In Situ Osteogenesis of Hemimandible With rhBMP-2 in a 9-Year-Old Boy: Osteoinduction Via Stem Cell Concentration

J uvenile active ossifying fibroma (JAOF) is a benign fibro-osseous lesion with a tendency to occur in children and adolescents. Its clinical behavior is notable for locally aggressive growth within the craniofacial bones and a significant recurrence rate, varying between 30% and 58%. Although this is a rare lesion, it can result in significant facial distortion in a young patient. Controversy exists regarding the treatment of JAOF. There are proponents for both enucleation and complete resection. When a tumor reaches a size that mandates resection of the involved bone, the focus should be on achieving the best functional and aesthetic reconstruction for the child. The authors present a case of recurrent, locally aggressive tumor requiring hemimandibulectomy and a new technique for mandible reconstruction involving in situ osteogenesis with recombinant bone morphogenetic protein (rhBMP-2).

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