Recent Microdevice-Based Aptamer Sensors

Since the systematic evolution of ligands by exponential enrichment (SELEX) method was developed, aptamers have made significant contributions as bio-recognition sensors. Microdevice systems allow for low reagent consumption, high-throughput of samples, and disposability. Due to these advantages, there has been an increasing demand to develop microfluidic-based aptasensors for analytical technique applications. This review introduces the principal concepts of aptasensors and then presents some advanced applications of microdevice-based aptasensors on several platforms. Highly sensitive detection techniques, such as electrochemical and optical detection, have been integrated into lab-on-a-chip devices and researchers have moved towards the goal of establishing point-of-care diagnoses for target analyses.

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[61]  Hadi Mirzajani,et al.  A highly sensitive and specific capacitive aptasensor for rapid and label-free trace analysis of Bisphenol A (BPA) in canned foods. , 2017, Biosensors & bioelectronics.

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[65]  Xuexia Lin,et al.  A portable microchip for ultrasensitive and high-throughput assay of thrombin by rolling circle amplification and hemin/G-quadruplex system. , 2014, Biosensors & bioelectronics.

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[67]  Meihua Yang,et al.  An aptamer based lateral flow strip for on-site rapid detection of ochratoxin A in Astragalus membranaceus. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[68]  Jinghua Yu,et al.  A microfluidic origami electrochemiluminescence aptamer-device based on a porous Au-paper electrode and a phenyleneethynylene derivative. , 2013, Chemical communications.

[69]  Jie Deng,et al.  Nanoimprinted thrombin aptasensor with picomolar sensitivity based on plasmon excited quantum dots , 2015 .

[70]  Xuan Weng,et al.  Aptamer-based fluorometric determination of norovirus using a paper-based microfluidic device , 2017, Microchimica Acta.

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[73]  Simon Chi-Chin Shiu,et al.  A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis. , 2018, Biosensors & bioelectronics.

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[75]  Qiao Lin,et al.  Integrated Microfluidic Aptasensor for Mass Spectrometric Detection of Vasopressin in Human Plasma Ultrafiltrate. , 2016, Analytical methods : advancing methods and applications.

[76]  Yan Su,et al.  A Microfluidic Love-Wave Biosensing Device for PSA Detection Based on an Aptamer Beacon Probe , 2015, Sensors.

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[81]  Chia-Chen Chang,et al.  Disposable surface plasmon resonance aptasensor with membrane-based sample handling design for quantitative interferon-gamma detection. , 2014, Lab on a chip.

[82]  Ailiang Chen,et al.  Replacing antibodies with aptamers in lateral flow immunoassay. , 2015, Biosensors & bioelectronics.

[83]  Gwo-Bin Lee,et al.  An integrated microfluidic system for measurement of glycated hemoglobin levels by using an aptamer-antibody assay on magnetic beads. , 2015, Biosensors & bioelectronics.

[84]  Xuewen Lu,et al.  A sensitive lateral flow biosensor for Escherichia coli O157:H7 detection based on aptamer mediated strand displacement amplification. , 2015, Analytica chimica acta.

[85]  H. Ho,et al.  An Assay Using Localized Surface Plasmon Resonance and Gold Nanorods Functionalized with Aptamers to Sense the Cytochrome-c Released from Apoptotic Cancer Cells for Anti-Cancer Drug Effect Determination , 2017, Micromachines.

[86]  Gwo-Bin Lee,et al.  Influenza A virus-specific aptamers screened by using an integrated microfluidic system. , 2014, Lab on a chip.

[87]  Gwo-Bin Lee,et al.  On-chip, aptamer-based sandwich assay for detection of glycated hemoglobins via magnetic beads. , 2016, Biosensors & bioelectronics.

[88]  Han Wei Hou,et al.  Identification of malaria parasite-infected red blood cell surface aptamers by inertial microfluidic SELEX (I-SELEX) , 2015, Scientific Reports.

[89]  Yi Liu,et al.  Enhanced and Differential Capture of Circulating Tumor Cells from Lung Cancer Patients by Microfluidic Assays Using Aptamer Cocktail. , 2016, Small.

[90]  Rijun Gui,et al.  Facilely self-assembled magnetic nanoparticles/aptamer/carbon dots nanocomposites for highly sensitive up-conversion fluorescence turn-on detection of tetrodotoxin. , 2018, Talanta.

[91]  Yi Lu,et al.  Aptamer-based origami paper analytical device for electrochemical detection of adenosine. , 2012, Angewandte Chemie.

[92]  Suresh Neethirajan,et al.  Microfluidic platform integrated with graphene-gold nano-composite aptasensor for one-step detection of norovirus. , 2017, Biosensors & bioelectronics.

[93]  Ming Zhou,et al.  Microfluidic electrochemical aptameric assay integrated on-chip: a potentially convenient sensing platform for the amplified and multiplex analysis of small molecules. , 2011, Analytical chemistry.

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[96]  Yanbin Li,et al.  An Impedance Aptasensor with Microfluidic Chips for Specific Detection of H5N1 Avian Influenza Virus , 2015, Sensors.

[97]  Takashi Yoneda,et al.  PEP-on-DEP: A competitive peptide-based disposable electrochemical aptasensor for renin diagnostics. , 2016, Biosensors & bioelectronics.

[98]  Qian Wang,et al.  Highly sensitive and homogeneous detection of membrane protein on a single living cell by aptamer and nicking enzyme assisted signal amplification based on microfluidic droplets. , 2014, Analytical chemistry.

[99]  Mao Ye,et al.  Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases , 2017, Journal of Molecular Medicine.

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[101]  Xuan Weng,et al.  Paper‐based microfluidic aptasensor for food safety , 2018 .

[102]  Weihong Tan,et al.  Multivalent DNA nanospheres for enhanced capture of cancer cells in microfluidic devices. , 2013, ACS nano.

[103]  Claudio Piemonte,et al.  SPAD aptasensor for the detection of circulating protein biomarkers. , 2015, Biosensors & bioelectronics.

[104]  Suresh Neethirajan,et al.  Detection of protein kinase using an aptamer on a microchip integrated electrolyte-insulator-semiconductor sensor , 2017 .

[105]  H. Hibino,et al.  On-chip graphene oxide aptasensor for multiple protein detection. , 2015, Analytica chimica acta.

[106]  Homayoun Najjaran,et al.  Microfluidics Integrated Biosensors: A Leading Technology towards Lab-on-a-Chip and Sensing Applications , 2015, Sensors.