Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion
暂无分享,去创建一个
Christian Fuchsberger | Tanya M. Teslovich | Johanna Kuusisto | Hyun Min Kang | Michael Boehnke | Alena Stančáková | Benjamin M Neale | Mark J Daly | Jeroen R Huyghe | Francis S Collins | Gonçalo R Abecasis | Xueling Sim | Lingyao Yang | Karen L Mohlke | Hua Ling | Roxann Ingersoll | Laura J Scott | Richard M Watanabe | Kimberly F Doheny | Elizabeth W Pugh | M. Daly | G. Abecasis | H. Kang | M. Laakso | F. Collins | M. Boehnke | B. Neale | K. Doheny | L. Scott | K. Mohlke | H. Stringham | P. Chines | A. Jackson | R. Watanabe | E. Pugh | X. Sim | A. Stančáková | J. Kuusisto | M. Buchkovich | I. McMullen | C. Fuchsberger | Lingyao Yang | Jane M. Romm | J. Huyghe | H. Ling | R. Ingersoll | Markku Laakso | Tanya M Teslovich | H. Cederberg | Anne U Jackson | Peter S Chines | Heather M Stringham | Ivy McMullen | Henna Cederberg | Martin L. Buchkovich | M. Fogarty | Marie P Fogarty | Martin L Buchkovich | Jane M Romm | Ivy McMullen | R. Watanabe | A. Jackson
[1] Cedric Gondro,et al. Quality control for genome-wide association studies. , 2013, Methods in molecular biology.
[2] Xihong Lin,et al. Optimal tests for rare variant effects in sequencing association studies. , 2012, Biostatistics.
[3] Tanya M. Teslovich,et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways , 2012, Nature Genetics.
[4] R. Mains,et al. Signaling from the secretory granule to the nucleus , 2012, Critical reviews in biochemistry and molecular biology.
[5] Adam Kiezun,et al. Exome sequencing and the genetic basis of complex traits , 2012, Nature Genetics.
[6] Claude Bouchard,et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance , 2012, Nature Genetics.
[7] Yusuke Nakamura,et al. A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population , 2012, Nature Genetics.
[8] J. Silberg,et al. A transposase strategy for creating libraries of circularly permuted proteins , 2012, Nucleic acids research.
[9] The UniProt Consortium,et al. Reorganizing the protein space at the Universal Protein Resource (UniProt) , 2011, Nucleic Acids Res..
[10] E. Oetjen,et al. Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes , 2011, Diabetes.
[11] D. Lambright,et al. RUTBC1 Protein, a Rab9A Effector That Activates GTP Hydrolysis by Rab32 and Rab33B Proteins* , 2011, The Journal of Biological Chemistry.
[12] Xihong Lin,et al. Rare-variant association testing for sequencing data with the sequence kernel association test. , 2011, American journal of human genetics.
[13] A. Kowluru. Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches. , 2011, Biochemical pharmacology.
[14] David I. Wilson,et al. In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets , 2010, The Journal of endocrinology.
[15] Ayellet V. Segrè,et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis , 2010, Nature Genetics.
[16] H. Kang,et al. Variance component model to account for sample structure in genome-wide association studies , 2010, Nature Genetics.
[17] P. Bork,et al. A method and server for predicting damaging missense mutations , 2010, Nature Methods.
[18] T. Assimes,et al. Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans , 2010, Diabetes.
[19] Christian Gieger,et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , 2010, Nature Genetics.
[20] Geoffrey S. Tobias,et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer , 2009, Nature Genetics.
[21] M. Laakso,et al. Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men , 2009, Diabetes.
[22] Y. Wang,et al. Kank proteins: structure, functions and diseases , 2009, Cellular and Molecular Life Sciences.
[23] P. Halban,et al. Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function. , 2009, Endocrinology.
[24] Johanna Kuusisto,et al. Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men , 2009, Diabetes.
[25] M. Fukuda,et al. Identification and characterization of a novel Tre‐2/Bub2/Cdc16 (TBC) protein that possesses Rab3A‐GAP activity , 2009, Genes to cells : devoted to molecular & cellular mechanisms.
[26] R. Collins,et al. Common variants at 30 loci contribute to polygenic dyslipidemia , 2009, Nature Genetics.
[27] C. Hoggart,et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population , 2008, Nature Genetics.
[28] L. Maquat,et al. The multiple lives of NMD factors: balancing roles in gene and genome regulation , 2008, Nature Reviews Genetics.
[29] B. Zinman,et al. Hyperbolic Relationship Between Insulin Secretion and Sensitivity on Oral Glucose Tolerance Test , 2008, Obesity.
[30] K. Shianna,et al. Long-range LD can confound genome scans in admixed populations. , 2008, American journal of human genetics.
[31] C. Haley,et al. Genomewide Rapid Association Using Mixed Model and Regression: A Fast and Simple Method For Genomewide Pedigree-Based Quantitative Trait Loci Association Analysis , 2007, Genetics.
[32] Manuel A. R. Ferreira,et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.
[33] S. Minoshima,et al. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. , 2007, Genomics.
[34] F. Barr,et al. Functional dissection of Rab GTPases involved in primary cilium formation , 2007, The Journal of cell biology.
[35] Yurii S. Aulchenko,et al. BIOINFORMATICS APPLICATIONS NOTE doi:10.1093/bioinformatics/btm108 Genetics and population analysis GenABEL: an R library for genome-wide association analysis , 2022 .
[36] D. Reich,et al. Population Structure and Eigenanalysis , 2006, PLoS genetics.
[37] J. Harrow,et al. GENCODE: producing a reference annotation for ENCODE , 2006, Genome Biology.
[38] Guy A Rutter,et al. Insulin vesicle release: walk, kiss, pause ... then run. , 2006, Physiology.
[39] R. Mains,et al. Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. , 2005, Developmental biology.
[40] R. Turner,et al. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.
[41] B. Wicksteed,et al. Insulin Secretory Deficiency and Glucose Intolerance in Rab3A Null Mice* , 2003, The Journal of Biological Chemistry.
[42] R. Regazzi,et al. The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells. , 2002, The Biochemical journal.
[43] M. Stumvoll,et al. Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. , 2001, Diabetes care.
[44] K. Roeder,et al. Genomic Control for Association Studies , 1999, Biometrics.
[45] M. Matsuda,et al. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. , 1999, Diabetes care.
[46] C. Wollheim,et al. Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. , 1996, Journal of cell science.