DIMETER: A Haptic Master Device for Tremor Diagnosis in Neurodegenerative Diseases

In this study, a device based on patient motion capture is developed for the reliable and non-invasive diagnosis of neurodegenerative diseases. The primary objective of this study is the classification of differential diagnosis between Parkinson's disease (PD) and essential tremor (ET). The DIMETER system has been used in the diagnoses of a significant number of patients at two medical centers in Spain. Research studies on classification have primarily focused on the use of well-known and reliable diagnosis criteria developed by qualified personnel. Here, we first present a literature review of the methods used to detect and evaluate tremor; then, we describe the DIMETER device in terms of the software and hardware used and the battery of tests developed to obtain the best diagnoses. All of the tests are classified and described in terms of the characteristics of the data obtained. A list of parameters obtained from the tests is provided, and the results obtained using multilayer perceptron (MLP) neural networks are presented and analyzed.

[1]  Robert P. W. Duin,et al.  Feature-Based Dissimilarity Space Classification , 2010, ICPR Contests.

[2]  Jyh-Cheng Chen,et al.  A Parkinson’s Disease Measurement System Using Laser Lines and a CMOS Image Sensor , 2011, Sensors.

[3]  Germán Castellanos-Domínguez,et al.  ANÁLISIS DE PROXIMIDAD DE MODELOS OCULTOS DE MARKOV PARA LA IDENTIFICACIÓN DE FUENTES DE ESPIGAS. , 2006 .

[4]  L. A. Gusev,et al.  On an Estimation of the Effectiveness of Computer Diagnosis of Movement Disorders , 2003 .

[5]  K. Bötzel,et al.  Prevalence and incidence of Parkinson's disease in Europe , 2005, European Neuropsychopharmacology.

[6]  Brent C. James,et al.  Diagnostic Error in Medicine , 2018, Diagnosis.

[7]  Rüdiger W. Brause,et al.  Handwriting Analysis for Diagnosis and Prognosis of Parkinson's Disease , 2006, ISBMDA.

[8]  A. C. Scott,et al.  Evaluating the performance of a computer-based consultant. , 1979, Computer programs in biomedicine.

[9]  Elif Derya Übeyli,et al.  Determination of Behcet disease with the application of FFT and AR methods , 2002, Comput. Biol. Medicine.

[10]  Thomas Hummel,et al.  Detection of presymptomatic Parkinson's disease: Combining smell tests, transcranial sonography, and SPECT , 2004, Movement disorders : official journal of the Movement Disorder Society.

[11]  Stanislaw Osowski,et al.  Higher order statistics and neural network for tremor recognition , 2002, IEEE Transactions on Biomedical Engineering.

[12]  T Jones,et al.  The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease. , 1990, Archives of neurology.

[13]  W. Poewe,et al.  Prevalence of movement disorders in men and women aged 50–89 years (Bruneck Study cohort): a population-based study , 2005, The Lancet Neurology.

[14]  J. McNames,et al.  Comparison of Phase-Coupling Indices for Tremor , 2005, Conference Proceedings. 2nd International IEEE EMBS Conference on Neural Engineering, 2005..

[15]  Eta S Berner,et al.  Diagnostic error in medicine: introduction , 2009, Advances in health sciences education : theory and practice.

[16]  Markus Nowak Lonsdale,et al.  Decision Support System for the Diagnosis of Parkinson's Disease , 2005, SCIA.

[17]  J. McNames,et al.  Tracking Tremor Frequency in Spike Trains Using the Extended Kalman Filter , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[18]  E. H. Furnée,et al.  Early detection of Parkinson's disease through automatic movement evaluation. , 1998, IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society.

[19]  A. Hofman,et al.  Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. , 2000, Neurology.

[20]  D. Vaillancourt,et al.  Combined measures of movement and force variability distinguish Parkinson’s disease from essential tremor , 2011, Clinical Neurophysiology.

[21]  Paul McCullagh,et al.  Quantification of body tremor , 1989, Images of the Twenty-First Century. Proceedings of the Annual International Engineering in Medicine and Biology Society,.

[22]  Edward H. Shortliffe,et al.  A rule-based computer program for advising physicians regarding antimicrobial therapy selection , 1974, ACM '74.

[23]  M Laruelle,et al.  Single photon emission computed tomographic imaging demonstrates loss of striatal dopamine transporters in Parkinson disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Russell C. Eberhart,et al.  Human tremor analysis using particle swarm optimization , 1999, Proceedings of the 1999 Congress on Evolutionary Computation-CEC99 (Cat. No. 99TH8406).

[25]  Jeffrey S. Barrett,et al.  Bmc Medical Informatics and Decision Making Integration of Modeling and Simulation into Hospital-based Decision Support Systems Guiding Pediatric Pharmacotherapy , 2008 .

[26]  Edward H. Shortliffe,et al.  Retrospective on "Production Rules as a Representation for a Knowledge-Based Consultation Program" , 1993, Artif. Intell..

[27]  G Becker,et al.  Neuroimaging in basal ganglia disorders: Perspectives for transcranial ultrasound , 2001, Movement disorders : official journal of the Movement Disorder Society.

[28]  Joshua Lederberg,et al.  How DENDRAL was conceived and born , 1987, HMI '87.

[29]  R. O. Duda,et al.  PROSPECTOR—A computer-based consultation system for mineral exploration , 1978 .

[30]  Resul Das,et al.  A comparison of multiple classification methods for diagnosis of Parkinson disease , 2010, Expert Syst. Appl..

[31]  Anne Beuter,et al.  Tremor: Is Parkinson's disease a dynamical disease? , 1995, Chaos.

[32]  G. Gubitz,et al.  Diagnostic Accuracy of Neurological Problems in the Emergency Department , 2008, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[33]  Russell C. Eberhart Tremor quantification using digital actigraphy , 1999, Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. N.

[34]  Ricardo Henao,et al.  Modelos ocultos de Markov en espacios de disimilaridad: Alternativas para la selección de prototipos , 2007 .

[35]  William J. Clancey,et al.  The Epistemology of a Rule-Based Expert System - A Framework for Explanation , 1981, Artif. Intell..

[36]  Suzanne Kieffer,et al.  Feature extraction and selection for objective gait analysis and fall risk assessment by accelerometry , 2011, Biomedical engineering online.

[37]  Alvaro C. D. Faria,et al.  A telemedicine instrument for remote evaluation of tremor: design and initial applications in fatigue and patients with Parkinson's Disease , 2011, Biomedical engineering online.

[38]  K. Ishii,et al.  Fully automatic differential diagnosis system for dementia with Lewy bodies and Alzheimer’s disease using FDG-PET and 3D-SSP , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[39]  Kamiar Aminian,et al.  Quantification of Tremor and Bradykinesia in Parkinson's Disease Using a Novel Ambulatory Monitoring System , 2007, IEEE Transactions on Biomedical Engineering.