Clinical Analysis of 152 Cases of Multiple Primary Malignant Tumors in 15,398 Patients with Malignant Tumors

Objectives In this study, the etiology, clinical characteristics, and prognosis of multiple primary malignant tumors (MPMTs) were investigated. Furthermore, we analyzed the treatment factors associated with MPMTs. Methods From 15,398 patients with malignant tumors presenting to The First Hospital of Jilin University, China, between January 2010 and December 2013, we identified and analyzed patients with MPMTs. Data were obtained retrospectively from the hospital database. Results The prevalence of MPMTs in this study was 0.99% (152/15398): 51 cases were synchronous MPMTs, and 101 cases were metachronous MPMTs. The mean time between the first and second primary cancer was 43.1 months. In this population, MPMTs were observed more frequently in patients with head and neck tumors (5.65%) and urinary tumors (4.19%); the prevalence of MPMTs in these patients was over 4-fold greater than the prevalence of MPMTs in all patients (0.99%). There were no cases of MPMTs in 132 cases of nervous system tumors and 404 cases of multiple myeloma. Nearly 50% (45.4%) of patients with MPMTs did not receive chemotherapy or radiotherapy before the second primary cancer was diagnosed. Eighty-five patients with MPMTs were followed for more than 2 years, and the 2-year cumulative survival rate was 40.8%. Conclusions In this study, the prevalence of MPMTs was 0.99% (152/15398), which is consistent with the Chinese literature. Patients with head and neck tumors or urinary tumors are at greater risk of developing MPMTs. In addition to radiotherapy or chemotherapy, this study suggests that other factors may contribute to MPMTs.

[1]  Q. Wei,et al.  Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers , 2013, Cancer.

[2]  N. Zengi̇n,et al.  Multiple primary malignant neoplasms: multi-center results from Turkey. , 2012, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[3]  M. Morita,et al.  Risk factors for multicentric occurrence of carcinoma in the upper aerodigestive tract—analysis with a serial histologic evaluation of the whole resected‐esophagus including carcinoma , 2003, Journal of surgical oncology.

[4]  Heidi D Nelson,et al.  Postmenopausal hormone replacement therapy: scientific review. , 2002, JAMA.

[5]  J. Frödin,et al.  Multiple primary malignant tumors in a national cancer registry--reliability of reporting. , 1997, Acta oncologica.

[6]  A. Neugut,et al.  The association of breast cancer and colorectal cancer in men. An analysis of surveillance, epidemiology, and end results program data , 1991, Cancer.

[7]  L. Ries,et al.  Leukemia following chemotherapy for breast cancer. , 1990, Cancer research.

[8]  H. Pan.  Clinical analysis of 155 cases of multiple primary malignant tumors , 1989 .

[9]  A. Schatzkin,et al.  Diet and cancer: Evidence from associations of multiple primary cancers in the seer program , 1988, Cancer.

[10]  T. Hiyama,et al.  Second primary cancers following female breast cancer in Osaka, Japan--a population-based cohort study. , 1987, Japanese journal of clinical oncology.

[11]  B. Henderson,et al.  A Prospective Study” , 2007 .

[12]  N. Day,et al.  Risk of leukaemia in ovarian tumour and breast cancer patients following treatment by cyclophosphamide. , 1987, British Journal of Cancer.

[13]  Brinton La,et al.  Second cancer following cancer of the breast in Connecticut, 1935-82. , 1985 .

[14]  L. Brinton,et al.  Second cancer following cancer of the breast in Connecticut, 1935-82. , 1985, National Cancer Institute monograph.

[15]  T. Hirayama.  Diet and cancer , 1979 .

[16]  Liu Fs,et al.  [A clinico-pathological analysis of 172 patients with multiple primary malignant tumors (MPMT) (author's transl)]. , 1979 .

[17]  H. Liedloff,et al.  Multiple primary malignant tumors , 1970 .

[18]  Macdonald Ej.  Occurrence of multiple primary cancers in a population of 200,000. , 1960 .

[19]  E. J. Macdonald.  Occurrence of multiple primary cancers in a population of 200,000. , 1960, Acta - Unio Internationalis Contra Cancrum.

[20]  S. Warren.  Multiple primary malignant tumors. A survey of the literature and a statistical study , 1932 .