about her condition. At first irritable, while mentally very alert, with rapid breathing and fits of screaming, she was admitted to hospital twenty-four hours after the ingestion of the aspirin. Her clinical picture, with deep rapid respirations 48 per minute, flushed face, and vomiting, was compatible with a diagnosis of acidosis; yet this was not confirmed by investigation. The alkali reserve was 50 volumes per cent., and the urine gave negative reactions to Gerhardt's and Rothera's tests. The treatment given was 8 ounces (227 c.cm.) of 2 per cent. glucose and saline solution intravenously, and 1 pint (568 c.cm.) of 10 per cent. glucose and 0.9 per cent. sodium bicarbonate solution orally during the first twelve hours. The child's breathing remained deep, and the rate was 40 per minute; she was still irritable. Ihe alkali reserve had fallen to 29 volumes per cent. and the urine gave positive reactions to Gerhardt's and Rothera's tests, showing that a state of acidosis had developed. Twenty-six ounces (738 c.cm.) of sodium lactate solution and 17 ounces (447 c.cm.) of 10 per cent. glucose and saline solution were given by the slow-drip method intravenously in twenty hours, the patient showing considerable improvement. She was able to take a normal light diet, and appeared quite well after a further three days.