Ion Permeability of the Nuclear Envelope.

The nuclear envelope mediates nucleocytoplasmic communication. Nuclear pores transport proteins and RNA into and out of the nucleus. The pore is believed to allow free ion diffusion. Using an electrophysiological approach, we show the possible semipermeable properties of the envelope. To accomplish these functions we hypothesize a mechanism in which the pore complex acts as a molecular diaphragm.

[1]  D. Clapham,et al.  Conformational States of the Nuclear Pore Complex Induced by Depletion of Nuclear Ca2+ Stores , 1996, Science.

[2]  P. Csermely,et al.  Signalling and transport through the nuclear membrane. , 1995, Biochimica et biophysica acta.

[3]  O. Gerasimenko,et al.  ATP-dependent accumulation and inositol trisphosphate- or cyclic ADP-ribose-mediated release of Ca2+ from the nuclear envelope , 1995, Cell.

[4]  D. Clapham,et al.  Calcium release from the nucleus by InsP3 receptor channels , 1995, Neuron.

[5]  M. Mazzanti,et al.  ATP‐dependent ionic permeability on nuclear envelope in in situ nuclei of Xenopus oocytes , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  G. Blobel,et al.  The GTP-binding protein Ran/TC4 is required for protein import into the nucleus , 1993, Nature.

[7]  Ronald A. Milligan,et al.  Architecture and design of the nuclear pore complex , 1992, Cell.

[8]  M. Matzke,et al.  Detection of a large cation‐selective channel in nuclear envelopes of avian erythrocytes , 1990, FEBS letters.

[9]  L. DeFelice,et al.  Ion channels in the nuclear envelope , 1990, Nature.

[10]  M. Schindler,et al.  Nuclear actin and myosin as control elements in nucleocytoplasmic transport , 1986, The Journal of cell biology.

[11]  S. Ito,et al.  Permeability of a Nuclear Membrane: Changes during Normal Development and Changes Induced by Growth Hormone , 1965, Science.

[12]  L. Monné.  Permeability of the Nuclear Membrane to Vital Stains , 1935 .