Adaptations in pulsatile insulin secretion, hepatic insulin clearance, and beta-cell mass to age-related insulin resistance in rats.
暂无分享,去创建一个
[1] P. Butler,et al. Measurement of pulsatile insulin secretion in the rat: direct sampling from the hepatic portal vein. , 2008, American journal of physiology. Endocrinology and metabolism.
[2] A. DeAngelis. CEACAM1: A Link Between Insulin and Lipid Metabolism , 2008 .
[3] R. Rizza,et al. β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans , 2008, Diabetes.
[4] W. Uhl,et al. Partial Pancreatectomy in Adult Humans Does Not Provoke β-Cell Regeneration , 2008, Diabetes.
[5] W. Uhl,et al. Partial pancreatectomy in adult humans does not provoke beta-cell regeneration. , 2008, Diabetes.
[6] Xueying Gu,et al. Menin Controls Growth of Pancreatic ß-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus , 2007, Science.
[7] R. Rizza,et al. High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes , 2007, Diabetes.
[8] J. Kench,et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes , 2007, Diabetologia.
[9] Seung K. Kim,et al. Intrinsic Regulators of Pancreatic β-Cell Proliferation , 2006 .
[10] P. Butler,et al. Mechanisms of Impaired Fasting Glucose and Glucose Intolerance Induced by a ∼50% Pancreatectomy , 2006, Diabetes.
[11] P. Butler,et al. β-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2 Diabetes , 2006, Diabetes.
[12] H. Wootz,et al. ER stress and neurodegenerative diseases , 2006, Cell Death and Differentiation.
[13] A. Chang,et al. Limitation of the homeostasis model assessment to predict insulin resistance and beta-cell dysfunction in older people. , 2006, The Journal of clinical endocrinology and metabolism.
[14] Seung K. Kim,et al. Intrinsic regulators of pancreatic beta-cell proliferation. , 2006, Annual review of cell and developmental biology.
[15] P. Butler,et al. Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes. , 2006, Diabetes.
[16] J. Kushner,et al. Very Slow Turnover of β-Cells in Aged Adult Mice , 2005 .
[17] Johannes D Veldhuis,et al. Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans. , 2005, Diabetes.
[18] O. McGuinness,et al. Impact of continuous and pulsatile insulin delivery on net hepatic glucose uptake. , 2005, American journal of physiology. Endocrinology and metabolism.
[19] J. Kushner,et al. Very slow turnover of beta-cells in aged adult mice. , 2005, Diabetes.
[20] Gil Atzmon,et al. Decrease in glucose-stimulated insulin secretion with aging is independent of insulin action. , 2004, Diabetes.
[21] R. DeFronzo,et al. Hepatic and peripheral insulin resistance: A common feature of Type 2 (non-insulin-dependent) and Type 1 (insulin-dependent) diabetes mellitus , 1982, Diabetologia.
[22] W. Soeller,et al. Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid. , 2003, Diabetes.
[23] Claudio Cobelli,et al. Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. , 2003, Diabetes.
[24] Robert A. Rizza,et al. β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes , 2003, Diabetes.
[25] S. Najjar. Regulation of insulin action by CEACAM1 , 2002, Trends in Endocrinology & Metabolism.
[26] Y. Kido,et al. CEACAM1 regulates insulin clearance in liver , 2002, Nature Genetics.
[27] M. Stumvoll,et al. Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans. , 2002, Diabetes.
[28] Jean-Pierre Paccaud,et al. Two Steps of Insulin Receptor Internalization Depend on Different Domains of the/3-Subunit , 2002 .
[29] M. Straume,et al. Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig. , 2001, Diabetes.
[30] J D Veldhuis,et al. Direct measurement of pulsatile insulin secretion from the portal vein in human subjects. , 2000, The Journal of clinical endocrinology and metabolism.
[31] R. Bergman,et al. Longitudinal Compensation for Fat-induced Insulin Resistance Includes Reduced Insulin Clearance and Enhanced -cell Response Research Design and Methods , 2022 .
[32] N. Porksen,et al. Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes. , 2000, American journal of physiology. Endocrinology and metabolism.
[33] E. Montanya,et al. Linear correlation between beta-cell mass and body weight throughout the lifespan in Lewis rats: role of beta-cell hyperplasia and hypertrophy. , 2000, Diabetes.
[34] N. Barzilai,et al. Ability of insulin to modulate hepatic glucose production in aging rats is impaired by fat accumulation. , 2000, American journal of physiology. Endocrinology and metabolism.
[35] E. Montanya,et al. Linear Correlation Between -Cell Mass and Body Weight Throughout the Lifespan in Lewis Rats Role of -Cell Hyperplasia and Hypertrophy , 2000 .
[36] J D Veldhuis,et al. Disruption of the pulsatile and entropic modes of insulin release during an unvarying glucose stimulus in elderly individuals. , 1999, The Journal of clinical endocrinology and metabolism.
[37] A Mari,et al. Free fatty acids impair hepatic insulin extraction in vivo. , 1999, Diabetes.
[38] N. Barzilai,et al. Surgical removal of visceral fat reverses hepatic insulin resistance. , 1999, Diabetes.
[39] W. Duckworth,et al. Insulin degradation: progress and potential. , 1998, Endocrine reviews.
[40] G Pacini,et al. Age-related reduction in glucose elimination is accompanied by reduced glucose effectiveness and increased hepatic insulin extraction in man. , 1998, The Journal of clinical endocrinology and metabolism.
[41] Wei Chen,et al. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. , 1998, The Journal of clinical investigation.
[42] N. Porksen,et al. Effects of Glucose Ingestion Versus Infusion on Pulsatile Insulin Secretion: The Incretin Effect Is Achieved by Amplification of Insulin Secretory Burst Mass , 1996, Diabetes.
[43] N. Porksen,et al. Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass. , 1996, The American journal of physiology.
[44] N. Porksen,et al. Pulsatile insulin secretion accounts for 70% of total insulin secretion during fasting. , 1995, The American journal of physiology.
[45] J. Sturis,et al. Alterations in the Patterns of Insulin Secretion Before and After Diagnosis of IDDM , 1995, Diabetes Care.
[46] S. Bonner-Weir,et al. Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical Model , 1995, Diabetes.
[47] J. Leahy,et al. Diazoxide Causes Recovery of β-Cell Glucose Responsiveness in 90% Pancreatectomized Diabetic Rats , 1994, Diabetes.
[48] R. Bergman,et al. Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function , 1993, Diabetes.
[49] L Orci,et al. Two steps of insulin receptor internalization depend on different domains of the beta-subunit [published erratum appears in J Cell Biol 1993 Nov;123(4):1047] , 1993, The Journal of cell biology.
[50] A. Goldberg,et al. Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age. , 1992, The Journal of clinical endocrinology and metabolism.
[51] A. Valerio,et al. Reduced Beta‐Cell Secretion and Insulin Hepatic Extraction in Healthy Elderly Subjects , 1990, Journal of the American Geriatrics Society.
[52] A. Ullrich,et al. Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit. , 1990, The Journal of biological chemistry.
[53] M. Cerqueira,et al. Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging. , 1990, The American journal of physiology.
[54] R. Rizza,et al. Effects of Meal Ingestion on Plasma Amylin Concentration in NIDDM and Nondiabetic Humans , 1990, Diabetes.
[55] P. Björntorp,et al. Free–Fatty Acid Inhibition of Insulin Binding, Degradation, and Action in Isolated Rat Hepatocytes , 1990, Diabetes.
[56] K. Polonsky,et al. Effects of Aging on Insulin Secretion , 1989, Diabetes.
[57] D. Owens,et al. INSULIN DEFICIENCY IN NON-INSULIN-DEPENDENT DIABETES , 1989, The Lancet.
[58] J. Olefsky,et al. The Metabolic Clearance of Insulin and the Feedback Inhibition of Insulin Secretion Are Altered with Aging , 1985, Diabetes.
[59] D. James,et al. Dose-response curves for in vivo insulin sensitivity in individual tissues in rats. , 1985, The American journal of physiology.
[60] M. Löhr,et al. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. , 1985, Survey and synthesis of pathology research.
[61] E. Bonora,et al. Decreased hepatic insulin extraction in subjects with mild glucose intolerance. , 1983, Metabolism: clinical and experimental.
[62] H. Kehlet,et al. Decreased insulin removal contributes to hyperinsulinemia in obesity. , 1981, The Journal of clinical endocrinology and metabolism.
[63] Claudio Cobelli,et al. Physiologic Evaluation of Factors Controlling , 1981 .
[64] K. Kosaka,et al. Isoproterenol-stimulated C-peptide and insulin secretion in diabetic and nonobese normal subjects: decreased hepatic extraction of endogenous insulin in diabetes. , 1980, The Journal of clinical endocrinology and metabolism.
[65] D. Kipnis,et al. Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic sujbjects. , 1967, The Journal of clinical investigation.
[66] M. T. Brennan,et al. Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. , 1967, The Journal of clinical investigation.