Immunosenescence in multiple sclerosis: The identification of new therapeutic targets.

[1]  R. Flavell,et al.  NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells , 2020, The Journal of experimental medicine.

[2]  F. Matesanz,et al.  NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients. , 2020, Brain : a journal of neurology.

[3]  J. Banchereau,et al.  Sestrins induce natural killer function in senescent-like CD8+ T cells , 2020, Nature Immunology.

[4]  S. Ocklenburg,et al.  Association between shorter leukocyte telomeres and multiple sclerosis , 2020, Journal of Neuroimmunology.

[5]  M. Cancro.  Age-Associated B Cells. , 2020, Annual review of immunology.

[6]  D. Su,et al.  Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging , 2020, Immunity & Ageing.

[7]  A. Salminen.  Activation of immunosuppressive network in the aging process , 2019, Ageing Research Reviews.

[8]  E. van Hoffen,et al.  Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women , 2019, PloS one.

[9]  S. Dietmann,et al.  Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells , 2019, Cell stem cell.

[10]  Simon C. Potter,et al.  Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility , 2019, Science.

[11]  M. Ramanathan,et al.  Epidemiology and treatment of multiple sclerosis in elderly populations , 2019, Nature Reviews Neurology.

[12]  Till F. M. Andlauer,et al.  A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis , 2019, Nature Communications.

[13]  Z. Calamita,et al.  Effects of Immunosenescence on the Lower Expression of Surface Molecules in Neutrophils and Lymphocytes. , 2019, Current aging science.

[14]  M. Khademi,et al.  B cell alterations during BAFF inhibition with belimumab in SLE , 2018, EBioMedicine.

[15]  V. Gorgoulis,et al.  Ageing, Cellular Senescence and Neurodegenerative Disease , 2018, International journal of molecular sciences.

[16]  J. Laman,et al.  Targeting senescence to delay progression of multiple sclerosis , 2018, Journal of Molecular Medicine.

[17]  D. Centonze,et al.  Interplay Between Age and Neuroinflammation in Multiple Sclerosis: Effects on Motor and Cognitive Functions , 2018, Front. Aging Neurosci..

[18]  I. Bjelobaba,et al.  Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis , 2018, Journal of neuroscience research.

[19]  D. Allison,et al.  Senolytics Improve Physical Function and Increase Lifespan in Old Age , 2018, Nature Medicine.

[20]  Young Shin Song,et al.  Transcriptome Network Analysis Reveals Aging-Related Mitochondrial and Proteasomal Dysfunction and Immune Activation in Human Thyroid , 2018, Thyroid : official journal of the American Thyroid Association.

[21]  G. Fenu,et al.  New horizons for multiple sclerosis therapeutics: milestones in the development of ocrelizumab , 2018, Neuropsychiatric disease and treatment.

[22]  E. Costantini,et al.  The Role of Immunosenescence in Neurodegenerative Diseases , 2018, Mediators of inflammation.

[23]  C. Bolton,et al.  The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE) , 2018, Ageing Research Reviews.

[24]  Beibei Wang,et al.  T‐cell Immunoglobulin and ITIM Domain Contributes to CD8+ T‐cell Immunosenescence , 2018, Aging cell.

[25]  X. Montalban,et al.  Combined therapies to treat complex diseases: The role of the gut microbiota in multiple sclerosis. , 2017, Autoimmunity reviews.

[26]  A. Díaz,et al.  Aging effects on T-bet expression in human B cell subsets. , 2017, Cellular immunology.

[27]  S. Nourshargh,et al.  Human CD8+ EMRA T cells display a senescence‐associated secretory phenotype regulated by p38 MAPK , 2017, Aging cell.

[28]  Lingling Wu,et al.  T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus , 2017, Arthritis Research & Therapy.

[29]  M. Cameron,et al.  This information is current as Receptor Agonists Aging in Response to Pattern Recognition inTranscriptionally and Functionally Altered Human Monocyte Subsets Are , 2017 .

[30]  N. Scolding,et al.  Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro , 2017, Multiple sclerosis.

[31]  W. Graninger,et al.  Novel Senescent Regulatory T-Cell Subset with Impaired Suppressive Function in Rheumatoid Arthritis , 2017, Front. Immunol..

[32]  A. Díaz,et al.  Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways , 2017, Experimental Gerontology.

[33]  B. Balint,et al.  B-cell populations discriminate between pediatric- and adult-onset multiple sclerosis , 2016, Neurology: Neuroimmunology & Neuroinflammation.

[34]  Dong Oh Kim,et al.  Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity , 2016, Nature Communications.

[35]  N. Hellings,et al.  Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients , 2016, The Journal of Immunology.

[36]  B. Pereira,et al.  Convergence of Innate and Adaptive Immunity during Human Aging , 2016, Front. Immunol..

[37]  Q. Zhuge,et al.  Friend or foe: the dichotomous impact of T cells on neuro-de/re-generation during aging , 2016, Oncotarget.

[38]  T. Morgan,et al.  A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. , 2016, Cell reports.

[39]  C. Chougnet,et al.  Loss of phagocytic and antigen cross-presenting capacity in aging DCs is associated with mitochondrial dysfunction , 2016, The Journal of Immunology.

[40]  I. Barshack,et al.  Aging affects B‐cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues , 2016, European journal of immunology.

[41]  N. Sharpless,et al.  Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice , 2015, Nature Medicine.

[42]  M. I. Crespo,et al.  Aging Impairs the Ability of Conventional Dendritic Cells to Cross-Prime CD8+ T Cells upon Stimulation with a TLR7 Ligand , 2015, PloS one.

[43]  T. Mora,et al.  A Reassessment of IgM Memory Subsets in Humans , 2015, The Journal of Immunology.

[44]  R. Franklin,et al.  Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. , 2015, Brain : a journal of neurology.

[45]  A. Pera,et al.  Immunosenescence: Implications for response to infection and vaccination in older people. , 2015, Maturitas.

[46]  A. Díaz,et al.  MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals , 2015, The Journal of Immunology.

[47]  Ruth R. Montgomery,et al.  Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes , 2015, Oncotarget.

[48]  R. Sedaghat,et al.  Therapeutic effects of dasatinib in mouse model of multiple sclerosis , 2015, Immunopharmacology and immunotoxicology.

[49]  E. Steinhagen-Thiessen,et al.  Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study , 2015, Biogerontology.

[50]  F. Jacques.  Defining the clinical course of multiple sclerosis: The 2013 revisions , 2015, Neurology.

[51]  K. Schroder,et al.  A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases , 2015, Nature Medicine.

[52]  T. Maeda,et al.  Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening , 2015, Molecular and Cellular Biochemistry.

[53]  H. D. de Vries,et al.  IL-15 Amplifies the Pathogenic Properties of CD4+CD28− T Cells in Multiple Sclerosis , 2015, The Journal of Immunology.

[54]  Richard A. Olshen,et al.  Diversity and clonal selection in the human T-cell repertoire , 2014, Proceedings of the National Academy of Sciences.

[55]  Elizabeth Sapey,et al.  Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals , 2014, Aging cell.

[56]  E. Gardner,et al.  Natural killer cell development and maturation in aged mice , 2014, Mechanisms of Ageing and Development.

[57]  R. Riley.  Impaired B lymphopoiesis in old age: a role for inflammatory B cells? , 2013, Immunologic research.

[58]  M. Pirinen,et al.  Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis , 2013, Nature Genetics.

[59]  S. Fuchs,et al.  Age dependent course of EAE in Aire−/− mice , 2013, Journal of Neuroimmunology.

[60]  R. Würzner,et al.  Lower CD28+ T cell proportions were associated with CMV-seropositivity in patients with Hashimoto’s thyroiditis , 2013, BMC Endocrine Disorders.

[61]  F. Paul,et al.  T-cell homeostasis in pediatric multiple sclerosis , 2013, Neurology.

[62]  N. McGovern,et al.  Human dendritic cell subsets , 2013, Immunology.

[63]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[64]  M. Grounds,et al.  Targeting macrophages rescues age‐related immune deficiencies in C57BL/6J geriatric mice , 2013, Aging cell.

[65]  P. Lang,et al.  Reversing T cell immunosenescence: why, who, and how , 2013, AGE.

[66]  Hanne F. Harbo,et al.  Sex and gender issues in multiple sclerosis , 2013, Therapeutic advances in neurological disorders.

[67]  I. Bruce,et al.  Shortened telomere length in patients with systemic lupus erythematosus. , 2013, Arthritis and rheumatism.

[68]  E. Meffre,et al.  Expansion of autoreactive unresponsive CD21-/low B cells in Sjögren's syndrome-associated lymphoproliferation. , 2013, Arthritis and rheumatism.

[69]  B. Weinshenker,et al.  Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis , 2013, Multiple sclerosis.

[70]  M. Gunzer,et al.  Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. , 2012, Cell stem cell.

[71]  Siddharthan Chandran,et al.  Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency. , 2012, The American journal of pathology.

[72]  R. Jenq,et al.  Interleukin-22 Drives Endogenous Thymic Regeneration in Mice , 2012, Science.

[73]  C. Weyand,et al.  Immune aging and autoimmunity , 2012, Cellular and Molecular Life Sciences.

[74]  R. Franklin,et al.  Rejuvenation of regeneration in the aging central nervous system. , 2012, Cell stem cell.

[75]  A. D. de Craen,et al.  Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans. , 2011, The Journal of general virology.

[76]  P. Marrack,et al.  Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity. , 2011, Blood.

[77]  Simon C. Potter,et al.  Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis , 2011, Nature.

[78]  S. Burrows,et al.  CD8 T cell deficiency impairs control of Epstein–Barr virus and worsens with age in multiple sclerosis , 2011, Journal of Neurology, Neurosurgery & Psychiatry.

[79]  C. Siegrist,et al.  Vaccine effectiveness in older individuals: What has been learned from the influenza-vaccine experience , 2011, Ageing Research Reviews.

[80]  A. Ordóñez,et al.  Age-related deregulation of naive T cell homeostasis in elderly humans , 2011, AGE.

[81]  A. Bar-Or,et al.  Reduced thymic output and peripheral naïve CD4 T-cell alterations in primary progressive multiple sclerosis (PPMS) , 2011, Journal of Neuroimmunology.

[82]  M. Cancro,et al.  A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. , 2011, Blood.

[83]  C. Harley,et al.  A natural product telomerase activator as part of a health maintenance program. , 2011, Rejuvenation research.

[84]  Istvan Pirko,et al.  The relevance of animal models in multiple sclerosis research. , 2011, Pathophysiology : the official journal of the International Society for Pathophysiology.

[85]  L. Rodrigo,et al.  NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system , 2011, AGE.

[86]  P. Debré,et al.  Human NK cells display major phenotypic and functional changes over the life span , 2010, Aging cell.

[87]  Yang Liu,et al.  mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells , 2009, Science Signaling.

[88]  Hans Lassmann,et al.  The relation between inflammation and neurodegeneration in multiple sclerosis brains , 2009, Brain : a journal of neurology.

[89]  J. Tay,et al.  Increased Reactivity of Dendritic Cells from Aged Subjects to Self-Antigen, the Human DNA1 , 2009, The Journal of Immunology.

[90]  F. Munschauer,et al.  Quercetin and interferon-β modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients , 2008, Journal of Neuroimmunology.

[91]  E. Rosato,et al.  Immunity, autoimmunity and autoimmune diseases in older people. , 2008, Journal of biological regulators and homeostatic agents.

[92]  S. Miller,et al.  Encephalomyelitis Experimental Autoimmune Age-associated Onset of Spontaneous Intrinsic and Induced Regulation of the Intrinsic and Induced Regulation of the Age-associated Onset of Spontaneous Experimental Autoimmune Encephalomyelitisa-7 and Rg 3965-a-8, and a Grant from the Myelin Repair Foundatio , 2022 .

[93]  Xue-guang Zhang,et al.  Association of Graves’ Disease and Prevalence of Circulating IFN-γ-producing CD28− T Cells , 2008, Journal of Clinical Immunology.

[94]  J. Lünemann,et al.  EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2 , 2008, The Journal of experimental medicine.

[95]  P. Geusens,et al.  Analyses of immunosenescent markers in patients with autoimmune disease. , 2007, Clinical immunology.

[96]  J. Heeney,et al.  Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination. , 2007, Rejuvenation research.

[97]  D. Min,et al.  Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. , 2007, Blood.

[98]  G. Castellani,et al.  Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans , 2007, Mechanisms of Ageing and Development.

[99]  G. Pawelec,et al.  Aging and innate immunity. , 2006, Immunity.

[100]  C. Caruso,et al.  Memory B cell subpopulations in the aged. , 2006, Rejuvenation research.

[101]  Keisuke Ito,et al.  Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells , 2006, Nature Medicine.

[102]  I. Weissman,et al.  Cell intrinsic alterations underlie hematopoietic stem cell aging. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[103]  P. Geusens,et al.  Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients , 2005, Annals of the New York Academy of Sciences.

[104]  A. Vallejo,et al.  The Influence of Age on T Cell Generation and TCR Diversity1 , 2005, The Journal of Immunology.

[105]  A. Vallejo,et al.  CD28 extinction in human T cells: altered functions and the program of T‐cell senescence , 2005, Immunological reviews.

[106]  L. Haynes,et al.  The effect of age on the cognate function of CD4+ T cells , 2005, Immunological reviews.

[107]  G. Pawelec,et al.  An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans. , 2005, The journals of gerontology. Series A, Biological sciences and medical sciences.

[108]  R. Würzner,et al.  Long-Term Cytomegalovirus Infection Leads to Significant Changes in the Composition of the CD8+ T-Cell Repertoire, Which May Be the Basis for an Imbalance in the Cytokine Production Profile in Elderly Persons , 2005, Journal of Virology.

[109]  D. Macció,et al.  Age-related changes in the development of experimental autoimmune encephalomyelitis. , 2005, Immunology and cell biology.

[110]  R. Simon,et al.  Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis , 2004, The Journal of Immunology.

[111]  J. Blattman,et al.  Restoration of CD28 Expression in CD28− CD8+ Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production , 2003, The Journal of experimental medicine.

[112]  R. Frye,et al.  De Novo Expression of Killer Immunoglobulin‐Like Receptors and Signaling Proteins Regulates the Cytotoxic Function of CD4 T Cells in Acute Coronary Syndromes , 2003, Circulation research.

[113]  M. García-Carrasco,et al.  Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly , 2003, Lupus.

[114]  A. Vallejo,et al.  CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation. , 2003, Blood.

[115]  H. Hartung,et al.  Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial , 2002, The Lancet.

[116]  J. Katz,et al.  Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging , 2002, The Journal of Immunology.

[117]  E. Sapey,et al.  Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans , 2001, Journal of leukocyte biology.

[118]  A. Celada,et al.  IFN-γ-dependent transcription of MHC class II IA is impaired in macrophages from aged mice , 2001 .

[119]  R. Solana,et al.  Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells , 2001, Mechanisms of Ageing and Development.

[120]  C. Franceschi,et al.  Inflamm‐aging: An Evolutionary Perspective on Immunosenescence , 2000 .

[121]  C. Franceschi,et al.  Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. , 2000, Blood.

[122]  A Steinle,et al.  Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. , 1999, Science.

[123]  F. Borrego,et al.  NK phenotypic markers and IL2 response in NK cells from elderly people , 1999, Experimental Gerontology.

[124]  R. Voll,et al.  Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. , 1998, Arthritis and rheumatism.

[125]  C. Weyand,et al.  Functional properties of CD4+CD28− T cells in the aging immune system , 1998, Mechanisms of Ageing and Development.

[126]  C. Weyand,et al.  CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. , 1996, The Journal of clinical investigation.

[127]  Shotai Kobayashi,et al.  Antinuclear antibodies in healthy aging people: a prospective study , 1995, Mechanisms of Ageing and Development.

[128]  D. Hafler,et al.  MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. , 1993, Science.

[129]  N. Rhodus.  Xerostomia and the geriatric patient. , 1988, Dentistry.

[130]  H. Weiner,et al.  Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions , 1986, Annals of neurology.

[131]  T. Olsson,et al.  Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis , 2017, Nature Reviews Neurology.

[132]  I. Baumann,et al.  Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. , 2002, Arthritis and rheumatism.

[133]  C. Weyand,et al.  CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. , 2001, Arthritis and rheumatism.

[134]  S. P. Akpabio.  World Health Organisation , 1983, British Dental Journal.

[135]  J. Mussini,et al.  [Immunology of multiple sclerosis]. , 1982, La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris.

[136]  W. L. Benedict,et al.  Multiple Sclerosis , 2007, Journal - Michigan State Medical Society.