Lichen Sclerosus of the Male Genitalia and Urethral Stricture Diseases

Introduction: The true incidence of urethral involvement in patients with genital lichen sclerosus (LS) is unknown. We review the epidemiology and discuss the pathogenesis of LS and urethral stricture diseases. Materials and Methods: During the period 1991–2002, of 925 patients who underwent urethroplasty for anterior urethral stricture, 130 patients (14%) received the diagnosis of LS. In all patients with LS the histology was re-examined to confirm the clinical diagnosis. Retrograde and voiding urethrography was used to establish urethral involvement in the disease. Results: In 106 patients (82%) the histology provided the classical features of LS, and 24 patients (18%) showed some histological variations. In 49 patients (37%) the LS involved the pendolous urethra (meatus-navicularis-penile), and in 53 cases (41%) a panurethral stricture was evident. Conclusions: LS urethral involvement appears to be a much more common and extensive disease than previously reported, and requires particular care in its early diagnosis.

[1]  C. Kreibich,et al.  Lichen sclerosus , 2005, Archiv für Dermatologie und Syphilis.

[2]  F. Sampaio,et al.  Regional differences in the extracellular matrix of the human spongy urethra as evidenced by the composition of glycosaminoglycans. , 2002, The Journal of urology.

[3]  F. Wojnarowska,et al.  High incidence of lichen sclerosus in patients with squamous cell carcinoma of the penis , 2001, The British journal of dermatology.

[4]  Derek T P Evans.  Retrospective study of male lichen sclerosus and outcome in Leicester: 1995–9 inclusive: experience of a genitourinary medicine clinic , 2000, Sexually transmitted infections.

[5]  I. Depasquale,et al.  The treatment of balanitis xerotica obliterans , 2000, BJU international.

[6]  A. Edwards,et al.  Clinical features of lichen sclerosus in men attending a department of genitourinary medicine , 2000, Sexually transmitted infections.

[7]  D. Hawkins,et al.  Circumcision and genital dermatoses. , 2000, Archives of dermatology.

[8]  G. Micali,et al.  Penile cancer among patients with genital lichen sclerosus. , 1999, Journal of the American Academy of Dermatology.

[9]  J. Bonnetblanc,et al.  [Penile lichen sclerosus: follow-up study]. , 1999, Annales de dermatologie et de venereologie.

[10]  M. Lazzeri,et al.  Lichen sclerosis of male genitalia involving anterior urethra , 1999, The Lancet.

[11]  G. Barbagli,et al.  LICHEN SCLEROSUS INVOLVING ANTERIOR URETHRA , 1999 .

[12]  A. Mundy,et al.  Urethroplasty for balanitis xerotica obliterans. , 1998, British journal of urology.

[13]  S. J. Lee,et al.  Recurrent lichen sclerosus et atrophicus in urethroplasties from multiple skin grafts. , 1994, British journal of urology.

[14]  M. Nathan,et al.  Lichen sclerosus and acute urinary obstruction. , 1992, Genitourinary medicine.

[15]  O. Bouchot,et al.  Le phimosis acquis, ou lichen scléro-atrophique préputial de l'enfant. , 1991 .

[16]  J. Stalder,et al.  [Acquired phimosis, or preputial sclero-atrophic lichen in children]. , 1991, Journal de chirurgie.

[17]  D. Weigand,et al.  Late circumcision and lichen sclerosus et atrophicus of the penis. , 1989, Journal of the American Academy of Dermatology.

[18]  J. Bressieux,et al.  [Lichen sclerosus et atrophicus and stricture of the meatus in a child]. , 1989, Annales de dermatologie et de venereologie.

[19]  M. Stower,et al.  Urethral strictures in childhood. , 1988, British journal of urology.

[20]  O. Clemmensen,et al.  The Histologic Spectrum of Prepuces from Patients with Phimosis , 1988, The American Journal of dermatopathology.

[21]  F. Algaba,et al.  Balanitis xerotica obliterans in children. , 1986, The Journal of urology.

[22]  A. Rickwood,et al.  Phimosis in boys. , 1980, British journal of urology.

[23]  S. Herschorn,et al.  Balanitis xerotica obliterans involving anterior urethra. , 1979, Urology.

[24]  J. M. Garat,et al.  Urethro-balanitis xerotica obliterans. , 1978, European urology.

[25]  B. Post,et al.  [Lichen sclerosus et atrophicus penis]. , 1975, Zeitschrift fur Hautkrankheiten.

[26]  R. Whitaker,et al.  Balanitis xerotica obliterans and urinary obstruction. , 1971, British journal of urology.

[27]  W. G. Staff,et al.  Urethral involvement in balanitis xerotica obliterans. , 1970, British journal of urology.

[28]  P. Samman,et al.  Balanitis Xerotica Obliterans , 1949, Proceedings of the Royal Society of Medicine.