Differential roles of STAT3 in the initiation and growth of lung cancer

[1]  J. Grandis,et al.  Critical analysis of the potential for targeting STAT3 in human malignancy , 2013, OncoTargets and therapy.

[2]  Ming Li,et al.  The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis. , 2013, Neoplasia.

[3]  Yunbao Pan,et al.  Stat3 Inhibitor Stattic Exhibits Potent Antitumor Activity and Induces Chemo- and Radio-Sensitivity in Nasopharyngeal Carcinoma , 2013, PloS one.

[4]  A. Jemal,et al.  Cancer statistics, 2013 , 2013, CA: a cancer journal for clinicians.

[5]  J. Fagin,et al.  STAT3 negatively regulates thyroid tumorigenesis , 2012, Proceedings of the National Academy of Sciences.

[6]  G. Xiao,et al.  PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease , 2012, Cell & Bioscience.

[7]  Simion I. Chiosea,et al.  First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: implications for cancer therapy. , 2012, Cancer discovery.

[8]  Kenji Mizuguchi,et al.  Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis. , 2012, Cancer research.

[9]  Weiwei Li,et al.  Expression and prognostic relevance of STAT3 and cyclin D1 in non-small cell lung cancer , 2012, The International journal of biological markers.

[10]  Yun Lu,et al.  Evidence for type II cells as cells of origin of K-Ras–induced distal lung adenocarcinoma , 2012, Proceedings of the National Academy of Sciences.

[11]  Lei-na Sun,et al.  Correlation of Activated STAT3 Expression with Clinicopathologic Features in Lung Adenocarcinoma and Squamous Cell Carcinoma , 2011, Molecular Diagnosis & Therapy.

[12]  D. Neuberg,et al.  A dual role for the immune response in a mouse model of inflammation-associated lung cancer. , 2011, The Journal of clinical investigation.

[13]  W. Young,et al.  Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3β-NF-AT signaling , 2011, Cell & Bioscience.

[14]  M. Karin,et al.  The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. , 2011, Cancer cell.

[15]  P. Yan,et al.  Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis , 2010, Oncogene.

[16]  U. Dafni,et al.  Nuclear Localization of Signal Transducer and Activator of Transcription 3 in Head and Neck Squamous Cell Carcinoma Is Associated with a Better Prognosis , 2010, Clinical Cancer Research.

[17]  Jing Jiang,et al.  DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. , 2010, Cancer research.

[18]  E. Casanova,et al.  Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. , 2010, Gastroenterology.

[19]  Jing Hu,et al.  Epigenetic Repression of PDZ-LIM Domain-containing Protein 2 , 2010, The Journal of Biological Chemistry.

[20]  J. Nevins,et al.  Age- and sex-specific genomic profiles in non-small cell lung cancer. , 2010, JAMA.

[21]  Hua Yu,et al.  STATs in cancer inflammation and immunity: a leading role for STAT3 , 2009, Nature Reviews Cancer.

[22]  G. Xiao,et al.  Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. , 2009, Neoplasia.

[23]  G. Xiao,et al.  PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. , 2009, Blood.

[24]  W. Pao,et al.  KRAS mutations in non-small cell lung cancer. , 2009, Proceedings of the American Thoracic Society.

[25]  M. Karin,et al.  IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. , 2009, Cancer cell.

[26]  S. Lippman,et al.  Lung cancer. , 2008, The New England journal of medicine.

[27]  Youn-Hee Choi,et al.  Loss of Protein Inhibitors of Activated STAT-3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression , 2008, Clinical Cancer Research.

[28]  David E Levy,et al.  Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. , 2008, Genes & development.

[29]  O. Cummings,et al.  Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung. , 2007, Cancer research.

[30]  Kenneth Leslie,et al.  Constitutively Activated Stat3 Induces Tumorigenesis and Enhances Cell Motility of Prostate Epithelial Cells through Integrin β6 , 2007, Molecular and Cellular Biology.

[31]  G. Xiao,et al.  Endoproteolytic processing of C-terminally truncated NF-κB2 precursors at κB-containing promoters , 2007, Proceedings of the National Academy of Sciences.

[32]  K. Kinzler,et al.  Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T , 2007, Proceedings of the National Academy of Sciences.

[33]  T. Perfetti,et al.  Perspectives on Pulmonary Inflammation and Lung Cancer Risk in Cigarette Smokers , 2006, Inhalation toxicology.

[34]  G. Xiao,et al.  Stabilization of Basally Translated NF-κB-inducing Kinase (NIK) Protein Functions as a Molecular Switch of Processing of NF-κB2 p100* , 2005, Journal of Biological Chemistry.

[35]  K. Kiguchi,et al.  Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. , 2004, The Journal of clinical investigation.

[36]  C. Harris,et al.  Radical causes of cancer , 2003, Nature Reviews Cancer.

[37]  David L Rimm,et al.  Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[38]  J. Shannon,et al.  Maintenance of the mouse type II cell phenotype in vitro. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[39]  Stephen S Hecht,et al.  Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention. , 2002, The Lancet. Oncology.

[40]  T. Jacks,et al.  Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. , 2001, Genes & development.

[41]  J. Darnell,et al.  Stat3 as an Oncogene , 1999, Cell.

[42]  T. Jacks,et al.  Modeling human lung cancer in mice: similarities and shortcomings , 1999, Oncogene.

[43]  Y. Yano,et al.  The activation of K-ras gene at an early stage of lung tumorigenesis in mice. , 1996, Cancer letters.

[44]  A. Brody,et al.  Isolation and primary culture of murine alveolar type II cells. , 1996, American journal of respiratory cell and molecular biology.

[45]  R. Jove,et al.  Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. , 1995, Science.

[46]  H. Witschi,et al.  Mutations of the Ki-ras protooncogene in 3-methylcholanthrene and urethan-induced and butylated hydroxytoluene-promoted lung tumors of strain A/J and SWR mice. , 1995, Cancer letters.

[47]  松崎 陽平 Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection , 2007 .

[48]  S. Akira,et al.  Stat-3 is required for pulmonary homeostasis during hyperoxia. , 2004, The Journal of clinical investigation.

[49]  H. Hansen,et al.  Lung cancer. , 1990, Cancer chemotherapy and biological response modifiers.

[50]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.