A Carotane Sesquiterpene as a Potent Modulator of the Maxi-K Channel from Arthrinium phaesospermum

Abstract A potent modulator of the Maxi-K channel, isolated from Arthrinium phaeospermum , has been determined to be a carotane sesquiterpene by spectroscopic means. X-ray crystallographic studies demonstrated this compound as being identical to CAF-603, previously discovered as an antifungal agent.