Quantitative muscle ultrasound detects disease progression in Duchenne muscular dystrophy

We assessed changes in quantitative muscle ultrasound data in boys with Duchenne muscular dystrophy (DMD) and healthy controls to determine whether ultrasound can serve as a biomarker of disease progression. Two approaches were used: gray scale level (GSL), measured from the ultrasound image, and quantitative backscatter analysis (QBA), measured directly from the received echoes.

[1]  L. Servais,et al.  Longitudinal functional and NMR assessment of upper limbs in Duchenne muscular dystrophy , 2016, Neurology.

[2]  O. Bieri,et al.  Quantitative muscle MRI: A powerful surrogate outcome measure in Duchenne muscular dystrophy , 2015, Neuromuscular Disorders.

[3]  A. Pestronk,et al.  Quantitative ultrasound using backscatter analysis in Duchenne and Becker muscular dystrophy , 2010, Neuromuscular Disorders.

[4]  Nens van Alfen,et al.  Quantitative muscle ultrasound is a promising longitudinal follow-up tool in Duchenne muscular dystrophy , 2012, Neuromuscular Disorders.

[5]  C. Zaidman,et al.  Quantitative muscle ultrasound in Duchenne muscular dystrophy: A comparison of techniques , 2015, Muscle & nerve.

[6]  J. Miller,et al.  Clinical trial readiness in non‐ambulatory boys and men with duchenne muscular dystrophy: MDA–DMD network follow‐up , 2016, Muscle & nerve.

[7]  Mark R Holland,et al.  Quantitative ultrasound of skeletal muscle: reliable measurements of calibrated muscle backscatter from different ultrasound systems. , 2012, Ultrasound in medicine & biology.

[8]  K. Kapur,et al.  Electrical impedance myography for assessment of Duchenne muscular dystrophy , 2017, Annals of neurology.

[9]  R. McCarter,et al.  Reliable surrogate outcome measures in multicenter clinical trials of Duchenne muscular dystrophy , 2007, Muscle & nerve.

[10]  Krista Vandenborne,et al.  Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort , 2016, Annals of neurology.

[11]  C. Zaidman,et al.  Minimal training is required to reliably perform quantitative ultrasound of muscle , 2014, Muscle & nerve.

[12]  S. Gasperini,et al.  Functional changes in Duchenne muscular dystrophy , 2011, Neurology.

[13]  C. Zaidman,et al.  Muscle ultrasound quantifies disease progression over time in infants and young boys with duchenne muscular dystrophy , 2015, Muscle & nerve.

[14]  Jay J. Han,et al.  The 6‐minute walk test as a new outcome measure in Duchenne muscular dystrophy , 2010, Muscle & nerve.

[15]  Baziel G M van Engelen,et al.  Skeletal muscle ultrasound: correlation between fibrous tissue and echo intensity. , 2009, Ultrasound in medicine & biology.