Raman Spectroscopy and Fluorescence Photon Migration for Breast Cancer Diagnosis and Imaging

We are developing optical methods based on near infra‐red Raman spectroscopy and fluorescence photon migration for diagnosis and localization of breast cancer. We demonstrate the ability of Raman spectroscopy to classify accurately normal, benign and malignant breast tissues, an important step in developing Raman spectroscopic needle probes as a tool for improving the accuracy of needle biopsy. We also show that photon migration imaging can be used to localize accurately small fluorescent objects imbedded in a thick turbid medium with realistic optical properties, thus demonstrating the potential of this technique for optical imaging.

[1]  M S Feld,et al.  Fluorescence tomographic imaging in turbid media using early-arriving photons and Laplace transforms. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[2]  M S Feld,et al.  Determination of human coronary artery composition by Raman spectroscopy. , 1997, Circulation.

[3]  M S Patterson,et al.  Imaging of fluorescent yield and lifetime from multiply scattered light reemitted from random media. , 1997, Applied optics.

[4]  Yang Wang,et al.  Near-Infrared Raman Spectrometer Systems for Human Tissue Studies , 1997 .

[5]  J. Wu Convolution picture of the boundary conditions in photon migration and its implications in time-resolved optical imaging of biological tissues. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[6]  J L Luke,et al.  Raman chemical imaging: histopathology of inclusions in human breast tissue. , 1996, Analytical chemistry.

[7]  T L Troy,et al.  Optical properties of normal and diseased breast tissues: prognosis for optical mammography. , 1996, Journal of biomedical optics.

[8]  Ramasamy Manoharan,et al.  Histochemical analysis of biological tissues using Raman spectroscopy , 1996 .

[9]  Jun Wu Photon migration in turbid media : time-resolved optical imaging in tissue-like phantom , 1996 .

[10]  N Ramanujam,et al.  Development of a multivariate statistical algorithm to analyze human cervical tissue fluorescence spectra acquired in vivo , 1996, Lasers in surgery and medicine.

[11]  R. Richards-Kortum,et al.  Raman spectroscopy for the detection of cancers and precancers. , 1996, Journal of biomedical optics.

[12]  E. Sevick-Muraca,et al.  Quantitative optical spectroscopy for tissue diagnosis. , 1996, Annual review of physical chemistry.

[13]  Shoko Nioka,et al.  Breast tumor detection using continuous wave light source , 1995, Photonics West.

[14]  B. Chance,et al.  Optical Tomography, Photon Migration, and Spectroscopy of Tissue and Model Media: Theory, Human Studies, and Instrumentation , 1995 .

[15]  J Wu,et al.  Time-resolved multichannel imaging of fluorescent objects embedded in turbid media. , 1995, Optics letters.

[16]  Christopher J. Frank,et al.  Raman spectroscopy of normal and diseased human breast tissues. , 1995, Analytical chemistry.

[17]  E H Holmes,et al.  The etiology and prediction of breast cancer. Fourier transform‐infrared spectroscopy reveals progressive alterations in breast DNA leading to a cancer‐like phenotype in a high proportion of normal women , 1995, Cancer.

[18]  Joerg-Uwe Meyer,et al.  Evaluation of changes in the NADH level between carcinogenic and normal tissue samples by use of fluorescence spectroscopy , 1995, Other Conferences.

[19]  Marchant Dj Contemporary management of breast cancer. , 1994 .

[20]  W. Zinth,et al.  Time-gated transillumination of biological tissues and tissuelike phantoms. , 1994, Applied optics.

[21]  K Svanberg,et al.  Photodynamic therapy of non‐melanoma malignant tumours of the skin using topical δ‐amino levulinic acid sensitization and laser irradiation , 1994, The British journal of dermatology.

[22]  Feld,et al.  Photon migration in turbid media using path integrals. , 1994, Physical review letters.

[23]  T. Gansler,et al.  Characterization of human breast biopsy specimens with near-IR Raman spectroscopy. , 1994, Analytical chemistry.

[24]  Chance,et al.  Scattering and wavelength transduction of diffuse photon density waves. , 1993, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[25]  D A Benaron,et al.  Optical time-of-flight and absorbance imaging of biologic media. , 1993, Science.

[26]  J C Hebden,et al.  Time-resolved optical tomography. , 1993, Applied optics.

[27]  R R Alfano,et al.  Double-stage picosecond Kerr gate for ballistic time-gated optical imaging in turbid media. , 1993, Applied optics.

[28]  O Jarlman,et al.  Medical transillumination imaging using short-pulse diode lasers. , 1993, Applied optics.

[29]  Chance,et al.  Refraction of diffuse photon density waves. , 1992, Physical review letters.

[30]  P. Rabinovitch,et al.  Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele. , 1992, Gastroenterology.

[31]  R. Rava,et al.  Quantitative histochemical analysis of human artery using Raman spectroscopy. , 1992, Journal of photochemistry and photobiology. B, Biology.

[32]  R. Rava,et al.  In situ optical histochemistry of human artery using near infrared Fourier transform Raman spectroscopy. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[33]  R. Alfano,et al.  Human breast tissues studied by IR Fourier-transform Raman spectroscopy , 1991 .

[34]  Britton Chance,et al.  Photon migration in a model of the head measured using time- and frequency-domain techniques: potentials of spectroscopy and imaging , 1991, Photonics West - Lasers and Applications in Science and Engineering.

[35]  G A Losa,et al.  Partial characterization of proteoglycans isolated from neoplastic and nonneoplastic human breast tissues. , 1991, Cancer research.

[36]  K. Pritzker,et al.  Calcium Oxalate Crystals in Breast Biopsies The Missing Microcalcifications , 1990, The American journal of surgical pathology.

[37]  B. Wilson,et al.  Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. , 1989, Applied optics.

[38]  W Lohmann,et al.  Native fluorescence of the cervix uteri as a marker for dysplasia and invasive carcinoma. , 1989, European journal of obstetrics, gynecology, and reproductive biology.

[39]  R. Alfano,et al.  Optical spectroscopic diagnosis of cancer and normal breast tissues , 1989 .

[40]  D. Choy,et al.  Fluorescence spectra from cancerous and normal human breast and lung tissues , 1987, Annual Meeting Optical Society of America.

[41]  Y F Li,et al.  Characteristic autofluorescence for cancer diagnosis and its origin. , 1987, Lasers in surgery and medicine.

[42]  D. Harris,et al.  Endogenous porphyrin fluorescence in tumors , 1987, Lasers in surgery and medicine.

[43]  B. Kowalski,et al.  Partial least-squares regression: a tutorial , 1986 .

[44]  J. Moan,et al.  Tumor-localizing and photosensitizing properties of the main components of hematoporphyrin derivative. , 1984, Cancer research.

[45]  B. Chance,et al.  On the fluorescence of NAD(P)H in whole-cell preparations of tumours and normal tissues. , 1970, European journal of biochemistry.

[46]  M. Laberge [Cancer of the breast]. , 1961, Laval medical.