Myocardial Contrast Echocardiography

MCE has evolved from a laboratory tool to a clinical procedure. It would be wrong to consider it merely another tool for imaging of myocardial perfusion. As discussed, it allows physicians to bring physiology and pathophysiology to the bedside, providing a better understanding of the underlying mechanisms of abnormal findings in individual patients. MCE can provide quantitative measurements that can be repeated as often as necessary in a patient. Because of its complexity, large clinical studies are necessary to define the role of MCE in the general clinical milieu. Advances in MCE continue at a very rapid pace, and its potential for the study of endothelial function, site-specific targeting, and local delivery of drugs appears promising. Its role will continue to evolve into the early part of the next century. What we learn of the myocardium can be easily applied to other organ systems accessible to ultrasound. The future of MCE appears very exciting.

[1]  S. Kaul,et al.  Myocardial perfusion imaging in the setting of coronary artery stenosis and acute myocardial infarction using venous injection of a second-generation echocardiographic contrast agent. , 1997, Circulation.

[2]  S. Kaul,et al.  Detection of coronary artery disease with myocardial contrast echocardiography: comparison with 99mTc-sestamibi single-photon emission computed tomography. , 1997, Circulation.

[3]  W. Spotnitz,et al.  Deoxygenated blood minimizes adherence of sonicated albumin microbubbles during cardioplegic arrest and after blood reperfusion: experimental and clinical observations with myocardial contrast echocardiography. , 1997, The Journal of thoracic and cardiovascular surgery.

[4]  S. Kaul,et al.  Interactions between microbubbles and ultrasound: in vitro and in vivo observations. , 1997, Journal of the American College of Cardiology.

[5]  S. Kaul,et al.  Myocardial contrast echocardiography in acute myocardial infarction using aortic root injections of microbubbles in conjunction with harmonic imaging: potential application in the cardiac catheterization laboratory. , 1997, Journal of the American College of Cardiology.

[6]  N. Fineberg,et al.  Evaluation of patterns of perfusion and metabolism in dobutamine-responsive myocardium. , 1997, Journal of the American College of Cardiology.

[7]  J. G. Miller,et al.  A novel site-targeted ultrasonic contrast agent with broad biomedical application. , 1996, Circulation.

[8]  M. Phelps,et al.  Effects of dobutamine stimulation on myocardial blood flow, glucose metabolism, and wall motion in normal and dysfunctional myocardium. , 1996, Circulation.

[9]  S. Kaul,et al.  Hemodynamic characteristics, myocardial kinetics and microvascular rheology of FS-069, a second-generation echocardiographic contrast agent capable of producing myocardial opacification from a venous injection. , 1996, Journal of the American College of Cardiology.

[10]  R. Virmani,et al.  Apoptosis in myocytes in end-stage heart failure. , 1996, The New England journal of medicine.

[11]  S. Kaul,et al.  Myocardial contrast echocardiography demonstrates that collateral flow can preserve myocardial function beyond a chronically occluded coronary artery. , 1996, The American journal of cardiology.

[12]  S. Kaul,et al.  Contractile Versus Microvascular Reserve for the Determination of the Extent of Myocardial Salvage After Reperfusion The Effect of Residual Coronary Stenosis , 1996 .

[13]  S. Kaul,et al.  Coronary reserve abnormalities in the infarcted myocardium. Assessment of myocardial viability immediately versus late after reflow by contrast echocardiography. , 1996, Circulation.

[14]  S. Kaul,et al.  Relation between air-filled albumin microbubble and red blood cell rheology in the human myocardium. Influence of echocardiographic systems and chest wall attenuation. , 1996, Circulation.

[15]  E. Geiser,et al.  Inhaled gases affect the ultrasound contrast produced by Albunex in anesthetized dogs. , 1996, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[16]  J. Seward,et al.  Second harmonic imaging of an intravenously administered echocardiographic contrast agent: Visualization of coronary arteries and measurement of coronary blood flow. , 1996, Journal of the American College of Cardiology.

[17]  P. Camici,et al.  Pathophysiology of chronic left ventricular dysfunction. New insights from the measurement of absolute myocardial blood flow and glucose utilization. , 1996, Circulation.

[18]  P. Burns Harmonic imaging with ultrasound contrast agents. , 1996, Clinical radiology.

[19]  P. Grayburn,et al.  Comparison of myocardial contrast echocardiography and low-dose dobutamine stress echocardiography in predicting recovery of left ventricular function after coronary revascularization in chronic ischemic heart disease. , 1995, Circulation.

[20]  S. Kaul,et al.  There may be more to myocardial viability than meets the eye. , 1995, Circulation.

[21]  E. Zajac,et al.  Ability of the no-reflow phenomenon during an acute myocardial infarction to predict left ventricular dysfunction at one-month follow-up. , 1995, The American journal of cardiology.

[22]  T. Porter,et al.  Transient myocardial contrast after initial exposure to diagnostic ultrasound pressures with minute doses of intravenously injected microbubbles. Demonstration and potential mechanisms. , 1995, Circulation.

[23]  P. Grayburn,et al.  Peripheral intravenous myocardial contrast echocardiography using a 2% dodecafluoropentane emulsion: identification of myocardial risk area and infarct size in the canine model of ischemia. , 1995, Journal of the American College of Cardiology.

[24]  A. Arai,et al.  Metabolic adaptation to a gradual reduction in myocardial blood flow. , 1995, Circulation.

[25]  Luis M. Cruz-Orive,et al.  Unbiased estimation of capillary length from vertical slices * , 1995 .

[26]  W. Spotnitz,et al.  New insights into the physiology of retrograde cardioplegia delivery. , 1995, The American journal of physiology.

[27]  S. Kaul,et al.  Technical factors that influence the determination of microbubble transit rate during contrast echocardiography. , 1995, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[28]  S. Vatner,et al.  Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs. Hibernation versus stunning? , 1995, Circulation research.

[29]  W. Spotnitz,et al.  971-56 Myocardial Contrast Echocardiography can be Used to Assess Dynamic Changes in Microvascular Function In-Vivo , 1995 .

[30]  S. Kaul,et al.  Detection of coronary stenoses and quantification of the degree and spatial extent of blood flow mismatch during coronary hyperemia with myocardial contrast echocardiography. , 1995, Circulation.

[31]  S. Kaul,et al.  Identification of viable myocardium with contrast echocardiography in patients with poor left ventricular systolic function caused by recent or remote myocardial infarction. , 1995, The American journal of cardiology.

[32]  G S Kassab,et al.  Morphometry of pig coronary venous system. , 1994, The American journal of physiology.

[33]  B. Vandenberg,et al.  Acoustic lability of albumin microspheres. , 1994, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[34]  M. Hori,et al.  Myocardial salvage: its assessment and prediction by the analysis of serial myocardial contrast echocardiograms in patients with acute myocardial infarction. , 1994, American heart journal.

[35]  Sanjiv Kaul,et al.  Quantification of Myocardial Perfusion With Myocardial Contrast Echocardiography During Left Atrial Injection of Contrast: Implications for Venous Injection , 1994, Circulation.

[36]  C. Autore,et al.  Influence of residual perfusion within the infarct zone on the natural history of left ventricular dysfunction after acute myocardial infarction: a myocardial contrast echocardiographic study. , 1994, Journal of the American College of Cardiology.

[37]  S. Kaul,et al.  Quantification of Images Obtained During Myocardial Contrast Echocardiography , 1994, Echocardiography.

[38]  A. Weyman,et al.  Effect of static pressure on the disappearance rate of specific echocardiographic contrast agents. , 1994, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[39]  T. Skotland,et al.  Lack of an immune response to Albunex, a new ultrasound contrast agent based on air-filled albumin microspheres. , 1994, International archives of allergy and immunology.

[40]  G S Kassab,et al.  Topology and dimensions of pig coronary capillary network. , 1994, The American journal of physiology.

[41]  S. Kaul,et al.  Microvascular integrity indicates myocellular viability in patients with recent myocardial infarction. New insights using myocardial contrast echocardiography. , 1994, Circulation.

[42]  S. Kaul,et al.  In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography. Comparison with radiolabeled red blood cells. , 1994, Circulation research.

[43]  A R Jayaweera,et al.  Effects of radiofrequency catheter ablation on regional myocardial blood flow. Possible mechanism for late electrophysiological outcome. , 1994, Circulation.

[44]  T. Gjøen,et al.  Biodistributions of air-filled albumin microspheres in rats and pigs. , 1994, The Biochemical journal.

[45]  T. Skotland,et al.  Biochemical characterization of air‐filled albumin microspheres , 1993, Biotechnology and applied biochemistry.

[46]  S. Kaul,et al.  Characterization of Spatial Patterns of Flow Within the Reperfused Myocardium by Myocardial Contrast Echocardiography Implications in Determining Extent of Myocardial Salvage , 1993, Circulation.

[47]  P. Serruys,et al.  Intracoronary albunex. Its effects on left ventricular hemodynamics, function, and coronary sinus flow in humans. , 1993, Circulation.

[48]  G. Heusch,et al.  Development of Short‐term Myocardial Hibernation Its Limitation by the Severity of Ischemia and Inotropic Stimulation , 1993, Circulation.

[49]  S. Kaul,et al.  Assessment of Risk Area During Coronary Occlusion and Infarct Size After Reperfusion With Myocardial Contrast Echocardiography Using Left and Right Atrial Injections of Contrast , 1993, Circulation.

[50]  S. Feinstein,et al.  Pitfalls in quantitative contrast echocardiography: the steps to quantitation of perfusion. , 1993, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[51]  G S Kassab,et al.  Morphometry of pig coronary arterial trees. , 1993, The American journal of physiology.

[52]  Nico de Jong,et al.  Acoustic properties of ultrasound contrast agents , 1993 .

[53]  A. Bol,et al.  Mechanisms of Chronic Regional Postischemic Dysfunction in Humans New Insights From the Study of Noninfarcted Collateral‐Dependent Myocardium , 1993, Circulation.

[54]  S. Feinstein,et al.  Myocardial distribution of cardioplegic solution after retrograde delivery in patients undergoing cardiac surgical procedures. , 1993, The Journal of thoracic and cardiovascular surgery.

[55]  S. Kaul,et al.  An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. , 1992, The New England journal of medicine.

[56]  W. Spotnitz,et al.  On-line intraoperative quantitation of regional myocardial perfusion during coronary artery bypass graft operations with myocardial contrast two-dimensional echocardiography. , 1992, The Journal of thoracic and cardiovascular surgery.

[57]  A R Jayaweera,et al.  Myocardial contrast echocardiography and the transmural distribution of flow: a critical appraisal during myocardial ischemia not associated with infarction. , 1992, Journal of the American College of Cardiology.

[58]  T. Takishima,et al.  Microvascular sites and mechanisms responsible for reactive hyperemia in the coronary circulation of the beating canine heart. , 1992, Circulation research.

[59]  S. Kaul,et al.  Functional Significance of Collateral Blood Flow in Patients With Recent Acute Myocardial Infarction: A Study Using Myocardial Contrast Echocardiography , 1992, Circulation.

[60]  A. Kitabatake,et al.  Lack of Myocardial Perfusion Immediately After Successful Thrombolysis: A Predictor of Poor Recovery of Left Ventricular Function in Anterior Myocardial Infarction , 1992, Circulation.

[61]  V. Newhouse,et al.  Simulated Capillary Blood Flow Measurement Using a Nonlinear Ultrasonic Contrast Agent1 , 1992 .

[62]  S. Kaul,et al.  Successful and Reproducible Myocardial Opacification During Two‐dimensional Echocardiography From Right Heart Injection of Contrast , 1992, Circulation.

[63]  E. Ritman,et al.  In Vivo Relation of Intramyocardial Blood Volume to Myocardial Perfusion: Evidence Supporting Microvascular Site for Autoregulation , 1992, Circulation.

[64]  W. Spotnitz,et al.  Microcirculatory Dysfunction Following Perfusion With Hyperkalemic, Hypothermic, Cardioplegic Solutions and Blood Reperfusion: Effects of Adenosine , 1991, Circulation.

[65]  F. Klocke,et al.  First‐Pass Entry of Nonionic Contrast Agent Into the Myocardial Extravascular Space: Effects on Radiographic Estimates of Transit Time and Blood Volume , 1991, Circulation.

[66]  S. Kaul,et al.  Importance of Two‐dimensional Echocardiographic Assessment of Left Ventricular Systolic Function in Patients Presenting to the Emergency Room With Cardiac‐Related Symptoms , 1991, Circulation.

[67]  S. Kaul,et al.  Relation between anterograde blood flow through a coronary artery and the size of the perfusion bed it supplies: experimental and clinical implications. , 1991, Journal of the American College of Cardiology.

[68]  C. Honig,et al.  Intracellular PO2 in individual cardiac myocytes in dogs, cats, rabbits, ferrets, and rats. , 1991, The American journal of physiology.

[69]  S. Kaul,et al.  Value of regional wall motion abnormality in the emergency room diagnosis of acute myocardial infarction. A prospective study using two-dimensional echocardiography. , 1991, Circulation.

[70]  A. M. Lefer,et al.  Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts. , 1990, The American journal of physiology.

[71]  J. Weiss,et al.  Contrast echocardiographic mapping of collateralized myocardium in humans before and after coronary angioplasty. , 1990, Journal of the American College of Cardiology.

[72]  S. Reisner,et al.  Intravenous contrast echocardiography with use of sonicated albumin in humans: systolic disappearance of left ventricular contrast after transpulmonary transmission. , 1990, Journal of the American College of Cardiology.

[73]  W. Spotnitz,et al.  Intraoperative assessment of regional myocardial perfusion using quantitative myocardial contrast echocardiography: an experimental evaluation. , 1990, Journal of the American College of Cardiology.

[74]  F. Van de Werf,et al.  Evidence for decreased coronary flow reserve in viable postischemic myocardium. , 1990, Circulation research.

[75]  T. Kamada,et al.  Coronary collaterals assessed with myocardial contrast echocardiography in healed myocardial infarction. , 1990, The American journal of cardiology.

[76]  F J Ten Cate,et al.  Safety and efficacy of a new transpulmonary ultrasound contrast agent: initial multicenter clinical results. , 1990, Journal of the American College of Cardiology.

[77]  W. Spotnitz,et al.  Intraoperative demonstration of coronary collateral flow using myocardial contrast two-dimensional echocardiography. , 1990, The American journal of cardiology.

[78]  S. Kaul,et al.  Echocardiography in coronary artery disease. , 1990, Current problems in cardiology.

[79]  S S Segal,et al.  The behavior of sonicated albumin microbubbles within the microcirculation: a basis for their use during myocardial contrast echocardiography. , 1989, Circulation research.

[80]  R. Burns,et al.  Myocardial infarction determined by technetium-99m pyrophosphate single-photon tomography complicating elective coronary artery bypass grafting for angina pectoris. , 1989, The American journal of cardiology.

[81]  D D Watson,et al.  Assessment of Regional Myocardial Blood Flow with Myocardial Contrast Two-dimensional Echocardiography , 1989, Journal of the American College of Cardiology.

[82]  S. Kaul,et al.  Albunex: a safe and effective commercially produced agent for myocardial contrast echocardiography. , 1989, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[83]  D D Watson,et al.  Myocardial contrast echocardiography in humans. II. Assessment of coronary blood flow reserve. , 1988, Journal of the American College of Cardiology.

[84]  S. Kaul,et al.  Myocardial contrast echocardiography without significant hemodynamic effects or reactive hyperemia: a major advantage in the imaging of regional myocardial perfusion. , 1988, Journal of the American College of Cardiology.

[85]  J. Bristow,et al.  No reflow and extent of infarction during maximal vasodilation in the porcine heart. , 1988, Circulation.

[86]  W D Spotnitz,et al.  Success of internal mammary bypass grafting can be assessed intraoperatively using myocardial contrast echocardiography. , 1988, Journal of the American College of Cardiology.

[87]  G. Lutty,et al.  Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[88]  B. G. Anderson,et al.  Microvasculature of the bear heart demonstrated by scanning electron microscopy. , 1988, Acta anatomica.

[89]  S. Feinstein,et al.  Effect of intracoronary injections of sonicated microbubbles on left ventricular contractility. , 1987, The American journal of cardiology.

[90]  A. Weyman,et al.  Effects of selectively altering collateral driving pressure on regional perfusion and function in occluded coronary bed in the dog. , 1987, Circulation research.

[91]  A. Weyman,et al.  The importance of defining left ventricular area at risk in vivo during acute myocardial infarction: an experimental evaluation with myocardial contrast two-dimensional echocardiography. , 1987, Circulation.

[92]  F. Neumann,et al.  Myocardial Microcirculation in the Beating Heart — In Vivo Microscopic Studies , 1987 .

[93]  S. Kaul,et al.  Myocardial contrast echocardiography in humans: I. Safety--a comparison with routine coronary arteriography. , 1986, Journal of the American College of Cardiology.

[94]  T. Force,et al.  In vivo prediction of the transmural extent of experimental acute myocardial infarction using contrast echocardiography. , 1986, Journal of the American College of Cardiology.

[95]  J B Newell,et al.  Contrast echocardiography in acute myocardial ischemia. III. An in vivo comparison of the extent of abnormal wall motion with the area at risk for necrosis. , 1986, Journal of the American College of Cardiology.

[96]  J. Drury THE CORONARY SINUS: PROCEEDINGS OF THE 1ST INTERNATIONAL SYMPOSIUM ON MYOCARDIAL PROTECTION VIA THE CORONARY SINUS , 1985 .

[97]  A. Weyman,et al.  Contrast echocardiography in acute myocardial ischemia. II. The effect of site of injection of contrast agent on the estimation of area at risk for necrosis after coronary occlusion. , 1985, Journal of the American College of Cardiology.

[98]  A. Weyman,et al.  Functional and pathologic effects of multiple echocardiographic contrast injections on the myocardium, brain and kidney. , 1985, Journal of the American College of Cardiology.

[99]  G M Pohost,et al.  Contrast echocardiography in acute myocardial ischemia: I. In vivo determination of total left ventricular "area at risk". , 1984, Journal of the American College of Cardiology.

[100]  A. Parisi,et al.  Hydrogen peroxide contrast echocardiography: quantification in vivo of myocardial risk area during coronary occlusion and of the necrotic area remaining after myocardial reperfusion. , 1984, Circulation.

[101]  M. Tschabitscher Anatomy of Coronary Veins , 1984 .

[102]  F J Ten Cate,et al.  Two-dimensional contrast echocardiography. I. In vitro development and quantitative analysis of echo contrast agents. , 1984, Journal of the American College of Cardiology.

[103]  R. Kloner,et al.  Hydrogen peroxide contrast--enhanced two-dimensional echocardiography: real-time in vivo delineation of regional myocardial perfusion. , 1983, Circulation.

[104]  Melvin L.Marcus,et al.  The Coronary Circulation in Health and Disease , 1983 .

[105]  C. Tei,et al.  Myocardial Contrast Echocardiography: A Reproducible Technique of Myocardial Opacification for Identifying Regional Perfusion Deficits , 1983, Circulation.

[106]  E. G. Tickner,et al.  Assessment of Myocardial Perfusion Abnormalities with Contrast‐enhanced Two‐dimensional Echocardiography , 1982, Circulation.

[107]  E. Braunwald,et al.  Ultrastructural Evidence of Microvascular Damage and Myocardial Cell Injury After Coronary Artery Occlusion: Which Comes First? , 1980, Circulation.

[108]  J. Hoffman,et al.  The Role of Autoregulation and Tissue Diastolic Pressures in the Transmural Distribution of Left Ventricular Blood Flow in Anesthetized Dogs , 1979, Circulation research.

[109]  Reimer Ka,et al.  The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. , 1979 .

[110]  J C Greenfield,et al.  Coronary and transmural myocardial blood flow responses in awake domestic pigs. , 1978, The American journal of physiology.

[111]  R. Kloner,et al.  The "no-reflow" phenomenon after temporary coronary occlusion in the dog. , 1974, The Journal of clinical investigation.

[112]  K. Lipscomb,et al.  Effects of coronary stenoses on coronary flow reserve and resistance. , 1974, The American journal of cardiology.

[113]  J B Bassingthwaighte,et al.  Microvasculature of the dog left ventricular myocardium. , 1974, Microvascular research.

[114]  G. Gensini,et al.  The coronary collateral circulation in living man. , 1969, The American journal of cardiology.

[115]  R. Berne,et al.  Regulation of coronary blood flow. , 1975, Progress in cardiovascular diseases.