A Simple Genetic Architecture Underlies Morphological Variation in Dogs

The largest genetic study to date of morphology in domestic dogs identifies genes controlling nearly 100 morphological traits and identifies important trends in phenotypic variation within this species.

[1]  Jeremiah D. Degenhardt,et al.  Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication , 2010, Nature.

[2]  K. Lindblad-Toh,et al.  Localization of Canine Brachycephaly Using an Across Breed Mapping Approach , 2010, PloS one.

[3]  Thomas J. Nicholas,et al.  Tracking footprints of artificial selection in the dog genome , 2010, Proceedings of the National Academy of Sciences.

[4]  Ying Wang,et al.  Genomewide association study of leprosy. , 2009, The New England journal of medicine.

[5]  Judy H. Cho,et al.  Finding the missing heritability of complex diseases , 2009, Nature.

[6]  Catherine André,et al.  Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes , 2009, Science.

[7]  E. H. Margulies,et al.  An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs , 2009, Science.

[8]  Jeremiah D. Degenhardt,et al.  Complex population structure in African village dogs and its implications for inferring dog domestication history , 2009, Proceedings of the National Academy of Sciences.

[9]  Peter J. Bradbury,et al.  The Genetic Architecture of Maize Flowering Time , 2009, Science.

[10]  Joseph K. Pickrell,et al.  The Role of Geography in Human Adaptation , 2009, PLoS genetics.

[11]  John Novembre,et al.  Global distribution of genomic diversity underscores rich complex history of continental human populations. , 2009, Genome research.

[12]  Jonathan Flint,et al.  Genetic architecture of quantitative traits in mice, flies, and humans. , 2009, Genome research.

[13]  Kirk E Lohmueller,et al.  Methods for Human Demographic Inference Using Haplotype Patterns From Genomewide Single-Nucleotide Polymorphism Data , 2009, Genetics.

[14]  A. Boyko,et al.  Linkage Disequilibrium and Demographic History of Wild and Domestic Canids , 2009, Genetics.

[15]  E. Ostrander,et al.  Morphometrics within dog breeds are highly reproducible and dispute Rensch’s rule , 2008, Mammalian Genome.

[16]  K. Lindblad-Toh,et al.  A Mutation in Hairless Dogs Implicates FOXI3 in Ectodermal Development , 2008, Science.

[17]  E. Ostrander,et al.  Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes , 2008, Genetics.

[18]  Peter M Visscher,et al.  Sizing up human height variation , 2008, Nature Genetics.

[19]  D. Heckerman,et al.  Efficient Control of Population Structure in Model Organism Association Mapping , 2008, Genetics.

[20]  G. Barsh,et al.  A β-Defensin Mutation Causes Black Coat Color in Domestic Dogs , 2007, Science.

[21]  K. Lindblad-Toh,et al.  Efficient mapping of mendelian traits in dogs through genome-wide association , 2007, Nature Genetics.

[22]  K. Lindblad-Toh,et al.  Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs , 2007, Nature Genetics.

[23]  E. Ostrander,et al.  Lessons learned from the dog genome. , 2007, Trends in genetics : TIG.

[24]  E. Kirkness,et al.  Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds. , 2007, Genome research.

[25]  Richa Saxena,et al.  A common variant of HMGA2 is associated with adult and childhood height in the general population , 2007, Nature Genetics.

[26]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[27]  C. Bustamante,et al.  A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs , 2007, Science.

[28]  Keyan Zhao,et al.  An Arabidopsis Example of Association Mapping in Structured Samples , 2006, PLoS genetics.

[29]  D. Reich,et al.  Population Structure and Eigenanalysis , 2006, PLoS genetics.

[30]  D. Conrad,et al.  A worldwide survey of haplotype variation and linkage disequilibrium in the human genome , 2006, Nature Genetics.

[31]  N. Sutter,et al.  Genetic architecture of the dog: sexual size dimorphism and functional morphology. , 2006, Trends in genetics : TIG.

[32]  Paul Scheet,et al.  A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. , 2006, American journal of human genetics.

[33]  M. McMullen,et al.  A unified mixed-model method for association mapping that accounts for multiple levels of relatedness , 2006, Nature Genetics.

[34]  G. F. Wagner,et al.  Human stanniocalcin-2 exhibits potent growth-suppressive properties in transgenic mice independently of growth hormone and IGFs. , 2005, American journal of physiology. Endocrinology and metabolism.

[35]  E. Kirkness,et al.  Extensive and breed-specific linkage disequilibrium in Canis familiaris. , 2004, Genome research.

[36]  G. Barsh,et al.  Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs , 2004, Mammalian Genome.

[37]  D. Schluter,et al.  The Genetic Architecture of Parallel Armor Plate Reduction in Threespine Sticklebacks , 2004, PLoS biology.

[38]  Natalie,et al.  Genetic Structure of the Purebred Domestic Dog , 2004 .

[39]  M. Stephens,et al.  Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. , 2003, Genetics.

[40]  G. Barsh,et al.  MC1R studies in dogs with melanistic mask or brindle patterns. , 2003, The Journal of heredity.

[41]  E. Ostrander,et al.  Genetics of the dog , 2001 .

[42]  R. Wayne,et al.  Consequences of domestication: morphological diversity of the dog. , 2001 .

[43]  P. Donnelly,et al.  Inference of population structure using multilocus genotype data. , 2000, Genetics.

[44]  S Rozen,et al.  Primer3 on the WWW for general users and for biologist programmers. , 2000, Methods in molecular biology.

[45]  Se-Jin Lee,et al.  Double muscling in cattle due to mutations in the myostatin gene. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Xianjin Zhou,et al.  Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C , 1995, Nature.

[47]  R. Lovell-Badge Living with bad architecture , 1995, Nature.

[48]  R. Wayne CRANIAL MORPHOLOGY OF DOMESTIC AND WILD CANIDS: THE INFLUENCE OF DEVELOPMENT ON MORPHOLOGICAL CHANGE , 1986, Evolution; international journal of organic evolution.

[49]  B. Weir,et al.  ESTIMATING F‐STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE , 1984, Evolution; international journal of organic evolution.

[50]  S. Wright,et al.  Evolution in Mendelian Populations. , 1931, Genetics.