The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity

[1]  Hatice S. Kaya-Okur,et al.  CUT&Tag for efficient epigenomic profiling of small samples and single cells , 2019, Nature Communications.

[2]  X. Bian,et al.  Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction , 2019, Nature.

[3]  Paul Bertone,et al.  The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression , 2018, Molecular cell.

[4]  H. Cantor,et al.  Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells , 2018, Proceedings of the National Academy of Sciences.

[5]  Zheng Wei,et al.  esATAC: an easy-to-use systematic pipeline for ATAC-seq data analysis , 2018, Bioinform..

[6]  F. Mami-Chouaib,et al.  Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy , 2018, Front. Immunol..

[7]  Purvesh Khatri,et al.  Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes , 2017, Cell.

[8]  S. Lewin,et al.  Immune checkpoint blockade in infectious diseases , 2017, Nature Reviews Immunology.

[9]  Paul G. Thomas,et al.  De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation , 2017, Cell.

[10]  J. Leitner,et al.  PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells , 2017, Front. Immunol..

[11]  J. Wolchok,et al.  Combination immunotherapy: a road map , 2017, Journal of Immunotherapy for Cancer.

[12]  I. Mellman,et al.  Elements of cancer immunity and the cancer–immune set point , 2017, Nature.

[13]  A. Elkahloun,et al.  The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness , 2016, Science Immunology.

[14]  W. Linehan,et al.  Ionic immune suppression within the tumour microenvironment limits T cell effector function , 2016, Nature.

[15]  X. Chen,et al.  The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation , 2015, Nature Immunology.

[16]  José A. Dianes,et al.  2016 update of the PRIDE database and its related tools , 2015, Nucleic Acids Res..

[17]  Yuxin Yin,et al.  PTEN regulates RPA1 and protects DNA replication forks , 2015, Cell Research.

[18]  G. Freeman,et al.  Combination cancer immunotherapy and new immunomodulatory targets , 2015, Nature Reviews Drug Discovery.

[19]  B. Klaholz,et al.  Structure and function insights into the NuRD chromatin remodeling complex , 2015, Cellular and Molecular Life Sciences.

[20]  R. Chung,et al.  Hepatitis C virus-associated cancer. , 2015, Annual review of pathology.

[21]  Howard Y. Chang,et al.  ATAC‐seq: A Method for Assaying Chromatin Accessibility Genome‐Wide , 2015, Current protocols in molecular biology.

[22]  B. Levine,et al.  Adoptive immunotherapy for cancer or viruses. , 2014, Annual review of immunology.

[23]  Huidong Shi,et al.  MBD3 Localizes at Promoters, Gene Bodies and Enhancers of Active Genes , 2013, PLoS genetics.

[24]  T. Mak,et al.  Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.

[25]  E. Elinav,et al.  Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms , 2013, Nature Reviews Cancer.

[26]  Benjamin E. Gross,et al.  Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal , 2013, Science Signaling.

[27]  S. Snyder,et al.  Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death , 2013, Science Signaling.

[28]  Lieping Chen,et al.  Molecular mechanisms of T cell co-stimulation and co-inhibition , 2013, Nature Reviews Immunology.

[29]  M. Lederman,et al.  Decreased IL-7 Responsiveness Is Related to Oxidative Stress in HIV Disease , 2013, PloS one.

[30]  T. Mak,et al.  Reactive oxygen species delay control of lymphocytic choriomeningitis virus , 2013, Cell Death and Differentiation.

[31]  R. Schreiber,et al.  Timing and magnitude of type I interferon responses by distinct sensors impact CD8 T cell exhaustion and chronic viral infection. , 2012, Cell host & microbe.

[32]  Norman E. Davey,et al.  Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins , 2012, Cell.

[33]  Y. Levy.  Intrinsically disordered regions as affinity tuners in protein–DNA interactions , 2012 .

[34]  Helga Thorvaldsdóttir,et al.  Integrative Genomics Viewer , 2011, Nature Biotechnology.

[35]  Z. Szallasi,et al.  An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients , 2010, Breast Cancer Research and Treatment.

[36]  Michael D. Wilson,et al.  ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. , 2009, Methods.

[37]  C. Rouzioux,et al.  Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. , 2009, The Journal of clinical investigation.

[38]  J. Glover,et al.  RAD18 transmits DNA damage signaling to elicit homologous recombination repair , 2009, Nature Cell Biology.

[39]  Brad T. Sherman,et al.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.

[40]  Markus F Neurath,et al.  An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression , 2007, Nature Protocols.

[41]  Jerry L. Workman,et al.  Histone acetyltransferase complexes: one size doesn't fit all , 2007, Nature Reviews Molecular Cell Biology.

[42]  J. Mesirov,et al.  From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005 .

[43]  M. Daly,et al.  PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes , 2003, Nature Genetics.

[44]  Antonio Lanzavecchia,et al.  T cell fitness determined by signal strength , 2003, Nature Immunology.

[45]  Stephen P. Schoenberger,et al.  Dynamic programming of CD8+ T lymphocyte responses , 2003, Nature Immunology.

[46]  C. Moskaluk,et al.  PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase. , 1993, Science.

[47]  R M Zinkernagel,et al.  Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. , 1991, Journal of virological methods.

[48]  H Jane Dyson,et al.  Roles of intrinsic disorder in protein-nucleic acid interactions. , 2012, Molecular bioSystems.

[49]  Y. Levy,et al.  Intrinsically disordered regions as affinity tuners in protein-DNA interactions. , 2012, Molecular bioSystems.

[50]  M. McCausland,et al.  Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. , 2008, Journal of virological methods.

[51]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[52]  R. Cardiff,et al.  Mammary Disease Mice Model Premalignant Polyoma Middle-T Transgenic Updated Version , 2001 .