Vasorelaxant effects of diarylheptanoids, acerogenin A and (−)‐centrolobol from the bark of Acer nikoense

The bark of Acer nikoense (Aceraceae) is used in Japanese folk medicine as a remedy for hepatic disorders and eye diseases. The aim of this study was to investigate the vasorelaxant effects of A. nikoense extracts and further clarify the active constituents and mechanisms of action.

[1]  Takanori Nakamura,et al.  Acylated Triterpene Saponins from the Stem Bark of Acer nikoense (Aceraceae). , 2016, Chemical & pharmaceutical bulletin.

[2]  S. Shin,et al.  Rhododenol and raspberry ketone impair the normal proliferation of melanocytes through reactive oxygen species-dependent activation of GADD45. , 2016, Toxicology in vitro : an international journal published in association with BIBRA.

[3]  Masahiko Inagaki,et al.  Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense. , 2011, Bioorganic & medicinal chemistry letters.

[4]  M. Nagai,et al.  Vasorelaxant effects of Acer nikoense extract and isolated coumarinolignans on rat aortic rings. , 2007, Biological and Pharmaceutical Bulletin.

[5]  H. Tokuda,et al.  Acerogenin M, a cyclic diarylheptanoid, and other phenolic compounds from Acer nikoense and their anti-inflammatory and anti-tumor-promoting effects. , 2006, Chemical & pharmaceutical bulletin.

[6]  A. Singh,et al.  Multiple biological activities of curcumin: a short review. , 2006, Life sciences.

[7]  Y. Chiba,et al.  Relaxing effects of Phellinus gilvus extract and purified ebricoic acid on rat aortic rings , 2006, Journal of Natural Medicines.

[8]  M. Nagai,et al.  Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. , 2006, Biological & pharmaceutical bulletin.

[9]  Li Yang,et al.  Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger. , 2005, Journal of ethnopharmacology.

[10]  S. Kadota,et al.  New diarylheptanoids from the rhizomes of Dioscorea spongiosa and their antiosteoporotic activity. , 2004, Planta medica.

[11]  Masayuki Yoshikawa,et al.  Structures of new cyclic diarylheptanoids and inhibitors of nitric oxide production from Japanese folk medicine Acer nikoense. , 2003, Journal of natural products.

[12]  H. Matsuda,et al.  Medicinal foodstuffs. XXXI. Structures of new aromatic constituents and inhibitors of degranulation in RBL-2H3 cells from a Japanese folk medicine, the stem bark of Acer nikoense. , 2003, Chemical & pharmaceutical bulletin.

[13]  K. Kinoshita,et al.  Antiemetic principles of Alpinia officinarum. , 2002, Journal of natural products.

[14]  S. Kadota,et al.  A new antiplatelet diarylheptanoid from Alpinia blepharocalyx. , 1998, Journal of natural products.

[15]  T. Inoue.  [Constituents of Acer nikoense and Myrica rubra. On diarylheptanoids]. , 1993, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[16]  Takao Inoue,et al.  Studies on the Constituents of Aceraceae Plants. VI. : Revised Stereochemistry of (-)-Centrolobol, and New Glycosides from Acer nikoense , 1986 .

[17]  Takao Inoue,et al.  Studies on the Constituents of Aceraceae Plants. V. Two Diarylheptanoid Glycosides and an Arylbutanol Apiosylglucoside from Acer nikoense , 1983 .

[18]  Takao Inoue,et al.  Studies on the Constituents of Aceraceae Plants. III. Strucure of Acerogenin B from Acer nikoense MAXIM. , 1980 .

[19]  M. Matsuo,et al.  Studies on the Constituents of Aceraceae Plants. II. Structure of Aceroside I, a Glucoside of a Novel Cyclic Diarylheptanoid from Acer nikoense MAXIM. , 1978 .

[20]  M. Nagai,et al.  [Studies on the constituents of Aceraceae plants. I. Constituents in the leaves and the stem bark of Acer nikoense Maxim (author's transl)]. , 1978, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.