论文信息 - Cancer regression by senescence.

Cancer regression by senescence.

Experiments in mouse models of lymphoma, sarcoma, and hepatocarcinoma indicate that targeting p53 may be a sensible therapeutic strategy and that cellular senescence contributes to tumor regression.

M. Serrano

[1] T. Jacks,et al. Restoration of p53 function leads to tumour regression in vivo , 2007, Nature.

[2] M. Serrano,et al. The power and the promise of oncogene-induced senescence markers , 2006, Nature Reviews Cancer.

[3] Carlos Cordon-Cardo,et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas , 2007, Nature.

[4] Gerard I. Evan,et al. Modeling the Therapeutic Efficacy of p53 Restoration in Tumors , 2006, Cell.