Benefits of a scaled differential calculation method for use in a Fabry-Perot based optical cavity biosensor

To lower the overall cost of an optical cavity biosensor, while still taking advantages of highly sensitive Fabry-Perot based optical cavity structures, we have proposed the use of two low cost, off-the-shelf laser diodes and employ a scaled differential calculation method instead of monitoring the intensity changes of a single laser diode. This paper describes three of the benefits of using the scaled differential calculation: enhanced responsivity, power equalization, and an increased fabrication tolerance. Over the same change in sensing layer thickness, the scaled differential value changes three times as much as a single laser. If the starting value of an efficiency curve changes, it will drastically change the results of a single laser measurement. Changes in the starting value of the efficiency do not affect the scaled differential calculation. With the use of the scaled differential calculation, there is a large fabrication tolerance, allowing for cheaper production.

[1]  G. Morthier,et al.  A Label-Free Optical Biosensor Built on a Low-Cost Polymer Platform , 2012, IEEE Photonics Journal.

[2]  Shaker A Mousa,et al.  Biosensors: the new wave in cancer diagnosis. , 2010, Nanotechnology, science and applications.

[3]  Hao Li,et al.  Optofluidic Fabry–Pérot cavity biosensor with integrated flow-through micro-/nanochannels , 2011 .

[4]  G. Whitesides,et al.  Diagnostics for the developing world: microfluidic paper-based analytical devices. , 2010, Analytical chemistry.

[5]  Philippe Lambin,et al.  Rapid Point-Of-Care Breath Test for Biomarkers of Breast Cancer and Abnormal Mammograms , 2014, PloS one.

[6]  Cody Joy,et al.  Demonstration of an optical cavity sensor with a differential detection method by refractive index measurements , 2015, 2015 Texas Symposium on Wireless and Microwave Circuits and Systems (WMCS).

[7]  Robert M. Young,et al.  Fabrication of micronozzles using low-temperature wafer-level bonding with SU-8 , 2003 .

[8]  T. Mason,et al.  A study of ovarian cancer biomarker amplification using ultrasound for early stage detection. , 2014, Ultrasonics.

[9]  Peter Cowles,et al.  Preliminary measurement results of biotinylated BSA detection of a low cost optical cavity based biosensor using differential detection , 2016, SPIE BiOS.

[10]  Avraham Rasooly,et al.  Development of biosensors for cancer clinical testing. , 2006, Biosensors & bioelectronics.

[11]  Tianhua Zhang,et al.  A nanostructured Fabry-Perot interferometer. , 2010, Optics express.