Time Two‐Photon Intravital Vasculature Imaging , 2013, Advanced materials.

[31]  Li-juan Wang,et al.  Multi-stimuli responsive fluorescence switching: the reversible piezochromism and protonation effect of a divinylanthracene derivative , 2013 .

[32]  Ben Zhong Tang,et al.  Organic Dots with Aggregation-Induced Emission (AIE Dots) Characteristics for Dual-Color Cell Tracing , 2013 .

[33]  Lei Tao,et al.  Size tunable fluorescent nano-graphite oxides: preparation and cell imaging applications. , 2013, Physical chemistry chemical physics : PCCP.

[34]  Sean Xiao‐An Zhang,et al.  A TPE-oxazoline molecular switch with tunable multi-emission in both solution and solid state , 2013 .

[35]  Bai Yang,et al.  Self-assembled graphene quantum dots induced by cytochrome c: a novel biosensor for trypsin with remarkable fluorescence enhancement. , 2013, Nanoscale.

[36]  Wei Qin,et al.  Fluorescent AIE dots encapsulated organically modified silica (ORMOSIL) nanoparticles for two-photon cellular imaging , 2013, Science China Chemistry.

[37]  B. Tang,et al.  Probing the pH-dependent chain dynamics of poly(acrylate acid) in concentrated solution by using a cationic AIE fluorophore , 2013, Science China Chemistry.

[38]  Yen Wei,et al.  Facile fabrication and cell imaging applications of aggregation-induced emission dye-based fluorescent organic nanoparticles , 2013 .

[39]  Lei Tao,et al.  PEGylation of fluoridated hydroxyapatite (FAp):Ln3+ nanorods for cell imaging , 2013 .

[40]  Ryan T. K. Kwok,et al.  Long-term fluorescent cellular tracing by the aggregates of AIE bioconjugates. , 2013, Journal of the American Chemical Society.

[41]  B. Tang,et al.  Fabrication of chitosan nanoparticles with aggregation-induced emission characteristics and their applications in long-term live cell imaging. , 2013, Macromolecular rapid communications.

[42]  Lei Tao,et al.  Carbon-dots derived from nanodiamond: photoluminescence tunable nanoparticles for cell imaging. , 2013, Journal of colloid and interface science.

[43]  Li-juan Wang,et al.  Remarkable fluorescence change based on the protonation-deprotonation control in organic crystals. , 2013, Chemical communications.

[44]  Lei Tao,et al.  Facile incorporation of aggregation-induced emission materials into mesoporous silica nanoparticles for intracellular imaging and cancer therapy. , 2013, ACS applied materials & interfaces.

[45]  Lingxin Chen,et al.  SERS tags: novel optical nanoprobes for bioanalysis. , 2013, Chemical reviews.

[46]  Kai Li,et al.  Conjugated Polymer Amplified Far‐Red/Near‐Infrared Fluorescence from Nanoparticles with Aggregation‐Induced Emission Characteristics for Targeted In Vivo Imaging , 2013, Advanced healthcare materials.

[47]  Lei Zhang,et al.  Folic acid-functionalized mesoporous silica nanospheres hybridized with AIE luminogens for targeted cancer cell imaging. , 2013, Nanoscale.

[48]  Kai Li,et al.  Photostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing , 2013, Scientific Reports.

[49]  Lei Tao,et al.  Surfactant modification of aggregation-induced emission material as biocompatible nanoparticles: facile preparation and cell imaging. , 2013, Nanoscale.

[50]  B. Tang,et al.  Biotin-decorated fluorescent silica nanoparticles with aggregation-induced emission characteristics: fabrication, cytotoxicity and biological applications. , 2013, Journal of materials chemistry. B.

[51]  B. Liu,et al.  Lipid-PEG-folate encapsulated nanoparticles with aggregation induced emission characteristics: cellular uptake mechanism and two-photon fluorescence imaging. , 2012, Small.

[52]  Lei Tao,et al.  Fluoridated HAp:Ln3+ (Ln = Eu or Tb) nanoparticles for cell-imaging. , 2012, Nanoscale.

[53]  Lijuan Wang,et al.  Piezochromic luminescence based on the molecular aggregation of 9,10-bis((E)-2-(pyrid-2-yl)vinyl)anthracene. , 2012, Angewandte Chemie.

[54]  D. Ding,et al.  Aggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging , 2012 .

[55]  Ben Zhong Tang,et al.  Specific detection of integrin αvβ3 by light-up bioprobe with aggregation-induced emission characteristics. , 2012, Journal of the American Chemical Society.

[56]  Hoi Sing Kwok,et al.  A tetraphenylethene-based red luminophor for an efficient non-doped electroluminescence device and cellular imaging , 2012 .

[57]  D. Meldrum,et al.  Using fluorine-containing amphiphilic random copolymers to manipulate the quantum yields of aggregation-induced emission fluorophores in aqueous solutions and the use of these polymers for fluorescent bioimaging. , 2012, Journal of materials chemistry.

[58]  Kwangmeyung Kim,et al.  Multifunctional nanoparticles for multimodal imaging and theragnosis. , 2012, Chemical Society reviews.

[59]  Clemens Burda,et al.  The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy. , 2012, Chemical Society reviews.

[60]  Subinoy Rana,et al.  Surface functionalization of nanoparticles for nanomedicine. , 2012, Chemical Society reviews.

[61]  D. Meldrum,et al.  A series of poly[N-(2-hydroxypropyl)methacrylamide] copolymers with anthracene-derived fluorophores showing aggregation-induced emission properties for bioimaging. , 2012, Journal of polymer science. Part A, Polymer chemistry.

[62]  Ben Zhong Tang,et al.  Biocompatible Nanoparticles with Aggregation‐Induced Emission Characteristics as Far‐Red/Near‐Infrared Fluorescent Bioprobes for In Vitro and In Vivo Imaging Applications , 2012 .

[63]  Ben Zhong Tang,et al.  Aggregation-induced emission. , 2011, Chemical Society reviews.

[64]  Erlong Zhang,et al.  A review of NIR dyes in cancer targeting and imaging. , 2011, Biomaterials.

[65]  Sailing He,et al.  Aggregation-enhanced fluorescence in PEGylated phospholipid nanomicelles for in vivo imaging. , 2011, Biomaterials.

[66]  P. Lai,et al.  Sized controlled synthesis, purification, and cell studies with silicon quantum dots. , 2011, Nanoscale.

[67]  Mykhailo V Bondar,et al.  Folate receptor-targeted aggregation-enhanced near-IR emitting silica nanoprobe for one-photon in vivo and two-photon ex vivo fluorescence bioimaging. , 2011, Bioconjugate chemistry.

[68]  B. Liu,et al.  Folic acid-functionalized two-photon absorbing nanoparticles for targeted MCF-7 cancer cell imaging. , 2011, Chemical communications.

[69]  Jiechao Ge,et al.  New sensing mechanisms for design of fluorescent chemosensors emerging in recent years. , 2011, Chemical Society reviews.

[70]  B. Tang,et al.  Covalent immobilization of aggregation-induced emission luminogens in silica nanoparticles through click reaction. , 2011, Small.

[71]  B. Tang,et al.  Fabrication of Silica Nanoparticles with Both Efficient Fluorescence and Strong Magnetization and Exploration of Their Biological Applications , 2011 .

[72]  Yu Qin,et al.  Functional nanoprobes for ultrasensitive detection of biomolecules. , 2010, Chemical Society reviews.

[73]  Kemin Wang,et al.  Ultrasmall near-infrared gold nanoclusters for tumor fluorescence imaging in vivo. , 2010, Nanoscale.

[74]  Sheila N. Baker,et al.  Luminescent carbon nanodots: emergent nanolights. , 2010, Angewandte Chemie.

[75]  T. Duong,et al.  Fluoro- and chromogenic chemodosimeters for heavy metal ion detection in solution and biospecimens. , 2010, Chemical reviews.

[76]  Kazuya Kikuchi,et al.  Design, synthesis and biological application of chemical probes for bio-imaging. , 2010, Chemical Society reviews.

[77]  P. Choyke,et al.  New strategies for fluorescent probe design in medical diagnostic imaging. , 2010, Chemical Reviews.

[78]  A. Jen,et al.  Enhancement of Aggregation‐Induced Emission in Dye‐Encapsulating Polymeric Micelles for Bioimaging , 2010 .

[79]  B. Tang,et al.  Fabrication of fluorescent silica nanoparticles hybridized with AIE luminogens and exploration of their applications as nanobiosensors in intracellular imaging. , 2010, Chemistry.

[80]  A. Demchenko.  The Concept of λ-Ratiometry in Fluorescence Sensing and Imaging , 2010, Journal of Fluorescence.

[81]  Soojin Lim,et al.  NIR dyes for bioimaging applications. , 2010, Current opinion in chemical biology.

[82]  Jiating He,et al.  Novel fluorescent pH sensors and a biological probe based on anthracene derivatives with aggregation-induced emission characteristics. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[83]  Hoi Sing Kwok,et al.  Functionalized Siloles: Versatile Synthesis, Aggregation‐Induced Emission, and Sensory and Device Applications , 2009 .

[84]  Xiaogang Liu,et al.  Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals. , 2009, Chemical Society reviews.

[85]  Vincent M. Rotello,et al.  Applications of Nanoparticles in Biology , 2008 .

[86]  L. Archer,et al.  Hollow Micro‐/Nanostructures: Synthesis and Applications , 2008 .

[87]  A. Mohs,et al.  Bioconjugated quantum dots for in vivo molecular and cellular imaging. , 2008, Advanced drug delivery reviews.

[88]  Wenjun Zhao,et al.  Bioconjugated silica nanoparticles: Development and applications , 2008 .

[89]  Dylan W Domaille,et al.  Synthetic fluorescent sensors for studying the cell biology of metals. , 2008, Nature chemical biology.

[90]  Adela C. Bonoiu,et al.  Aggregation‐Enhanced Fluorescence in Organically Modified Silica Nanoparticles: A Novel Approach toward High‐Signal‐Output Nanoprobes for Two‐Photon Fluorescence Bioimaging , 2007 .

[91]  Kwangmeyung Kim,et al.  Polymers for bioimaging , 2007 .

[92]  Paras N Prasad,et al.  Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. , 2007, Journal of the American Chemical Society.

[93]  J. Wilcoxon,et al.  Synthesis, structure and properties of metal nanoclusters. , 2006, Chemical Society reviews.

[94]  D. Sames,et al.  Selective C-arylation of free (NH)-heteroarenes via catalytic C-H bond functionalization [J. Am. Chem. Soc. 2003, 125, 5274-5275]. , 2006, Journal of the American Chemical Society.

[95]  Robert N Grass,et al.  In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility. , 2006, Environmental science & technology.

[96]  Weihong Tan,et al.  Ultrasensitive DNA detection using highly fluorescent bioconjugated nanoparticles. , 2003, Journal of the American Chemical Society.

[97]  Weihong Tan,et al.  DESIGNING A NOVEL MOLECULAR BEACON FOR SURFACE-IMMOBILIZED DNA HYBRIDIZATION STUDIES , 1999 .

[98]  A. Maitra,et al.  Nanometer Silica Particles Encapsulating Active Compounds: A Novel Ceramic Drug Carrier , 1998 .

[99]  D. Ding,et al.  A fluorescent light-up nanoparticle probe with aggregation-induced emission characteristics and tumor-acidity responsiveness for targeted imaging and selective suppression of cancer cells , 2015 .

[100]  Yen Wei,et al.  A novel method for preparing AIE dye based cross-linked fluorescent polymeric nanoparticles for cell imaging , 2014 .

[101]  Yen Wei,et al.  Polymerizable aggregation-induced emission dye-based fluorescent nanoparticles for cell imaging applications , 2014 .

[102]  Qidai Chen,et al.  Aggregation induced enhanced emission of conjugated dendrimers with a large intrinsic two-photon absorption cross-section , 2014 .

[103]  Yen Wei,et al.  Fabrication of aggregation induced emission dye-based fluorescent organic nanoparticles via emulsion polymerization and their cell imaging applications , 2014 .

[104]  Bin Xu,et al.  Highly sensitive determination of ssDNA and real-time sensing of nuclease activity and inhibition based on the controlled self-assembly of a 9,10-distyrylanthracene probe , 2013, Analytical and Bioanalytical Chemistry.

[105]  Hooisweng Ow,et al.  Bright and stable core-shell fluorescent silica nanoparticles. , 2005, Nano letters.

[106]  H S Kwok,et al.  Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole. , 2001, Chemical communications.