Combined use of native and caged mussels to assess biological effects of pollution through the integrative biomarker approach.

[1]  Larraitz Garmendia,et al.  Cell and tissue biomarkers in mussel, and histopathology in hake and anchovy from Bay of Biscay after the Prestige oil spill (Monitoring Campaign 2003). , 2006, Marine pollution bulletin.

[2]  J. Namieśnik,et al.  Concentration of bioactive compounds in mussels Mytilus galloprovincialis as an indicator of pollution. , 2008, Chemosphere.

[3]  A. Usobiaga,et al.  Simultaneous microwave-assisted extraction of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, phthalate esters and nonylphenols in sediments. , 2005, Journal of chromatography. A.

[4]  P. Garrigues,et al.  Polycyclic aromatic hydrocarbons in recent sediments and mussels (Mytilus edulis) from the Western Baltic Sea: occurrence, bioavailability and seasonal variations , 1999 .

[5]  I. Cancio,et al.  Seasonal variation of peroxisomal enzyme activities and peroxisomal structure in mussels Mytilus galloprovincialis and its relationship with the lipid content. , 1999, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

[6]  Herman Hummel,et al.  Response of the blue mussel Mytilus edulis L. following exposure to PAHs or contaminated sediment , 1995 .

[7]  U. Izagirre,et al.  Lysosomal enlargement and lysosomal membrane destabilisation in mussel digestive cells measured by an integrative index. , 2009, Environmental pollution.

[8]  I. Cancio,et al.  Reversible alterations in epithelial cell turnover in digestive gland of winkles (Littorina littorea) exposed to cadmium and their implications for biomarker measurements. , 2007, Aquatic toxicology.

[9]  C. Nasci,et al.  Field application of lysosomal destabilisation indices in the mussel Mytilus galloprovincialis: biomonitoring and transplantation in the Lagoon of Venice (north-east Italy). , 2002, Marine environmental research.

[10]  S. Dailianis,et al.  Evaluation of neutral red retention assay, micronucleus test, acetylcholinesterase activity and a signal transduction molecule (cAMP) in tissues of Mytilus galloprovincialis (L.), in pollution monitoring. , 2003, Marine environmental research.

[11]  M. Pacheco,et al.  Glutathione protects heavy metal-induced inhibition of hepatic microsomal ethoxyresorufin O-deethylase activity in Dicentrarchus labrax L. , 2004, Ecotoxicology and environmental safety.

[12]  M. Connock,et al.  A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase. , 1985, The Biochemical journal.

[13]  Larraitz Garmendia,et al.  Marine ecosystem health status assessment through integrative biomarker indices: a comparative study after the Prestige oil spill “Mussel Watch” , 2013, Ecotoxicology.

[14]  C. Georgiou,et al.  Translational responses of Mytilus galloprovincialis to environmental pollution: integrating the responses to oxidative stress and other biomarker responses into a general stress index. , 2008, Aquatic toxicology.

[15]  Á. Borja,et al.  Preface (to: Oceanography and marine environment of the Basque Country) , 2004 .

[16]  J. Lazutka,et al.  Analysis of micronuclei in blue mussels and fish from the Baltic and North Seas , 2004, Environmental toxicology.

[17]  M. Ortiz-Zarragoitia,et al.  Biomarkers of Exposure and Reproduction-Related Effects in Mussels Exposed to Endocrine Disruptors , 2006, Archives of environmental contamination and toxicology.

[18]  M. Marin,et al.  Effects of 4-nonylphenol exposure in mussels (Mytilus galloprovincialis) and crabs (Carcinus aestuarii) with particular emphasis on vitellogenin induction. , 2008, Marine pollution bulletin.

[19]  P. Venier,et al.  Susceptibility to genetic damage and cell types in Mediterranean mussels. , 2002, Marine environmental research.

[20]  F. Regoli,et al.  Cellular biomarkers for monitoring estuarine environments: transplanted versus native mussels. , 2006, Aquatic toxicology.

[21]  P. Molíst,et al.  PARTICULAR ASPECTS OF GONADAL CYCLE AND SEASONAL DISTRIBUTION OF GAMETOGENIC STAGES OF MYTILUS GALLOPROVINCIALIS CULTURED IN THE ESTUARY OF VIGO , 2009 .

[22]  R. Green,et al.  Oxidative damage in gill of Mytilus edulis from Merseyside, UK, and reversibility after depuration. , 2008, Environmental pollution.

[23]  S. Canova,et al.  Detection of micronuclei in gill cells and haemocytes of mussels exposed to benzo[a]pyrene. , 1997, Mutation research.

[24]  P. Harris,et al.  Survival in air of Mytilus trossulus following long-term exposure to spilled Exxon Valdez crude oil in Prince William Sound. , 1999, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

[25]  E. Papathanassiou,et al.  Application of two SH-based methods for metallothionein determination in mussels and intercalibration of the spectrophotometric method: laboratory and field studies in the Mediterranean Sea , 2005, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[26]  V. Dimitriadis,et al.  Multiple Biomarker Comparison in Mytilus galloprovincialis from the Greece Coast: “Lysosomal Membrane Stability, Neutral Red Retention, Micronucleus Frequency and Stress on Stress” , 2005, Ecotoxicology.

[27]  A. Sureda,et al.  Biochemical responses of Mytilus galloprovincialis as biomarkers of acute environmental pollution caused by the Don Pedro oil spill (Eivissa Island, Spain). , 2011, Aquatic toxicology.

[28]  M. Ortiz-Zarragoitia,et al.  Interactive effects of benzo(a)pyrene and cadmium and effects of di(2-ethylhexyl) phthalate on antioxidant and peroxisomal enzymes and peroxisomal volume density in the digestive gland of mussel Mytilus galloprovincialis Lmk , 2002, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[29]  J. Albaigés,et al.  Bioaccumulation patterns of hydrocarbons and polychlorinated biphenyls in bivalves, crustaceans, and fishes , 1994, Archives of environmental contamination and toxicology.

[30]  M. Soto,et al.  Metal bioavailability assessment in \'mussel-watch\' programmes by automated image analysis of autometallographical black silver deposits (BSD) in digestive cell lysosomes , 1997 .

[31]  R. Seed The ecology of Mytilus edulis L. (Lamellibranchiata) on exposed rocky shores , 1969, Oecologia.

[32]  J. Pedrajas,et al.  Oxidative stress in fish exposed to model xenobiotics. Oxidatively modified forms of Cu,Zn-superoxide dismutase as potential biomarkers. , 1995, Chemico-biological interactions.

[33]  U. Izagirre,et al.  Application of a battery of biomarkers in mussel digestive gland to assess long-term effects of the Prestige oil spill in Galicia and the Bay of Biscay: lysosomal responses. , 2011, Journal of environmental monitoring : JEM.

[34]  E. Angulo,et al.  Cellular and subcellular distribution of metals in molluscs , 2002, Microscopy research and technique.

[35]  A. Viarengo,et al.  A simple spectrophotometric method for metallothionein evaluation in marine organisms: an application to Mediterranean and Antarctic molluscs , 1997 .

[36]  F. Gagné,et al.  Evaluation of estrogenic effects of municipal effluents to the freshwater mussel Elliptio complanata. , 2001, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[37]  C. Hunt,et al.  Long-term monitoring using resident and caged mussels in Boston Harbor yield similar spatial and temporal trends in chemical contamination. , 2010, Marine environmental research.

[38]  P. Garrigues,et al.  One-year monitoring survey of organic compounds (PAHs, PCBs, TBT), heavy metals and biomarkers in blue mussels from the Arcachon Bay, France. , 2005, Journal of environmental monitoring : JEM.

[39]  E. Angulo,et al.  Histopathology of the digestive gland-gonad complex of the marine prosobranch Littorina littorea exposed to cadmium , 1990 .

[40]  I. Muxika,et al.  Assessing reference conditions and physico-chemical status according to the European Water Framework Directive: a case-study from the Basque Country (Northern Spain). , 2005, Marine pollution bulletin.

[41]  M. Soto,et al.  Changes in mussel biometry on exposure to metals: implications in estimation of metal bioavailability in 'Mussel-Watch' programmes. , 2000, The Science of the total environment.

[42]  A. Riveros,et al.  Cellular Biomarkers in Native and Transplanted Populations of the Mussel Perumytilus purpuratus in the Intertidal Zones of San Jorge Bay, Antofagasta, Chile , 2002, Archives of Environmental Contamination and Toxicology.

[43]  M. Grung,et al.  PAH body burden and biomarker responses in mussels (Mytilus edulis) exposed to produced water from a North Sea oil field: laboratory and field assessments. , 2011, Marine pollution bulletin.

[44]  C Minier,et al.  Seasonal variations of a battery of biomarkers and physiological indices for the mussel Mytilus galloprovincialis transplanted into the northwest Mediterranean Sea. , 2004, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[45]  M. Moore Cytochemical responses of the lysosomal system and NADPH-ferrihemoprotein reductase in molluscan digestive cells to environmental and experimental exposure to xenobiotics , 1988 .

[46]  J. Allen,et al.  Environmental prognostics: an integrated model supporting lysosomal stress responses as predictive biomarkers of animal health status. , 2006, Marine environmental research.

[47]  J. R. Payne,et al.  Long term monitoring for oil in the Exxon Valdez spill region. , 2008, Marine pollution bulletin.

[48]  F. Regoli Lysosomal responses as a sensitive stress index in biomonitoring heavy metal pollution , 1992 .

[49]  E. L. Avery,et al.  The detection of pollutant impact in marine environments: Condition index, oxidative DNA damage, and their associations with metal bioaccumulation in the Sydney rock oyster Saccostrea commercialis , 1996, Archives of environmental contamination and toxicology.

[50]  G. Arana,et al.  Comparison of solid phase extraction, saponification and gel permeation chromatography for the clean-up of microwave-assisted biological extracts in the analysis of polycyclic aromatic hydrocarbons. , 2006, Journal of chromatography. A.

[51]  J. Hellou,et al.  Stress on stress response of wild mussels, Mytilus edulis and Mytilus trossulus, as an indicator of ecosystem health. , 2003, Environmental pollution.

[52]  I. Cancio,et al.  Subcellular Distribution of Cadmium and its Cellular Ligands in Mussel Digestive Gland Cells as Revealed by Combined Autometallography and X-ray Microprobe Analysis , 2002, The Histochemical Journal.

[53]  D. Fattorini,et al.  Contaminant accumulation and biomarker responses in caged mussels, Mytilus galloprovincialis, to evaluate bioavailability and toxicological effects of remobilized chemicals during dredging and disposal operations in harbour areas. , 2008, Aquatic toxicology.

[54]  A. Viarengo,et al.  A Biomonitoring Study Assessing the Residual Biological Effects of Pollution Caused by the HAVEN Wreck on Marine Organisms in the Ligurian Sea (Italy) , 2007, Archives of environmental contamination and toxicology.

[55]  M. Bebianno,et al.  A multi-biomarker approach in cross-transplanted mussels Mytilus galloprovincialis , 2011, Ecotoxicology.

[56]  M. Soto,et al.  Seasonality in cell and tissue-level biomarkers in Mytilus galloprovincialis: relevance for long-term pollution monitoring , 2010 .

[57]  Usha Varanasi,et al.  Effect of environmental contaminants on the health of Mytilus edulis from Puget Sound, Washington, USA. I. Cytochemical measures of lysosomal responses in the digestive cells using automatic image analysis , 1994 .

[58]  F. Gagné,et al.  Sex alteration in soft-shell clams (Mya arenaria) in an intertidal zone of the Saint Lawrence river (Quebec, Canada). , 2003, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[59]  F. Galgani,et al.  Multiple biomarkers of pollution effects in caged mussels on the Greek coastline. , 2010, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[60]  Claudia Bolognesi,et al.  Genotoxicity biomarkers in M. galloprovincialis as indicators of marine pollutants , 1996 .

[61]  S. Arrasate,et al.  Distribution and bioaccumulation of PAHs in the UNESCO protected natural reserve of Urdaibai, Bay of Biscay. , 2008, Chemosphere.

[62]  G. Fabi,et al.  Integrated use of biomarkers in the mussel Mytilus galloprovincialis for assessing off-shore gas platforms in the Adriatic Sea: results of a two-year biomonitoring program. , 2011, Marine pollution bulletin.

[63]  M. P. Ireland,et al.  The contribution of metal/shell-weight index in target-tissues to metal body burden in sentinel marine molluscs. 2. Mytilus galloprovincialis , 1997 .

[64]  Katja Broeg,et al.  Indices for the assessment of environmental pollution of the Baltic Sea coasts: integrated assessment of a multi-biomarker approach. , 2006, Marine pollution bulletin.

[65]  S. Salazar,et al.  Using caged bivalves to characterize exposure and effects associated with pulp and paper mill effluents , 1997 .

[66]  I. Cancio,et al.  Tissue- and cell-specific expression of metallothionein genes in cadmium- and copper-exposed mussels analyzed by in situ hybridization and RT-PCR. , 2007, Toxicology and applied pharmacology.

[67]  S. Romano,et al.  Bioaccumulation and biomarker responses of trace metals and micro-organic pollutants in mussels and fish from the Lagoon of Venice, Italy. , 2007, Marine pollution bulletin.

[68]  A. Smaal,et al.  Response to stress of mussels (Mytilus edulis) exposed in Dutch tidal waters. , 1991, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

[69]  A Doyotte,et al.  Antioxidant enzymes, glutathione and lipid peroxidation as relevant biomarkers of experimental or field exposure in the gills and the digestive gland of the freshwater bivalve Unio tumidus , 1997 .

[70]  M. Soto,et al.  Application of a battery of biomarkers in mussel digestive gland to assess long-term effects of the Prestige oil spill in Galicia and Bay of Biscay: tissue-level biomarkers and histopathology. , 2011, Journal of environmental monitoring : JEM.

[71]  R. Macdonald,et al.  PAHs in the Fraser River basin: a critical appraisal of PAH ratios as indicators of PAH source and composition , 2002 .

[72]  P. Frickers,et al.  Integration of biochemical, histochemical and toxicogenomic indices for the assessment of health status of mussels from the Tamar Estuary, U.K. , 2011, Marine environmental research.

[73]  A Viarengo,et al.  Development of an expert system for the integration of biomarker responses in mussels into an animal health index , 2007, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[74]  R. Brunetti,et al.  The micronucleus test: temporal pattern of baseline frequency in Mytilus galloprovincialis , 1992 .

[75]  D. Pampanin,et al.  Physiological measurements from native and transplanted mussel (Mytilus galloprovincialis) in the canals of Venice. Survival in air and condition index. , 2005, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[76]  S. Brooks,et al.  Integrated biomarker assessment of the effects exerted by treated produced water from an onshore natural gas processing plant in the North Sea on the mussel Mytilus edulis. , 2011, Marine pollution bulletin.

[77]  I. Cancio,et al.  Cell biology of peroxisomes and their characteristics in aquatic organisms. , 2000, International review of cytology.

[78]  R. Ramos,et al.  Natural variability in size and membrane stability of lysosomes in mussel digestive cells: seasonal and tidal zonation , 2008 .

[79]  F. Galgani,et al.  Monitoring chemical contamination levels in the Mediterranean based on the use of mussel caging. , 2004, Marine pollution bulletin.

[80]  A. Geffard,et al.  Metallothionein concentration in the mussel Mytilus galloprovincialis as a biomarker of response to metal contamination: validation in the field , 2002, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[81]  A Viarengo,et al.  The use of biomarkers to assess the impact of pollution in coastal environments of the Iberian Peninsula: a practical approach. , 2000, The Science of the total environment.

[82]  M. Ortiz-Zarragoitia,et al.  Application of a battery of biomarkers in mussel digestive gland to assess long-term effects of the Prestige oil spill in Galicia and Bay of Biscay: correlation and multivariate analysis. , 2011, Journal of environmental monitoring : JEM.

[83]  Ketil Hylland,et al.  Contaminants in marine ecosystems: developing an integrated indicator framework using biological-effect techniques , 2008 .

[84]  M Babut,et al.  Glutathione reductase, selenium-dependent glutathione peroxidase, glutathione levels, and lipid peroxidation in freshwater bivalves, Unio tumidus, as biomarkers of aquatic contamination in field studies. , 1997, Ecotoxicology and environmental safety.

[85]  S. Leiniö,et al.  Biomarkers of pollution effects in the bivalves Mytilus edulis and Macoma balthica collected from the southern coast of Finland (Baltic Sea) , 2006 .

[86]  M. Soto,et al.  BSD extent, an index for metal pollution screening based on the metal content within digestive cell lysosomes of mussels as determined by autometallography. , 1997, Ecotoxicology and environmental safety.

[87]  I. Cancio,et al.  Peroxisome proliferation as a biomarker in environmental pollution assessment , 2003, Microscopy research and technique.

[88]  M. Ortiz-Zarragoitia,et al.  Intersex and oocyte atresia in a mussel population from the Biosphere's Reserve of Urdaibai (Bay of Biscay). , 2010, Ecotoxicology and environmental safety.

[89]  D. Lowe,et al.  Hydrocarbon exposure in mussels: A quantitative study of the responses in the reproductive and nutrient storage cell systems , 1986 .

[90]  F. Galgani,et al.  Evaluation of the micronucleus test on Mytilus galloprovincialis for monitoring applications along french coasts , 1996 .

[91]  F. Valerio,et al.  Polycyclic aromatic hydrocarbon pollution in native and caged mussels. , 2001, Marine pollution bulletin.

[92]  E. Angulo,et al.  responses of basophilic cells of the digestive gland of mussels to petroleum hydrocarbon exposure , 1990 .

[93]  C. Pretti,et al.  Interactions between metabolism of trace metals and xenobiotic agonists of the aryl hydrocarbon receptor in the antarctic fish Trematomus bernacchii: Environmental perspectives , 2005, Environmental toxicology and chemistry.

[94]  I. Marigómez,et al.  Comparison of cytochemical procedures to estimate lysosomal biomarkers in mussel digestive cells. , 2005, Aquatic toxicology.

[95]  D. Fattorini,et al.  An ecotoxicological protocol with caged mussels, Mytilus galloprovincialis, for monitoring the impact of an offshore platform in the Adriatic Sea. , 2008, Marine environmental research.

[96]  M. Ortiz-Zarragoitia,et al.  Biomarkers in mussels from a copper site gradient (Visnes, Norway): an integrated biochemical, histochemical and histological study. , 2006, Aquatic toxicology.

[97]  P. Donkin,et al.  Seasonal variation in cytochrome P450 immunopositive protein levels, lipid peroxidation and genetic toxicity in digestive gland of the mussel Mytilus edulis. , 2004, Aquatic toxicology.

[98]  C. Bolognesi,et al.  DNA damage in eelpout (Zoarces viviparus) from Göteborg harbour. , 2004, Mutation research.

[99]  Evaluation of 4-nonylphenol toxicity in the clam Tapes philippinarum. , 2003, Environmental research.

[100]  R. Seed The ecology of Mytilus edulis L. (Lamellibranchiata) on exposed rocky shores , 1969, Oecologia.

[101]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[102]  M. Cajaraville,et al.  Peroxisome proliferation and antioxidant enzymes in transplanted mussels of four basque estuaries with different levels of polycyclic aromatic hydrocarbon and polychlorinated biphenyl pollution , 2006, Environmental toxicology and chemistry.

[103]  I. Cancio,et al.  Chapter 14 – Biomonitoring of environmental pollution along the Basque coast, using molecular, cellular and tissue-level biomarkers: an integrative approach , 2004 .

[104]  M. Soto,et al.  Autometallographical Procedure for the Localization of Metal Traces in Molluscan Tissues by Light Microscopy , 1998 .

[105]  D. Fattorini,et al.  Time-course variations of oxyradical metabolism, DNA integrity and lysosomal stability in mussels, Mytilus galloprovincialis, during a field translocation experiment. , 2004, Aquatic toxicology.

[106]  S. Rice,et al.  Lack of physiological responses to hydrocarbon accumulation by Mytilus trossulus after 3-4 years chronic exposure to spilled Exxon Valdez crude oil in Prince William Sound. , 1999, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

[107]  A. Viarengo,et al.  Application of a biomarker battery for the evaluation of the sublethal effects of pollutants in the earthworm Eisenia andrei. , 2007, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[108]  A. Usobiaga,et al.  Distribution of Organic Microcontaminants, Butyltins, and Metals in Mussels From the Estuary of Bilbao , 2010, Archives of environmental contamination and toxicology.

[109]  A. Viarengo,et al.  The use of biomarkers in biomonitoring: a 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms. , 2007, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[110]  V. Dimitriadis,et al.  Assessment of the health status of mussels Mytilus galloprovincialis along Thermaikos Gulf (Northern Greece): an integrative biomarker approach using ecosystem health indices. , 2010, Ecotoxicology and environmental safety.

[111]  K. R. Clarke,et al.  Contaminant-induced changes in the structure of the digestive epithelium of Mytilus edulis , 1989 .

[112]  D. Zandee,et al.  Anoxic survival time and metabolic parameters as stress indices in sea mussels exposed to cadmium or polychlorinated biphenyls , 1991 .

[113]  M. Roméo,et al.  Integrated biomarker response index as a useful tool for environmental assessment evaluated using transplanted mussels. , 2007, Chemosphere.

[114]  M. Soto,et al.  Bioavailable heavy metals in estuarine waters as assessed by metal/shell-weight indices in sentinel mussels Mytilus galloprovincialis , 1995 .

[115]  Thierry Burgeot,et al.  Integrated biomarker response: A useful tool for ecological risk assessment , 2002, Environmental toxicology and chemistry.

[116]  G. Janer,et al.  Endocrine disruptors in marine organisms: approaches and perspectives. , 2006, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[117]  E. Giarratano,et al.  Biomarkers and heavy metal bioaccumulation in mussels transplanted to coastal waters of the Beagle Channel. , 2010, Ecotoxicology and environmental safety.

[118]  Malcolm B. Jones,et al.  Application of biomarkers for improving risk assessments of chemicals under the Water Framework Directive: a case study. , 2008, Marine pollution bulletin.

[119]  J. Rank,et al.  DNA damage, acetylcholinesterase activity and lysosomal stability in native and transplanted mussels (Mytilus edulis) in areas close to coastal chemical dumping sites in Denmark. , 2007, Aquatic toxicology.

[120]  J. Bellas,et al.  Integrated use of antioxidant enzymes in mussels, Mytilus galloprovincialis, for monitoring pollution in highly productive coastal areas of Galicia (NW Spain). , 2010, Chemosphere.

[121]  I. Cancio,et al.  Assessment of biological effects of environmental pollution along the NW Mediterranean Sea using mussels as sentinel organisms. , 2007, Environmental pollution.

[122]  P. Francour,et al.  An ecotoxicological approach with transplanted mussels (Mytilus galloprovincialis) for assessing the impact of tyre reefs immersed along the NW Mediterranean Sea. , 2010, Marine environmental research.

[123]  I. Marigómez,et al.  Use of polyclonal antibodies for the detection of changes induced by cadmium in lysosomes of aquatic organisms. , 2000, The Science of the total environment.

[124]  A. Pruski,et al.  Marine invertebrate eco-genotoxicology: a methodological overview. , 2002, Mutagenesis.

[125]  M. Ortiz-Zarragoitia,et al.  Specificity of the peroxisome proliferation response in mussels exposed to environmental pollutants. , 2006, Aquatic toxicology.

[126]  M. Erk,et al.  Is the digestive gland of Mytilus galloprovincialis a tissue of choice for estimating cadmium exposure by means of metallothioneins? , 2004, The Science of the total environment.

[127]  Christian Blaise,et al.  Vitellogenin as a biomarker of exposure to estrogenic compounds in aquatic invertebrates: a review. , 2008, Environment international.

[128]  C. Bolognesi,et al.  Genotoxicity biomarkers in Mytilus galloprovincialis: wild versus caged mussels. , 2004, Mutation research.

[129]  A. Sureda,et al.  Assessment of environmental pollution at Balearic Islands applying oxidative stress biomarkers in the mussel Mytilus galloprovincialis. , 2007, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[130]  M. Ortiz-Zarragoitia,et al.  Effects of the fuel oil spilled by the Prestige tanker on reproduction parameters of wild mussel populations. , 2011, Journal of environmental monitoring : JEM.

[131]  A. Viarengo,et al.  Stress on stress response: A simple monitoring tool in the assessment of a general stress syndrome in mussels , 1995 .

[132]  Valery E Forbes,et al.  The use and misuse of biomarkers in ecotoxicology , 2006, Environmental toxicology and chemistry.

[133]  A. Cearreta,et al.  Recent Anthropogenic Impacts on the Bilbao Estuary, Northern Spain: Geochemical and Microfaunal Evidence , 2000 .

[134]  P. Shin,et al.  Induction, adaptation and recovery of biological responses: implications for environmental monitoring. , 2005, Marine pollution bulletin.

[135]  I. Marigómez,et al.  Pollutant-specific and general lysosomal responses in digestive cells of mussels exposed to model organic chemicals. , 2003, Aquatic toxicology.

[136]  I. Marigómez,et al.  Effects of the Prestige oil spill on cellular biomarkers in intertidal mussels: results of the first year of studies , 2006 .

[137]  D. Lowe Alterations In Cellular Structure Of Mytilus-Edulis Resulting From Exposure To Environmental Contaminants Under Field And Experimental Conditions , 1988 .

[138]  P. Garrigues,et al.  Polycyclic aromatic hydrocarbons in sediments and mussels of the western Mediterranean sea , 1998 .