Deprescribing anticholinergics in primary care older adults: Experience from two models and impact on a continuous measure of exposure

Deprescribing interventions delivered through the electronic medical record have not significantly reduced the use of high‐risk anticholinergics in prior trials. Pharmacists have been identified as ideal practitioners to conduct deprescribing; however, little experience beyond collaborative consult models has been published.

[1]  N. Campbell,et al.  A 12-Year Retrospective Study of the Prevalence of Anticholinergic Polypharmacy and Associated Outcomes Among Medicare Patients with Overactive Bladder in the USA , 2021, Drugs & Aging.

[2]  M. Boustani,et al.  Multicomponent behavioral intervention to reduce exposure to anticholinergics in primary care older adults , 2021, Journal of the American Geriatrics Society.

[3]  G. Jicha,et al.  One-Year Evaluation of a Targeted Medication Therapy Management Intervention for Older Adults , 2020, Journal of managed care & specialty pharmacy.

[4]  Y. Loke,et al.  Interventions to Reduce Anticholinergic Burden in Adults Aged 65 and Older: A Systematic Review. , 2020, Journal of the American Medical Directors Association.

[5]  M. Boustani,et al.  Preventing Alzheimer Disease by Deprescribing Anticholinergic Medications. , 2019, JAMA internal medicine.

[6]  J. Hippisley-Cox,et al.  Anticholinergic Drug Exposure and the Risk of Dementia , 2019, JAMA internal medicine.

[7]  M. Boustani,et al.  Pharmacological Management of Delirium in the Intensive Care Unit: A Randomized Pragmatic Clinical Trial , 2019, Journal of the American Geriatrics Society.

[8]  J. Hanlon,et al.  American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults , 2019, Journal of the American Geriatrics Society.

[9]  Lisa G. Pont,et al.  Reducing the anticholinergic and sedative load in older patients on polypharmacy by pharmacist-led medication review: a randomised controlled trial , 2018, BMJ Open.

[10]  Sujuan Gao,et al.  Anticholinergics Influence Transition from Normal Cognition to Mild Cognitive Impairment in Older Adults in Primary Care , 2018, Pharmacotherapy.

[11]  Carol Brayne,et al.  Anticholinergic drugs and risk of dementia: case-control study , 2018, BMJ.

[12]  G. Jicha,et al.  Optimizing medication appropriateness in older adults: a randomized clinical interventional trial to decrease anticholinergic burden , 2017, Alzheimer's Research & Therapy.

[13]  Jamie L Statz-Paynter,et al.  Evaluation of a pharmacist-led pilot service based on the anticholinergic risk scale. , 2016, Journal of the American Pharmacists Association : JAPhA.

[14]  S. Studenski,et al.  Anticholinergic Use and Recurrent Falls in Community-Dwelling Older Adults , 2015, The Annals of pharmacotherapy.

[15]  Danijela Gnjidic,et al.  Reducing inappropriate polypharmacy: the process of deprescribing. , 2015, JAMA internal medicine.

[16]  Sascha Dublin,et al.  Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. , 2015, JAMA internal medicine.

[17]  B. Guthrie,et al.  Temporal trends in anticholinergic medication prescription in older people: repeated cross-sectional analysis of population prescribing data. , 2014, Age and ageing.

[18]  Christopher M. Callahan,et al.  Enhancing Care for Hospitalized Older Adults with Cognitive Impairment: A Randomized Controlled Trial , 2012, Journal of General Internal Medicine.

[19]  Cathy C Schubert,et al.  Implementing innovative models of dementia care: The Healthy Aging Brain Center , 2011, Aging & mental health.

[20]  M. Boustani,et al.  Use of anticholinergics and the risk of cognitive impairment in an African American population , 2010, Neurology.

[21]  Yazan F. Roumani,et al.  Number and dosage of central nervous system medications on recurrent falls in community elders: the Health, Aging and Body Composition study. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[22]  M. Boustani,et al.  Impact of anticholinergics on the aging brain: a review and practical application , 2008 .

[23]  E. Wagner,et al.  Is the Use of Benzodiazepines Associated with Incident Disability? , 2002, Journal of the American Geriatrics Society.

[24]  M. Higbee,et al.  Geriatric Dosage Handbook , 2001 .

[25]  M. A. O. Ignacio,et al.  How to cite this article , 2016 .