Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

[1]  Cedric Gondro,et al.  Quality control for genome-wide association studies. , 2013, Methods in molecular biology.

[2]  Xihong Lin,et al.  Optimal tests for rare variant effects in sequencing association studies. , 2012, Biostatistics.

[3]  Tanya M. Teslovich,et al.  Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways , 2012, Nature Genetics.

[4]  R. Mains,et al.  Signaling from the secretory granule to the nucleus , 2012, Critical reviews in biochemistry and molecular biology.

[5]  Adam Kiezun,et al.  Exome sequencing and the genetic basis of complex traits , 2012, Nature Genetics.

[6]  Claude Bouchard,et al.  A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance , 2012, Nature Genetics.

[7]  Yusuke Nakamura,et al.  A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population , 2012, Nature Genetics.

[8]  J. Silberg,et al.  A transposase strategy for creating libraries of circularly permuted proteins , 2012, Nucleic acids research.

[9]  The UniProt Consortium,et al.  Reorganizing the protein space at the Universal Protein Resource (UniProt) , 2011, Nucleic Acids Res..

[10]  E. Oetjen,et al.  Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes , 2011, Diabetes.

[11]  D. Lambright,et al.  RUTBC1 Protein, a Rab9A Effector That Activates GTP Hydrolysis by Rab32 and Rab33B Proteins* , 2011, The Journal of Biological Chemistry.

[12]  Xihong Lin,et al.  Rare-variant association testing for sequencing data with the sequence kernel association test. , 2011, American journal of human genetics.

[13]  A. Kowluru Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches. , 2011, Biochemical pharmacology.

[14]  David I. Wilson,et al.  In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets , 2010, The Journal of endocrinology.

[15]  Ayellet V. Segrè,et al.  Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis , 2010, Nature Genetics.

[16]  H. Kang,et al.  Variance component model to account for sample structure in genome-wide association studies , 2010, Nature Genetics.

[17]  P. Bork,et al.  A method and server for predicting damaging missense mutations , 2010, Nature Methods.

[18]  T. Assimes,et al.  Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans , 2010, Diabetes.

[19]  Christian Gieger,et al.  New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , 2010, Nature Genetics.

[20]  Geoffrey S. Tobias,et al.  Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer , 2009, Nature Genetics.

[21]  M. Laakso,et al.  Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes With Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5,327 Nondiabetic Finnish Men , 2009, Diabetes.

[22]  Y. Wang,et al.  Kank proteins: structure, functions and diseases , 2009, Cellular and Molecular Life Sciences.

[23]  P. Halban,et al.  Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function. , 2009, Endocrinology.

[24]  Johanna Kuusisto,et al.  Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men , 2009, Diabetes.

[25]  M. Fukuda,et al.  Identification and characterization of a novel Tre‐2/Bub2/Cdc16 (TBC) protein that possesses Rab3A‐GAP activity , 2009, Genes to cells : devoted to molecular & cellular mechanisms.

[26]  R. Collins,et al.  Common variants at 30 loci contribute to polygenic dyslipidemia , 2009, Nature Genetics.

[27]  C. Hoggart,et al.  Genome-wide association analysis of metabolic traits in a birth cohort from a founder population , 2008, Nature Genetics.

[28]  L. Maquat,et al.  The multiple lives of NMD factors: balancing roles in gene and genome regulation , 2008, Nature Reviews Genetics.

[29]  B. Zinman,et al.  Hyperbolic Relationship Between Insulin Secretion and Sensitivity on Oral Glucose Tolerance Test , 2008, Obesity.

[30]  K. Shianna,et al.  Long-range LD can confound genome scans in admixed populations. , 2008, American journal of human genetics.

[31]  C. Haley,et al.  Genomewide Rapid Association Using Mixed Model and Regression: A Fast and Simple Method For Genomewide Pedigree-Based Quantitative Trait Loci Association Analysis , 2007, Genetics.

[32]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[33]  S. Minoshima,et al.  Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. , 2007, Genomics.

[34]  F. Barr,et al.  Functional dissection of Rab GTPases involved in primary cilium formation , 2007, The Journal of cell biology.

[35]  Yurii S. Aulchenko,et al.  BIOINFORMATICS APPLICATIONS NOTE doi:10.1093/bioinformatics/btm108 Genetics and population analysis GenABEL: an R library for genome-wide association analysis , 2022 .

[36]  D. Reich,et al.  Population Structure and Eigenanalysis , 2006, PLoS genetics.

[37]  J. Harrow,et al.  GENCODE: producing a reference annotation for ENCODE , 2006, Genome Biology.

[38]  Guy A Rutter,et al.  Insulin vesicle release: walk, kiss, pause ... then run. , 2006, Physiology.

[39]  R. Mains,et al.  Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. , 2005, Developmental biology.

[40]  R. Turner,et al.  Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man , 1985, Diabetologia.

[41]  B. Wicksteed,et al.  Insulin Secretory Deficiency and Glucose Intolerance in Rab3A Null Mice* , 2003, The Journal of Biological Chemistry.

[42]  R. Regazzi,et al.  The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells. , 2002, The Biochemical journal.

[43]  M. Stumvoll,et al.  Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. , 2001, Diabetes care.

[44]  K. Roeder,et al.  Genomic Control for Association Studies , 1999, Biometrics.

[45]  M. Matsuda,et al.  Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. , 1999, Diabetes care.

[46]  C. Wollheim,et al.  Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. , 1996, Journal of cell science.