Heterologous desensitization is evoked by both agonist and antagonist stimulation of the human 5-HT(7) serotonin receptor.
暂无分享,去创建一个
[1] I. Oye,et al. A radioimmunoassay for cyclic AMP (cAMP) obtained by acetylation of both unlabeled and labeled (3H-cAMP) ligand, or of unlabeled ligand only. , 2009, Acta pharmacologica et toxicologica.
[2] A. Franklin,et al. Differential Agonist-Mediated Internalization of the Human 5-Hydroxytryptamine 7 Receptor Isoforms , 2005, Journal of Pharmacology and Experimental Therapeutics.
[3] J. Norum,et al. Endogenous expression and protein kinase A‐dependent phosphorylation of the guanine nucleotide exchange factor Ras‐GRF1 in human embryonic kidney 293 cells , 2005, The FEBS journal.
[4] Terry Kenakin,et al. Ligand-selective receptor conformations revisited: the promise and the problem. , 2003, Trends in pharmacological sciences.
[5] I. Sjaastad,et al. Increased contribution of α1‐ vs. β‐adrenoceptor‐mediated inotropic response in rats with congestive heart failure , 2003 .
[6] F. Lezoualc’h,et al. Characterization of human 5‐HT4(d) receptor desensitization in CHO cells , 2003, British journal of pharmacology.
[7] K. Krobert,et al. The human 5‐HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects , 2002, British journal of pharmacology.
[8] J. Hensler,et al. Mechanisms of ligand-induced desensitization of the 5-hydroxytryptamine(2A) receptor. , 2002, The Journal of pharmacology and experimental therapeutics.
[9] J. Regan,et al. Phosphorylation of Glycogen Synthase Kinase-3 and Stimulation of T-cell Factor Signaling following Activation of EP2 and EP4 Prostanoid Receptors by Prostaglandin E2 * , 2002, The Journal of Biological Chemistry.
[10] P. Prather,et al. Chronic exposure to mu-opioid agonists produces constitutive activation of mu-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. , 2001, Molecular pharmacology.
[11] K. Krobert,et al. The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution , 2001, Naunyn-Schmiedeberg's Archives of Pharmacology.
[12] J. Neumaier,et al. Clozapine downregulates 5-hydroxytryptamine6 (5-HT6) and upregulates 5-HT7 receptors in HeLa cells , 2000, Neuroscience Letters.
[13] J. Hagan,et al. [3H]‐SB‐269970 – A selective antagonist radioligand for 5‐HT7 receptors , 2000 .
[14] Y. Oron,et al. Rapid desensitization of the TRH receptor and persistent desensitization of its constitutively active mutant , 2000, British journal of pharmacology.
[15] D. Schmidt-Grimminger,et al. Presence of a 5-HT7 receptor positively coupled to adenylate cyclase activation in human granulosa-lutein cells. , 2000, The Journal of clinical endocrinology and metabolism.
[16] Y. Oron,et al. Inverse agonist abolishes desensitization of a constitutively active mutant of thyrotropin‐releasing hormone receptor: role of cellular calcium and protein kinase C , 1999, British journal of pharmacology.
[17] T. Branchek,et al. Functional characterization of the recombinant human 5-hydroxytryptamine7(a) receptor isoform coupled to adenylate cyclase stimulation. , 1998, The Journal of pharmacology and experimental therapeutics.
[18] Robert J. Lefkowitz,et al. G Protein-coupled Receptors , 1998, The Journal of Biological Chemistry.
[19] J. Hagan,et al. Functional characterisation of the human cloned 5‐HT7 receptor (long form); antagonist profile of SB‐258719 , 1998, British journal of pharmacology.
[20] R. Leurs,et al. Modulation of forskolin‐mediated adenylyl cyclase activation by constitutively active Gs‐coupled receptors , 1997, FEBS letters.
[21] G. Milligan,et al. Up-regulation of the levels of expression and function of a constitutively active mutant of the hamster alpha1B-adrenoceptor by ligands that act as inverse agonists. , 1997, The Biochemical journal.
[22] L. Miller,et al. Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor. , 1997, Molecular pharmacology.
[23] G. Milligan,et al. Up‐regulation of a constitutively active form of the β 2‐adrenoceptor by sustained treatment with inverse agonists but not antagonists , 1996, FEBS letters.
[24] R. Leurs,et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[25] P. Chidiac,et al. Serotonergic antagonists differentially inhibit spontaneous activity and decrease ligand binding capacity of the rat 5-hydroxytryptamine type 2C receptor in Sf9 cells. , 1995, Molecular pharmacology.
[26] E. sanders-Bush,et al. Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands. , 1994, The Journal of biological chemistry.
[27] R. Lefkowitz,et al. A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[28] M. Lohse,et al. Molecular mechanisms of membrane receptor desensitization. , 1993, Biochimica et biophysica acta.
[29] R. Lefkowitz. G protein—coupled receptor kinases , 1993, Cell.
[30] M. Pranzatelli,et al. Novel regulation of 5-HT1C receptors: down-regulation induced both by 5-HT1C/2 receptor agonists and antagonists. , 1993, European journal of pharmacology.
[31] J. Bockaert,et al. Characterization of homologous 5-hydroxytryptamine4 receptor desensitization in colliculi neurons. , 1992, Molecular pharmacology.
[32] D. Sibley,et al. Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. , 1987, Archives of biochemistry and biophysics.
[33] D. Sibley,et al. Regulation of transmembrane signaling by receptor phosphorylation , 1987, Cell.
[34] T. Nakamura,et al. Mechanism of heterologous desensitization of the adenylate cyclase system by glucagon in primary cultures of adult rat hepatocytes. , 1984, The Journal of biological chemistry.
[35] A. Herbet,et al. In vitro and in vivo disposition of 3H-methiothepin in brain tissues , 1979, Naunyn-Schmiedeberg's Archives of Pharmacology.
[36] K. Krobert,et al. Unaltered agonist potency upon inducible 5-HT7(a) but not 5-HT4(b) receptor expression indicates agonist-independent association of 5-HT7(a) receptor and Gs. , 2003, Receptors & channels.
[37] Daly Jw,et al. Forskolin: its biological and chemical properties. , 1986, Advances in cyclic nucleotide and protein phosphorylation research.
[38] D. Sibley,et al. Receptor adaptations to centrally acting drugs. , 1981, Annual review of pharmacology and toxicology.