We report on the use of qualitative research in the design of video-based interventions aimed at reducing AIDS and other sexually transmitted diseases (STDs) among inner-city Hispanics. Focus groups, personal interviews, and clinic observations were conducted in the South Bronx and Queens, New York, to inform the development of culturally sensitive video-based materials for improving prevention education provided at inner-city STD clinics. Findings elucidate culturally defined gender roles and responsibilities regarding the introduction of condom use into primary and nonprimary relationships, as well as other norms, attitudes, and behaviors reducing the effectiveness of current AIDS and other STD prevention efforts. Too often, educational materials--including an increasing number of videos--are based on untested assumptions about what information should be provided rather than adequate formative research. One reason may be that the literature contains few accounts of how the empirical evidence obtained through such research can be translated into theoretically sound interventions. This paper explicates such a process.