Glucose biosensor of ruthenium-doped TiO2 sensing electrode by co-sputtering system

Abstract In this study, the ruthenium-doped titanium dioxide (TiO 2 :Ru) sensing film is fabricated by co-sputtering system. The TiO 2 :Ru sensing film is treated by thermal annealing process at 600 °C for 1 h in atmosphere. We present a TiO 2 :Ru-based pH sensor which can obtain the higher sensing value at 64.58 mV/pH for the super-Nernstian response. The enzyme composite solution is dropped on the TiO 2 :Ru sensing film as a glucose biosensor. In the concentration ranging from 100 to 500 (mg/dL) of glucose solution, the sensitivity and linearity of TiO 2 :Ru sensing film after thermal annealing are 0.320 mV(mg/dL) −1 and 0.995, respectively, which is better than non-annealing TiO 2 :Ru sensing film. In this study, we can describe a novel doping method to prepare the TiO 2 :Ru sensing film and the glucose biosensors.

[1]  J. Janata,et al.  Field effect transistor sensitive to penicillin , 1980 .

[2]  L. Roué,et al.  XPS surface study of nanocrystalline Ti Ru Fe materials , 2000 .

[3]  Ernö Pretsch,et al.  Lowering the detection limit of solvent polymeric ion-selective electrodes. 1. Modeling the influence of steady-state ion fluxes , 1999 .

[4]  Jung-Chuan Chou,et al.  Fabrication and Application of Ruthenium-Doped Titanium Dioxide Films as Electrode Material for Ion-Sensitive Extended-Gate FETs , 2009, IEEE Sensors Journal.

[5]  B Danielsson,et al.  Selective calcium ion detection with functionalized ZnO nanorods-extended gate MOSFET. , 2009, Biosensors & bioelectronics.

[6]  Reinhard Renneberg,et al.  Encapsulation of glucose oxidase microparticles within a nanoscale layer-by-layer film: immobilization and biosensor applications. , 2003, Biosensors & bioelectronics.

[7]  M. Swaminathan,et al.  Photovalorisation of pentafluorobenzoic acid with platinum doped TiO2. , 2009, Journal of hazardous materials.

[8]  Feng-Chin Wu,et al.  Solute adsorption and enzyme immobilization on chitosan beads prepared from shrimp shell wastes. , 2001, Bioresource technology.

[9]  J. Chou,et al.  Study on pH at the point of zero charge of TiO2 pH ion-sensitive field effect transistor made by the sputtering method , 2005 .

[10]  Xi Chen,et al.  Synthesis and photocatalytic applications of Ag/TiO2-nanotubes. , 2009, Talanta.

[11]  Tai-Ping Sun,et al.  Differential type solid-state urea biosensors based on ion-selective electrodes , 2008 .

[12]  Feng-Chin Wu,et al.  Use of chemically modified chitosan beads for sorption and enzyme immobilization , 2002 .

[13]  Jung-Chuan Chou,et al.  Study on the temperature effects of Al2O3 gate pH-ISFET , 2002 .

[14]  Wensheng Yang,et al.  Direct electrochemistry of glucose oxidase on a graphite nanosheet–Nafion composite film modified electrode , 2009 .

[15]  Tai-Ping Sun,et al.  Development of the tin oxide pH electrode by the sputtering method , 2005 .

[16]  Changqing Sun,et al.  Glucose oxidase/colloidal gold nanoparticles immobilized in Nafion film on glassy carbon electrode: Direct electron transfer and electrocatalysis. , 2006, Bioelectrochemistry.

[17]  S. Reddy,et al.  Entrapment of glucose oxidase in non-porous poly(vinyl chloride) , 2002 .

[18]  P Bergveld,et al.  Development of an ion-sensitive solid-state device for neurophysiological measurements. , 1970, IEEE transactions on bio-medical engineering.

[19]  G. Wei,et al.  Preparation and photocatalytic activity of nanoglued Sn-doped TiO2. , 2009, Journal of hazardous materials.

[20]  Chang-Soo Kim,et al.  ISFET glucose sensor based on a new principle using the electrolysis of hydrogen peroxide , 1997 .

[21]  R. C. King,et al.  Handbook of X Ray Photoelectron Spectroscopy: A Reference Book of Standard Spectra for Identification and Interpretation of Xps Data , 1995 .

[22]  Zhuyi Wang,et al.  Photocatalytic degradation of C.I. Acid Orange 52 in the presence of Zn-doped TiO2 prepared by a stearic acid gel method , 2008 .

[23]  T. Sun,et al.  Effects of Tin Oxide Sputtered on a Carbon Electrode for Fabricating Glucose Biosensor , 2008 .

[24]  J. Chou,et al.  Development of a Disposable All-Solid-State Ascorbic Acid Biosensor and Miniaturized Reference Electrode Fabricated on Single Substrate , 2008, IEEE Sensors Journal.

[25]  J. Chou,et al.  Simulation of Ta2O5-gate ISFET temperature characteristics , 2000 .

[26]  T. Sun,et al.  Integration of Dual-Mode Glucose Biosensor and pH Sensor via a SnO2/Carbon Electrode and Dual-Mode Circuit , 2009 .

[27]  T. Sun,et al.  Preliminary investigations on a glucose biosensor based on the potentiometric principle , 2007 .