New TRP Channels in Hearing and Mechanosensation

Despite extensive biophysical characterization and the superb example of the bacterial MscL channel, molecular identification of eukaryotic mechanosensitive channels has been slow. New members of the TRP superfamily have emerged as candidate channels to mediate touch, hearing, fluid flow, and osmosensation in sensory and nonsensory cells. Distinguishing between direct mechanical activation and indirect second messenger activation is still a challenge.

[1]  G. Pazour,et al.  Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease , 2002, Current Biology.

[2]  J. T. Corwin,et al.  Lighting up the Senses: FM1-43 Loading of Sensory Cells through Nonselective Ion Channels , 2003, The Journal of Neuroscience.

[3]  B. Nilius,et al.  The TRPV4 channel: structure-function relationship and promiscuous gating behaviour , 2003, Pflügers Archiv.

[4]  Boris Martinac,et al.  A large-conductance mechanosensitive channel in E. coli encoded by mscL alone , 1994, Nature.

[5]  L. Guay-Woodford,et al.  The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. , 2002, Journal of the American Society of Nephrology : JASN.

[6]  C. Zuker,et al.  Genetic dissection of mechanosensory transduction: Mechanoreception-defective mutations of drosophila , 1994, Neuron.

[7]  Paul W. Sternberg,et al.  A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans , 1999, Nature.

[8]  Cori Bargmann,et al.  Combinatorial Expression of TRPV Channel Proteins Defines Their Sensory Functions and Subcellular Localization in C. elegans Neurons , 2002, Neuron.

[9]  B. Minke,et al.  TRP channel proteins and signal transduction. , 2002, Physiological reviews.

[10]  Maurice J. Kernan,et al.  A TRPV family ion channel required for hearing in Drosophila , 2003, Nature.

[11]  M. Arnaout Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease. , 2001, Annual review of medicine.

[12]  A. Hudspeth,et al.  Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor , 2000, Cell.

[13]  Maurice J. Kernan,et al.  Genetically Similar Transduction Mechanisms for Touch and Hearing in Drosophila , 2000, The Journal of Neuroscience.

[14]  P Facer,et al.  Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. , 2001, Physiological genomics.

[15]  K. Steel Varitint-waddler: A double whammy for hearing , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[16]  J. Levine,et al.  Hypotonicity Induces TRPV4-Mediated Nociception in Rat , 2003, Neuron.

[17]  G. Germino,et al.  Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents , 2000, Nature.

[18]  G. Schultz,et al.  OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity , 2000, Nature Cell Biology.

[19]  K. R. Spring,et al.  Bending the MDCK Cell Primary Cilium Increases Intracellular Calcium , 2001, The Journal of Membrane Biology.

[20]  C. Zuker,et al.  A Drosophila mechanosensory transduction channel. , 2000, Science.

[21]  D. Hall,et al.  The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway , 2001, Current Biology.

[22]  Jing Zhou,et al.  Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells , 2003, Nature Genetics.

[23]  Rainer W Friedrich,et al.  NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction , 2003, Science.

[24]  Cori Bargmann,et al.  OSM-9, A Novel Protein with Structural Similarity to Channels, Is Required for Olfaction, Mechanosensation, and Olfactory Adaptation inCaenorhabditis elegans , 1997, The Journal of Neuroscience.

[25]  M. Freichel,et al.  Trp12, a novel Trp related protein from kidney , 2000, FEBS letters.