Assessment of Dietary Intake of Iodine and Risk of Iodine Deficiency in Children with Classical Galactosaemia on Dietary Treatment

Iodine is an essential mineral required for the synthesis of thyroid hormones. Iodine plays a critical role in growth and neurocognitive development. Classical galactosaemia is a disorder resulting from an inborn error in galactose metabolism. Its current management consists of life-long lactose and galactose dietary restriction. This study estimated dietary intakes of iodine in infants and children with classical galactosaemia in the Republic of Ireland. The diets of 43 participants (aged 7 months–18 years) with classical galactosaemia were assessed for iodine intake using an iodine-specific food frequency questionnaire. Intakes were compared to the European Food Safety Authority (EFSA) dietary recommendations for iodine intake. The potential role of iodine fortification of dairy alternative products was also examined. There were no significant differences observed between sex, ethnicity and parental education and meeting dietary iodine recommendations. Differences, however, were seen between age groups, causing the p value to approach statistical significance (p = 0.06). Infants consuming infant formula were likely to meet iodine recommendations. However, over half (53%) of children aged 1–18 years had average intakes below the recommendations for age. For these children, consumption of iodine-fortified dairy alternative milk was the leading source of iodine in the diets, followed by fish/shellfish and eggs. An assessment of iodine intake should be undertaken during dietetic reviews for those with classical galactosaemia. Mandatory iodine fortification of all dairy alternative products would result in 92% of the total population cohort meeting iodine recommendations based on their current consumption.

[1]  A. Lewiński,et al.  Iodine as a potential endocrine disruptor—a role of oxidative stress , 2022, Endocrine.

[2]  J. Kearney,et al.  Iodine intakes in Irish children aged 5–12 years , 2021, Proceedings of the Nutrition Society.

[3]  U. Alexy,et al.  Age and time trends of dairy intake among children and adolescents of the DONALD study , 2021, European Journal of Nutrition.

[4]  L. Zimmermann,et al.  Pathophysiology and targets for treatment in hereditary galactosemia: A systematic review of animal and cellular models , 2019, Journal of inherited metabolic disease.

[5]  W. Henke,et al.  Galactose 1‐phosphate accumulates to high levels in galactose‐treated cells due to low GALT activity and absence of product inhibition of GALK , 2019, Journal of inherited metabolic disease.

[6]  J. Walton,et al.  Iodine status on the Island of Ireland , 2017 .

[7]  M. Rayman,et al.  Iodine concentration of milk-alternative drinks available in the UK in comparison with cows’ milk , 2017, British Journal of Nutrition.

[8]  Robert L. Jones,et al.  Re: "Iodine Content in Milk Alternatives" by Ma et al. (Thyroid 2016;26:1308-1310). , 2017, Thyroid.

[9]  H. Goenaga-Infante,et al.  Iodine concentration of milk-alternative drinks available in the UK , 2016, Proceedings of the Nutrition Society.

[10]  J. Strain,et al.  Iodine knowledge is positively associated with dietary iodine intake among women of childbearing age in the UK and Ireland , 2016, British Journal of Nutrition.

[11]  J. H. van der Lee,et al.  International clinical guideline for the management of classical galactosemia: diagnosis, treatment, and follow-up , 2016, Journal of Inherited Metabolic Disease.

[12]  Huseyin Kurku,et al.  Increased oxidative stress parameters in children with moderate iodine deficiency , 2016, Journal of pediatric endocrinology & metabolism : JPEM.

[13]  L. Braverman,et al.  Iodine Content in Milk Alternatives. , 2016, Thyroid : official journal of the American Thyroid Association.

[14]  Josef Schlatter,et al.  Draft guidance on the preparation and presentation of a 1 notification for authorisation of Traditional Foods from 2 third countries 3 EFSA Panel on Dietetic Products , Nutrition and Allergies ( NDA ) , 2016 .

[15]  M. Lean,et al.  Iodine and pregnancy – a UK cross-sectional survey of dietary intake, knowledge and awareness , 2015, British Journal of Nutrition.

[16]  S. Skeaff,et al.  Development and validation of an iodine-specific FFQ to estimate iodine intake in Australian pregnant women. , 2015, The British journal of nutrition.

[17]  L. Allen,et al.  Dairy product intake in children and adolescents in developed countries: trends, nutritional contribution, and a review of association with health outcomes. , 2014, Nutrition reviews.

[18]  I. Knerr,et al.  Classical Galactosaemia in Ireland: incidence, complications and outcomes of treatment , 2013, Journal of Inherited Metabolic Disease.

[19]  Efsa Panel on Dietetic Products Scientific Opinion on Dietary Reference Values for iodine. , 2014 .

[20]  J. Franklyn,et al.  Iodine status of UK schoolgirls: a cross-sectional survey , 2011, The Lancet.

[21]  progrAmme mAnAgers Assessment of Iodine Deficiency Disorders and Monitoring their Elimination A guide for programme managers , 2010 .

[22]  M. Zimmermann Iodine deficiency. , 2009, Endocrine reviews.

[23]  Kathleen N. Lohr,et al.  A Systematic Review of the Literature , 2004 .

[24]  C. Ficicioglu,et al.  Galactitol and galactonate in red blood cells of children with the Duarte/galactosemia genotype. , 2005, Molecular genetics and metabolism.

[25]  D. Sheehan,et al.  Goitrogenic and estrogenic activity of soy isoflavones. , 2002, Environmental health perspectives.

[26]  O. Tighe,et al.  Genetic basis of transferase-deficient galactosaemia in Ireland and the population history of the Irish Travellers , 1999, European Journal of Human Genetics.

[27]  S. G. Venkatesh,et al.  A comparative review of the structure and biosynthesis of thyroglobulin. , 1999, Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.

[28]  H. Lightowler,et al.  Iodine intake and iodine deficiency in vegans as assessed by the duplicate-portion technique and urinary iodine excretion , 1998, British Journal of Nutrition.

[29]  J. Reichardt,et al.  Molecular characterization of galactosemia (Type 1)mutations in Japanese , 1995, Human mutation.

[30]  Jacob Cohen,et al.  Set Correlation and Contingency Tables , 1988 .

[31]  Ernestine Becker McCollum,et al.  Modern Nutrition in Health and Disease , 1956 .