论文信息 - MONO‐OLIGOCLONAL PRODUCTION OF IMMUNOGLOBULINS IN A CHILD WITH THE WISKOTT‐ALDRICH SYNDROME

MONO‐OLIGOCLONAL PRODUCTION OF IMMUNOGLOBULINS IN A CHILD WITH THE WISKOTT‐ALDRICH SYNDROME

We describe a patient with WAS, who developed severe haemorrhagic eczema and thrombocytopenia at the age of 6 months. He also suffered from multiple episodes of otitis and brochitis. At the age of 4.5 years, a splenectomy was performed and two enlarged hilar lymph nodes composed of monoclonal λ-positive B lymphocytes were found

J. Tissot | P. Schneider | P. Frei | B. Pelet | Denis Hochstrasser

[1] R. Kyle,et al. Two-dimensional gel electrophoresis as an aid in the analysis of monoclonal gammopathies. , 1984, Human pathology.

[2] Jean-Daniel Tissot,et al. Etude par électrophorèse bidimensionnelle de gammapathies monoclonales et d'agglutinines froides associées à une anémie hémolytique chronique , 1989 .

[3] D F Hochstrasser,et al. Methods for increasing the resolution of two-dimensional protein electrophoresis. , 1988, Analytical biochemistry.

[4] F. Rosen,et al. The primary immunodeficiencies: first of two parts , 1984 .

[5] J. Radl,et al. Immunoglobulins and transient paraproteins in sera of patients with the Wiskott-Aldrich syndrome: a follow-up study. , 1976, Clinical and experimental immunology.

[6] R. Blaese,et al. Monoclonal gammopathy in the Wiskott-Aldrich syndrome. , 1974, The Journal of pediatrics.

[7] G. Mariani,et al. Inhibitor to factor VIII in a non-haemophilic patient: evaluation of the response to DDAVP and the in vitro kinetics of factor VIII. A case report. , 1987, Nouvelle revue francaise d'hematologie.

[8] N. Anderson,et al. 4 – High-Resolution Two-Dimensional Electrophoretic Mapping of Plasma Proteins , 1984 .