IL‐17‐producing γδ T cells

IL‐17 is produced not only by CD4+ αβ T cells, but also CD8+ αβ T cells, NKT cells, and γδ T cells, plus some non‐T cells, including macrophages and neutrophils. The ability of IL‐17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, γδ T cells are responsible for much of the IL‐17 produced in several disease models, particularly early on.

[1]  M. Itsumi,et al.  Identification of CD25+ γδ T Cells As Fetal Thymus-Derived Naturally Occurring IL-17 Producers1 , 2008, The Journal of Immunology.

[2]  K. Mills.  Induction, function and regulation of IL‐17‐producing T cells , 2008, European journal of immunology.

[3]  S. Nakae,et al.  IL-17A Produced by γδ T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver1 , 2008, The Journal of Immunology.

[4]  Y. Iwakura,et al.  IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance. , 2008, International immunology.

[5]  K. Nakayama,et al.  Tyk2-Signaling Plays an Important Role in Host Defense against Escherichia coli through IL-23-Induced IL-17 Production by γδ T Cells1 , 2008, The Journal of Immunology.

[6]  M. Kopf,et al.  SCART Scavenger Receptors Identify a Novel Subset of Adult γδ T Cells1 , 2008, The Journal of Immunology.

[7]  Mark M. Davis,et al.  Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gamma. , 2008, Immunity.

[8]  S. Tangye,et al.  Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3 , 2008, The Journal of experimental medicine.

[9]  J. V. Sarma,et al.  Adverse functions of IL‐17A in experimental sepsis , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[10]  V. Kuchroo,et al.  Induction and effector functions of TH17 cells , 2008, Nature.

[11]  W. Born,et al.  gammadelta T cells: an important source of IL-17. , 2008, Current opinion in immunology.

[12]  Jing Wang,et al.  Interleukin 17-Producing γδ T Cells Increased in Patients with Active Pulmonary Tuberculosis , 2008, Cellular and Molecular Immunology.

[13]  Julia M. Lewis,et al.  Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells , 2008, Nature Genetics.

[14]  R. Braun,et al.  IL-17 Producing γδ T Cells are Required for a Controlled Inflammatory Response after Bleomycin-induced Lung Injury , 2008, Inflammation.

[15]  U. Grohmann,et al.  Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease , 2008, Nature.

[16]  A. Bendele,et al.  Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing γδ T Cells1 , 2007, The Journal of Immunology.

[17]  Hisakata Yamada,et al.  Resident Vδ1+ γδ T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production1 , 2007, The Journal of Immunology.

[18]  S. Nakae,et al.  IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guérin Infection1 , 2007, The Journal of Immunology.

[19]  J. Flynn,et al.  IL-17 Production Is Dominated by γδ T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection1 , 2006, The Journal of Immunology.

[20]  I. Douglas,et al.  Regulatory Role of γδ T Cells in the Recruitment of CD4+ and CD8+ T Cells to Lung and Subsequent Pulmonary Fibrosis1 , 2006, The Journal of Immunology.

[21]  D. Littman,et al.  The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells , 2006, Cell.

[22]  K. Ley,et al.  Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. , 2005, Immunity.

[23]  H. Kidoya,et al.  Involvement of IL-17 in Fas ligand-induced inflammation. , 2004, International immunology.

[24]  S. Akira,et al.  Expression of Toll-Like Receptor 2 on γδ T Cells Bearing Invariant Vγ6/Vδ1 Induced by Escherichia coli Infection in Mice1 , 2000, The Journal of Immunology.

[25]  H. Takada,et al.  Escherichia coli infection induces only fetal thymus‐derived γ δ T cells at the infected site , 1999 .

[26]  J. Miyazaki,et al.  Developmentally ordered V-J recombination in mouse T cell receptor gamma locus is not perturbed by targeted deletion of the Vgamma4 gene. , 1997, Journal of immunology.