An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance.

[1]  Daniel R. Beisner,et al.  Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor , 2009, Nature Immunology.

[2]  W. Leonard,et al.  Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. , 2008, Blood.

[3]  V. Lazar,et al.  FOXO1 Regulates L-Selectin and a Network of Human T Cell Homing Molecules Downstream of Phosphatidylinositol 3-Kinase1 , 2008, The Journal of Immunology.

[4]  M. Farrar,et al.  IL-2, -7, and -15, but Not Thymic Stromal Lymphopoeitin, Redundantly Govern CD4+Foxp3+ Regulatory T Cell Development1 , 2008, The Journal of Immunology.

[5]  R. Flavell,et al.  TGF-β: A Master of All T Cell Trades , 2008, Cell.

[6]  T. Malek,et al.  A Function for IL-7R for CD4+CD25+Foxp3+ T Regulatory Cells1 , 2008, The Journal of Immunology.

[7]  T. Nomura,et al.  Regulatory T Cells and Immune Tolerance , 2008, Cell.

[8]  Nikhil S. Joshi,et al.  Formation of IL-7Ralphahigh and IL-7Ralphalow CD8 T cells during infection is regulated by the opposing functions of GABPalpha and Gfi-1. , 2008, Journal of immunology.

[9]  S. Peng,et al.  Foxo in the immune system , 2008, Oncogene.

[10]  T. Obsil,et al.  Structure/function relationships underlying regulation of FOXO transcription factors , 2008, Oncogene.

[11]  B. Burgering,et al.  A brief introduction to FOXOlogy , 2008, Oncogene.

[12]  Tak W. Mak,et al.  CD4 T cells, lymphopenia, and IL-7 in a multistep pathway to autoimmunity , 2008, Proceedings of the National Academy of Sciences.

[13]  E. Sebzda,et al.  Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns , 2008, Nature Immunology.

[14]  Chen Dong,et al.  T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. , 2008, Immunity.

[15]  S. Rosenberg,et al.  Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling. , 2007, The Journal of clinical investigation.

[16]  D. Tindall,et al.  Dynamic FoxO transcription factors , 2007, Journal of Cell Science.

[17]  R. Mazzucchelli,et al.  Interleukin-7 receptor expression: intelligent design , 2007, Nature Reviews Immunology.

[18]  R. Flavell,et al.  Transforming Growth Factor-β Controls Development, Homeostasis, and Tolerance of T Cells by Regulatory T Cell-Dependent and -Independent Mechanisms , 2006 .

[19]  Corey M. Carlson,et al.  Kruppel-like factor 2 regulates thymocyte and T-cell migration , 2006, Nature.

[20]  P. Burkett,et al.  Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. , 2006, Annual review of immunology.

[21]  P. Kaldis,et al.  IL-7 promotes T cell proliferation through destabilization of p27Kip1 , 2006, The Journal of experimental medicine.

[22]  R. Flavell,et al.  Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. , 2006, Immunity.

[23]  E. Wherry,et al.  Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin , 2005, Nature Immunology.

[24]  N. Sarvetnick,et al.  T cell homeostasis in tolerance and immunity , 2005, Journal of leukocyte biology.

[25]  Q. Jiang,et al.  Cell biology of IL-7, a key lymphotrophin. , 2005, Cytokine & growth factor reviews.

[26]  J. Sprent,et al.  Regulation of mature T cell homeostasis. , 2005, Seminars in immunology.

[27]  Y. Wan,et al.  Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[28]  A. Trautmann,et al.  Stable Activation of Phosphatidylinositol 3-Kinase in the T Cell Immunological Synapse Stimulates Akt Signaling to FoxO1 Nuclear Exclusion and Cell Growth Control1 , 2005, The Journal of Immunology.

[29]  S. Nishikawa,et al.  Abnormal Angiogenesis in Foxo1 (Fkhr)-deficient Mice* , 2004, Journal of Biological Chemistry.

[30]  A. Singer,et al.  Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. , 2004, Immunity.

[31]  Jonathan D. Hron,et al.  Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. , 2004, Immunity.

[32]  C. Benoist,et al.  Back to central tolerance. , 2004, Immunity.

[33]  N. Sarvetnick,et al.  Homeostatic Expansion of T Cells during Immune Insufficiency Generates Autoimmunity , 2004, Cell.

[34]  Hermann Wagner,et al.  Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[35]  W. Biggs,et al.  Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[36]  W. Leonard,et al.  GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. , 2004, Nature Immunology.

[37]  S. Swain,et al.  IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells , 2003, The Journal of experimental medicine.

[38]  L. Bradley,et al.  Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells , 2003, The Journal of experimental medicine.

[39]  E. Wherry,et al.  Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells , 2003, Nature Immunology.

[40]  D. Fruman,et al.  Regulation of quiescence in lymphocytes. , 2003, Trends in immunology.

[41]  Benedict Seddon,et al.  Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells , 2003, Nature Immunology.

[42]  T. Möröy,et al.  The Transcriptional Repressor Gfi1 Affects Development of Early, Uncommitted c-Kit+ T Cell Progenitors and CD4/CD8 Lineage Decision in the Thymus , 2003, The Journal of experimental medicine.

[43]  Leo Lefrançois,et al.  Cytokine control of memory T-cell development and survival , 2003, Nature Reviews Immunology.

[44]  Stephen C. Jameson,et al.  Maintaining the norm: T-cell homeostasis , 2002, Nature Reviews Immunology.

[45]  W. Sellers,et al.  A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. , 2002, Cancer cell.

[46]  J. Sprent,et al.  Overexpression of Interleukin (IL)-7 Leads to IL-15–independent Generation of Memory Phenotype CD8+ T Cells , 2002, The Journal of experimental medicine.

[47]  W. M. Weaver,et al.  A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. , 2001, Immunity.

[48]  J. Barata,et al.  Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1). , 2001, Blood.

[49]  Richard Murray,et al.  IL-7 is critical for homeostatic proliferation and survival of naïve T cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[50]  R. Flavell,et al.  GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. , 2001, Immunity.

[51]  S. Jameson,et al.  Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo , 2000, Nature Immunology.

[52]  R. Medema,et al.  AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 , 2000, Nature.

[53]  B. Kwon,et al.  Role of 4-1BB in immune responses. , 1998, Seminars in immunology.

[54]  I. Weissman,et al.  Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice , 1997, Cell.

[55]  A. Strasser,et al.  Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice , 1997, Cell.