Tolerogenic dendritic cells.

Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells. In peripheral lymphoid organs DCs also induce tolerance to antigens captured by receptors that mediate efficient uptake of proteins and dying cells. Uptake by these receptors leads to the constitutive presentation of antigens on major histocompatibility complex (MHC) class I and II products. In the steady state the targeting of DC antigen capture receptors with low doses of antigens leads to deletion of the corresponding T cells and unresponsiveness to antigenic rechallenge with strong adjuvants. In contrast, if a stimulus for DC maturation is coadministered with the antigen, the mice develop immunity, including interferon-gamma-secreting effector T cells and memory T cells. There is also new evidence that DCs can contribute to the expansion and differentiation of T cells that regulate or suppress other immune T cells. One possibility is that distinct developmental stages and subsets of DCs and T cells can account for the different pathways to peripheral tolerance, such as deletion or suppression. We suggest that several clinical situations, including autoimmunity and certain infectious diseases, can be influenced by the antigen-specific tolerogenic role of DCs.

[1]  Michel C. Nussenzweig,et al.  Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance , 2002, The Journal of experimental medicine.

[2]  D. Mevorach,et al.  Opsonization of Apoptotic Cells by Autologous iC3b Facilitates Clearance by Immature Dendritic Cells, Down-regulates DR and CD86, and Up-regulates CC Chemokine Receptor 7 , 2002, The Journal of experimental medicine.

[3]  Manuela Battaglia,et al.  Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells , 2002, The Journal of experimental medicine.

[4]  U. Grohmann,et al.  CTLA-4–Ig regulates tryptophan catabolism in vivo , 2002, Nature Immunology.

[5]  Ethan M. Shevach,et al.  Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node , 2002, The Journal of experimental medicine.

[6]  R. Steinman,et al.  Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ , 2002, The Journal of experimental medicine.

[7]  Scott N. Mueller,et al.  The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens , 2002, The Journal of experimental medicine.

[8]  A. Strasser,et al.  Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim , 2002, The Journal of experimental medicine.

[9]  C. Reis e Sousa,et al.  Cross‐presentation of cell‐associated antigens by CD8α+ dendritic cells is attributable to their ability to internalize dead cells , 2002, Immunology.

[10]  M. Dhodapkar,et al.  T cells from the tumor microenvironment of patients with progressive myeloma can generate strong, tumor-specific cytolytic responses to autologous, tumor-loaded dendritic cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[11]  D. Keskin,et al.  Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase , 2002, Science.

[12]  G. Berry,et al.  Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity , 2002, Nature Medicine.

[13]  M. Fortini,et al.  Signalling: γ-Secretase-mediated proteolysis in cell-surface-receptor signalling , 2002, Nature Reviews Molecular Cell Biology.

[14]  D. Toomre,et al.  Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane , 2002, Nature.

[15]  Jan Cerny,et al.  T-cell engagement of dendritic cells rapidly rearranges MHC class II transport , 2002, Nature.

[16]  K. Schäkel,et al.  The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting , 2002, The Journal of experimental medicine.

[17]  A. Sher,et al.  Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis , 2002, The Journal of experimental medicine.

[18]  Gerhard Opelz,et al.  Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells , 2002, The Journal of experimental medicine.

[19]  R. Steinman,et al.  Prolonged IFN-γ–producing NKT response induced with α-galactosylceramide–loaded DCs , 2002, Nature Immunology.

[20]  Steffen Jung,et al.  In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. , 2002, Immunity.

[21]  K. Legge,et al.  On the Role of Dendritic Cells in Peripheral T Cell Tolerance and Modulation of Autoimmunity , 2002, The Journal of experimental medicine.

[22]  L. Klein,et al.  Origin of regulatory T cells with known specificity for antigen , 2002, Nature Immunology.

[23]  L. Sherman,et al.  Memory CD8(+) T cells undergo peripheral tolerance. , 2002, Immunity.

[24]  L. Klein,et al.  Promiscuous gene expression and central T-cell tolerance: more than meets the eye. , 2002, Trends in immunology.

[25]  R. Steinman,et al.  Dendritic cells crossprime allo-specific self-restricted CD4(+) T cells after coculture with dead allogeneic cells. , 2002, Human immunology.

[26]  K. Rafiq,et al.  Immune complex-mediated antigen presentation induces tumor immunity. , 2002, The Journal of clinical investigation.

[27]  R. Steinman,et al.  Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans. , 2002, Blood.

[28]  J. Ravetch,et al.  Inducing Tumor Immunity through the Selective Engagement of Activating Fcγ Receptors on Dendritic Cells , 2002, The Journal of experimental medicine.

[29]  Kathleen M. Smith,et al.  Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP , 2002, Nature Immunology.

[30]  D. Green,et al.  Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness1 , 2002, The Journal of Immunology.

[31]  G. Schuler,et al.  Rapid Induction of Tumor-specific Type 1 T Helper Cells in Metastatic Melanoma Patients by Vaccination with Mature, Cryopreserved, Peptide-loaded Monocyte-derived Dendritic Cells , 2002, The Journal of experimental medicine.

[32]  R. Steinman,et al.  The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo , 2002, The Journal of experimental medicine.

[33]  C. Leclerc,et al.  CD8α2 CD11b+ Dendritic Cells Present Exogenous Virus-like Particles to CD8+ T Cells and Subsequently Express CD8α and CD205 Molecules , 2002, The Journal of experimental medicine.

[34]  B. Blazar,et al.  The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. , 2002, Blood.

[35]  A. Theofilopoulos,et al.  Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival. , 2002, The Journal of clinical investigation.

[36]  M. Nussenzweig,et al.  Mannose Receptor-Mediated Regulation of Serum Glycoprotein Homeostasis , 2002, Science.

[37]  David F. Richards,et al.  In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.

[38]  Antonio Lanzavecchia,et al.  The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells1 , 2002, The Journal of Immunology.

[39]  M. Colonna,et al.  Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4 , 2002, Nature Immunology.

[40]  A. Strasser,et al.  BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes , 2002, Nature.

[41]  N. Glaichenhaus,et al.  Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. , 2002, Immunity.

[42]  K. Mills,et al.  Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells , 2002, The Journal of experimental medicine.

[43]  G. Filomeni,et al.  Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[44]  M. Kaplan,et al.  Identification of HLA-A2–restricted CD8+ Cytotoxic T Cell Responses in Primary Biliary Cirrhosis , 2002, The Journal of Experimental Medicine.

[45]  C. Bogdan,et al.  Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor α Induce Antigen-specific Protection of Mice from Autoimmunity , 2002, The Journal of experimental medicine.

[46]  M. Dhodapkar,et al.  Antitumor Monoclonal Antibodies Enhance Cross-Presentation of Cellular Antigens and the Generation of Myeloma-specific Killer T Cells by Dendritic Cells , 2002, The Journal of experimental medicine.

[47]  Michel C. Nussenzweig,et al.  Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[48]  G. Trinchieri,et al.  Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. , 2002, The Journal of experimental medicine.

[49]  R. Steinman Inaugural Article : avoiding horror autotoxicus. The importance of dendritic cells in peripheral T cell tolerance , 2002 .

[50]  D. Keskin,et al.  Functional expression of indoleamine 2,3-dioxygenase by murine CD8α+ dendritic cells , 2002 .

[51]  Laurence Zitvogel,et al.  Antigen presentation and T cell stimulation by dendritic cells. , 2002, Annual review of immunology.

[52]  Philippa Marrack,et al.  T cells down-modulate peptide-MHC complexes on APCs in vivo , 2002, Nature Immunology.

[53]  A. Abbas,et al.  The enemy within: keeping self-reactive T cells at bay in the periphery , 2002, Nature Reviews Immunology.

[54]  Antonio Lanzavecchia,et al.  BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction , 2001, The Journal of experimental medicine.

[55]  Virginia Pascual,et al.  Induction of Dendritic Cell Differentiation by IFN-α in Systemic Lupus Erythematosus , 2001, Science.

[56]  J. Pin,et al.  Immature Human Dendritic Cells Express Asialoglycoprotein Receptor Isoforms for Efficient Receptor-Mediated Endocytosis1 , 2001, The Journal of Immunology.

[57]  Michel C. Nussenzweig,et al.  Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo , 2001, The Journal of experimental medicine.

[58]  Javier Hernández,et al.  Phenotypic and Functional Analysis of Cd8+ T Cells Undergoing Peripheral Deletion in Response to Cross-Presentation of Self-Antigen , 2001, The Journal of experimental medicine.

[59]  T. Luger,et al.  Overexpression of Cd40 Ligand in Murine Epidermis Results in Chronic Skin Inflammation and Systemic Autoimmunity , 2001, The Journal of experimental medicine.

[60]  Maria Persico,et al.  Inducible IL-2 production by dendritic cells revealed by global gene expression analysis , 2001, Nature Immunology.

[61]  R. Steinman,et al.  Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine. , 2001, Cancer research.

[62]  T. Laufer,et al.  Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells , 2001, The Journal of experimental medicine.

[63]  Y. Liu,et al.  Dendritic Cell Subsets and Lineages, and Their Functions in Innate and Adaptive Immunity , 2001, Cell.

[64]  P. Borrow,et al.  The Host-Pathogen Interaction New Themes from Dendritic Cell Biology , 2001, Cell.

[65]  D. Umetsu,et al.  Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen , 2001, Nature Immunology.

[66]  M. Roncarolo,et al.  Type 1 T regulatory cells , 2001, Immunological reviews.

[67]  C. Uyttenhove,et al.  IL-6 Inhibits the Tolerogenic Function of CD8α+ Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase1 , 2001, The Journal of Immunology.

[68]  J. Banchereau,et al.  Sensing Pathogens and Tuning Immune Responses , 2001, Science.

[69]  F. Sallusto,et al.  The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. , 2001, Current opinion in immunology.

[70]  F. Powrie,et al.  CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice1 , 2001, The Journal of Immunology.

[71]  R. de Waal Malefyt,et al.  IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells1 , 2001, The Journal of Immunology.

[72]  R. Steinman,et al.  Dendritic cells in transplantation--friend or foe? , 2001, Immunity.

[73]  Giampiero Girolomoni,et al.  Regulatory Activity of Autocrine IL-10 on Dendritic Cell Functions1 , 2001, The Journal of Immunology.

[74]  N A Mitchison,et al.  Tolerance and Autoimmunity , 2001 .

[75]  R. Steinman,et al.  Brief Definitive Report Dendritic Cells Cross-present Latency Gene Products from Epstein-barr Virus–transformed B Cells and Expand Tumor-reactive Cd8 Ϩ Killer T Cells , 2022 .

[76]  C. Kurts,et al.  Cutting Edge: Dendritic Cells Are Sufficient to Cross-Present Self-Antigens to CD8 T Cells In Vivo1 , 2001, The Journal of Immunology.

[77]  Nina Bhardwaj,et al.  Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells , 2001, The Journal of experimental medicine.

[78]  R. Pauwels,et al.  Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes , 2001, The Journal of experimental medicine.

[79]  W. Heath,et al.  Cross-presentation, dendritic cells, tolerance and immunity. , 2001, Annual review of immunology.

[80]  C. Kurts,et al.  Dendritic cells are sufficient to cross-present self-antigens to CD8 T cells in vivo. , 2001, Journal of immunology.

[81]  M. Jordan Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.

[82]  A. Palucka,et al.  Cross-Priming of Naive Cd8 T Cells against Melanoma Antigens Using Dendritic Cells Loaded with Killed Allogeneic Melanoma Cells , 2000, The Journal of experimental medicine.

[83]  P. Kourilsky,et al.  Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. , 2000, Immunity.

[84]  R. Vabulas,et al.  Bacterial CpG‐DNA activates dendritic cells in vivo: T helper cell‐independent cytotoxic T cell responses to soluble proteins , 2000, European journal of immunology.

[85]  A. Enk,et al.  Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells , 2000, The Journal of experimental medicine.

[86]  M. Bagot,et al.  Triggering CD101 molecule on human cutaneous dendritic cells inhibits T cell proliferation via IL‐10 production , 2000, European journal of immunology.

[87]  J. Abastado,et al.  Incoming Human Cytomegalovirus pp65 (UL83) Contained in Apoptotic Infected Fibroblasts Is Cross-Presented to CD8+ T Cells by Dendritic Cells , 2000, Journal of Virology.

[88]  R. Steinman,et al.  The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments , 2000, The Journal of cell biology.

[89]  F. Sallusto,et al.  Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells , 2000, Nature Immunology.

[90]  A. Enk,et al.  Mage-3 and Influenza-Matrix Peptide-Specific Cytotoxic T Cells Are Inducible in Terminal Stage HLA-A2.1+ Melanoma Patients by Mature Monocyte-Derived Dendritic Cells1 , 2000, The Journal of Immunology.

[91]  R. Steinman,et al.  A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. , 2000, Human immunology.

[92]  P. Ricciardi-Castagnoli,et al.  Immature Dendritic Cells Acquire Cd8+Cytotoxic T Lymphocyte Priming Capacity upon Activation by T Helper Cell–Independent or–Dependent Stimuli , 2000, The Journal of experimental medicine.

[93]  S. Sakaguchi Regulatory T cells , 2006, Springer Seminars in Immunopathology.

[94]  R. Steinman,et al.  Human Cd4+ T Lymphocytes Consistently Respond to the Latent Epstein-Barr Virus Nuclear Antigen Ebna1 , 2000, The Journal of experimental medicine.

[95]  R. Steinman,et al.  Transport of peptide-MHC class II complexes in developing dendritic cells. , 2000, Science.

[96]  M. Nussenzweig,et al.  Crystal Structure of the Cysteine-Rich Domain of Mannose Receptor Complexed with a Sulfated Carbohydrate Ligand , 2000, The Journal of experimental medicine.

[97]  Milton W. Taylor,et al.  Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation , 2000, The Journal of Immunology.

[98]  Ira Mellman,et al.  The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli , 2000, The Journal of experimental medicine.

[99]  R. Steinman,et al.  Mature dendritic cells boost functionally superior CD8(+) T-cell in humans without foreign helper epitopes. , 2000, The Journal of clinical investigation.

[100]  C. Figdor,et al.  Identification of DC-SIGN, a Novel Dendritic Cell–Specific ICAM-3 Receptor that Supports Primary Immune Responses , 2000, Cell.

[101]  U. Yrlid,et al.  Salmonella-Induced Apoptosis of Infected Macrophages Results in Presentation of a Bacteria-Encoded Antigen after Uptake by Bystander Dendritic Cells , 2000, The Journal of experimental medicine.

[102]  F. Huang,et al.  A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes , 2000, The Journal of experimental medicine.

[103]  R. Steinman,et al.  The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells , 2000, The Journal of experimental medicine.

[104]  C Caux,et al.  Immunobiology of dendritic cells. , 2000, Annual review of immunology.

[105]  J. Davoust,et al.  Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. , 2000, Immunity.

[106]  E. Shevach Regulatory T cells in autoimmmunity*. , 2000, Annual review of immunology.

[107]  A. Enk,et al.  Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma , 1999, The Journal of experimental medicine.

[108]  R. Steinman,et al.  Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo. , 1999, Immunity.

[109]  Sebastian Amigorena,et al.  Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells , 1999, Nature Cell Biology.

[110]  A. Iwasaki,et al.  Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells , 1999, The Journal of experimental medicine.

[111]  L. Sherman,et al.  Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens. , 1999, Journal of immunology.

[112]  R. Steinman,et al.  Rapid generation of broad T-cell immunity in humans after a single injection of mature dendritic cells. , 1999, The Journal of clinical investigation.

[113]  S. Gordon,et al.  Mannose Receptor and Its Putative Ligands in Normal Murine Lymphoid and Nonlymphoid Organs: In Situ Expression of Mannose Receptor by Selected Macrophages, Endothelial Cells, Perivascular Microglia, and Mesangial Cells, but not Dendritic Cells , 1999, The Journal of experimental medicine.

[114]  Antonio Lanzavecchia,et al.  Distinct patterns and kinetics of chemokine production regulate dendritic cell function , 1999, European journal of immunology.

[115]  L. Glimcher,et al.  Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo. , 1999, Journal of immunology.

[116]  P. Ricciardi-Castagnoli,et al.  Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo , 1999, Nature Medicine.

[117]  R. Maldonado-López,et al.  CD8α+ and CD8α− Subclasses of Dendritic Cells Direct the Development of Distinct T Helper Cells In Vivo , 1999, The Journal of experimental medicine.

[118]  P. Ricciardi-Castagnoli,et al.  Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization , 1999, The Journal of experimental medicine.

[119]  B. Stockinger,et al.  DNA Vaccination:  Transfection and Activation of Dendritic Cells as Key Events for Immunity , 1999, The Journal of experimental medicine.

[120]  R. Steinman,et al.  Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells , 1998, The Journal of experimental medicine.

[121]  D. Mason,et al.  Control of immune pathology by regulatory T cells. , 1998, Current opinion in immunology.

[122]  R. Steinman,et al.  Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. , 1998, Science.

[123]  Loise M. Francisco,et al.  Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes , 1998, The Journal of experimental medicine.

[124]  L. Klein,et al.  CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium , 1998, The Journal of experimental medicine.

[125]  R. Zinkernagel,et al.  Dendritic Cells Efficiently Induce Protective Antiviral Immunity , 1998, Journal of Virology.

[126]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[127]  A. Sher,et al.  In Vivo Microbial Stimulation Induces Rapid CD40 Ligand–independent Production of Interleukin 12 by Dendritic Cells and their Redistribution to T Cell Areas , 1997, The Journal of experimental medicine.

[128]  C. Kurts,et al.  Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells , 1997, The Journal of experimental medicine.

[129]  V. Verhasselt,et al.  Interleukin‐10 prevents the generation of dendritic cells from human peripheral blood mononuclear cells cultured with interleukin‐4 and granulocyte/ macrophage‐colony‐stimulating factor , 1997, European journal of immunology.

[130]  M. Riedinger,et al.  Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo , 1997, The Journal of experimental medicine.

[131]  T. Zal,et al.  Antigen-presenting cells in the thymus that can negatively select MHC class II-restricted T cells recognizing a circulating self antigen. , 1997, Journal of Immunology.

[132]  D. Niederwieser,et al.  Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. , 1996, Journal of immunological methods.

[133]  P. De Baetselier,et al.  Regulation of Dendritic Cell Numbers and Maturation by Lipopolysaccharide in Vivo , 1996 .

[134]  R. Steinman,et al.  Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. , 1996, Journal of immunological methods.

[135]  L. Glimcher,et al.  Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex , 1996, Nature.

[136]  J. Miller,et al.  Constitutive class I-restricted exogenous presentation of self antigens in vivo , 1996, The Journal of experimental medicine.

[137]  G. Schuler,et al.  High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10 [published erratum appears in J Exp Med 1996 Oct 1;184(4):following 1590] , 1996, The Journal of experimental medicine.

[138]  A. Lanzavecchia,et al.  Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation , 1996, The Journal of experimental medicine.

[139]  K. Shokat,et al.  Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[140]  G. Schuler,et al.  Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. , 1997, Advances in experimental medicine and biology.

[141]  L. Zitvogel,et al.  Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity , 1995, Nature Medicine.

[142]  R. Steinman,et al.  DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization, and N-terminal amino acid sequence. , 1995, Cellular immunology.

[143]  C Danieli,et al.  Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products , 1995, The Journal of experimental medicine.

[144]  H. Pircher,et al.  T cell priming versus T cell tolerance induced by synthetic peptides , 1995, The Journal of experimental medicine.

[145]  R. Steinman,et al.  The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing , 1995, Nature.

[146]  B. Stockinger,et al.  Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen , 1994, The Journal of experimental medicine.

[147]  R. Steinman,et al.  The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro , 1994, The Journal of experimental medicine.

[148]  J. Banchereau,et al.  Activation of human dendritic cells through CD40 cross-linking , 1994, The Journal of experimental medicine.

[149]  D. Loh,et al.  Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. , 1994, Immunity.

[150]  F. Sallusto,et al.  Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha , 1994, The Journal of experimental medicine.

[151]  R. de Waal Malefyt,et al.  High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells , 1994, The Journal of experimental medicine.

[152]  H. Pircher,et al.  Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[153]  Hans Hengartner,et al.  T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides , 1993, European journal of immunology.

[154]  R. Steinman,et al.  Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo , 1993, The Journal of experimental medicine.

[155]  G. Macpherson,et al.  Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo , 1993, The Journal of experimental medicine.

[156]  R. Steinman,et al.  Two populations of splenic dendritic cells detected with M342, a new monoclonal to an intracellular antigen of interdigitating dendritic cells and some B lymphocytes , 1992, Journal of leukocyte biology.

[157]  C. Benoist,et al.  The thymic compartment responsible for positive selection of CD4+ T cells. , 1992, International immunology.

[158]  M. Nerenberg,et al.  Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response , 1991, Cell.

[159]  H. Pircher,et al.  Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice , 1991, Cell.

[160]  B. Rocha,et al.  Peripheral selection of the T cell repertoire. , 1991, Science.

[161]  D. Longo,et al.  Peripheral clonal elimination of functional T cells. , 1990, Science.

[162]  P. Bailly,et al.  Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells , 1990, The Journal of experimental medicine.

[163]  R. Steinman,et al.  Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen. , 1990, Journal of immunological methods.

[164]  R. Steinman,et al.  Dendritic cells pulsed with protein antigens in vitro can prime antigen- specific, MHC-restricted T cells in situ [published erratum appears in J Exp Med 1990 Oct 1;172(4):1275] , 1990, The Journal of experimental medicine.

[165]  M. Taylor,et al.  Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. , 1990, The Journal of biological chemistry.

[166]  R. Steinman,et al.  Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins , 1990, The Journal of experimental medicine.

[167]  R. Steinman,et al.  The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies , 1990, The Journal of experimental medicine.

[168]  P. Fairchild,et al.  Thymic dendritic cells: phenotype and function. , 1990, International reviews of immunology.

[169]  B. Dutia,et al.  Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage , 1989, The Journal of experimental medicine.

[170]  Polly Matzinger,et al.  Does T-cell tolerance require a dedicated antigen-presenting cell? , 1989, Nature.

[171]  R. Zinkernagel,et al.  Deletion of self-reactive T cells before entry into the thymus medulla , 1988, Nature.

[172]  R. Zinkernagel,et al.  Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens , 1988, The Journal of experimental medicine.

[173]  P. Holt,et al.  MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat. Regulation of antigen presentation activity by endogenous macrophage populations , 1988, The Journal of experimental medicine.

[174]  R. Steinman,et al.  Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes , 1986, The Journal of experimental medicine.

[175]  G. Kraal,et al.  Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody , 1986, The Journal of experimental medicine.

[176]  R. Steinman,et al.  Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro , 1985, The Journal of experimental medicine.

[177]  C. Pugh,et al.  Characterization of nonlymphoid cells derived from rat peripheral lymph , 1983, The Journal of experimental medicine.

[178]  M. Rechsteiner,et al.  Introduction of macromolecules into cultured mammalian cells by osmotic lysis of pinocytic vesicles , 1982, Cell.

[179]  G. Mayrhofer,et al.  Bone marrow origin of Ia-positive cells in the medulla rat thymus , 1981, The Journal of experimental medicine.

[180]  P. Schlesinger,et al.  Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling , 1980, Cell.

[181]  P. Medawar,et al.  ‘Actively Acquired Tolerance’ of Foreign Cells , 1953, Nature.