Radiographic changes associated with tracheal isolation of Ureaplasma urealyticum from neonates.

Recent studies show an association between the presence of Ureaplasma urealyticum in tracheal aspirates and bronchopulmonary dysplasia. We hypothesized that among infants with birth weights < or = 1,250 g and respiratory disease, those with U. urealyticum in their tracheal aspirates would have radiographic evidence of more-severe pulmonary disease more often than would those without this organism. A total of 292 low-birth-weight infants who had endotracheal aspirate cultured within 7 days of birth were enrolled. The radiographic outcome variables were pneumonia, early severe bronchopulmonary dysplasia (precocious), and chronic lung disease. Microorganisms were isolated from 128 infants (44%); U. urealyticum was isolated from 44 (15%). Pneumonia was significantly more common in infants with than without U. urealyticum (30% vs. 16%, P = .03). U. urealyticum also was associated with precocious bronchopulmonary dysplasia independent of prematurity, race, and sex (odds ratio, 2.2; P < .05). Tracheal isolation of U. urealyticum within 7 days of birth is associated with pneumonia and precocious bronchopulmonary dysplasia.

[1]  J D Horbar,et al.  Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Network. , 1991, Pediatrics.

[2]  Y. Lau,et al.  Sensitivity and specificity of daily tracheal aspirate cultures in predicting organisms causing bacteremia in ventilated neonates , 1991, The Pediatric infectious disease journal.

[3]  G. Cassady,et al.  Hyperoxia potentiates Ureaplasma urealyticum pneumonia in newborn mice , 1990, Infection and immunity.

[4]  W. Northway.  Bronchopulmonary dysplasia: then and now. , 1990, Archives of disease in childhood.

[5]  A. Jensen,et al.  Chest X‐ray Appearances in Pneumonia and Bronchiolitis , 1990, Acta paediatrica Scandinavica.

[6]  S. Abman,et al.  Late sudden unexpected deaths in hospitalized infants with bronchopulmonary dysplasia. , 1989, American journal of diseases of children.

[7]  K. Waites,et al.  Ureaplasma urealyticum pneumonia: experimental production and demonstration of age-related susceptibility , 1989, Infection and immunity.

[8]  K. Waites,et al.  Ureaplasmal pneumonia and sepsis associated with persistent pulmonary hypertension of the newborn. , 1989, Pediatrics.

[9]  E. Wang,et al.  Role of Ureaplasma urealyticum and other pathogens in the development of chronic lung disease of prematurity. , 1988, The Pediatric infectious disease journal.

[10]  P. Sánchez,et al.  Ureaplasma urealyticum colonization and chronic lung disease in low birth weight infants. , 1988, The Pediatric infectious disease journal.

[11]  G. Cassell,et al.  ASSOCIATION OF UREAPLASMA UREALYTICUM INFECTION OF THE LOWER RESPIRATORY TRACT WITH CHRONIC LUNG DISEASE AND DEATH IN VERY-LOW-BIRTH-WEIGHT INFANTS , 1988, The Lancet.

[12]  T. Keens,et al.  Childhood sequelae of infant lung disease: exercise and pulmonary function abnormalities after bronchopulmonary dysplasia. , 1987, The Journal of pediatrics.

[13]  S. Spector,et al.  Cytomegalovirus infection and bronchopulmonary dysplasia in premature infants. , 1987, American journal of diseases of children.

[14]  D. Reed,et al.  Identification of Mycoplasmatales in pneumonic calf lungs. , 1986, Veterinary microbiology.

[15]  D. Singer,et al.  Neonatal sepsis due to nontypable Haemophilus influenzae. , 1986, American journal of diseases of children.

[16]  M. S. St John,et al.  Intrauterine infection with Ureaplasma urealyticum as a cause of fatal neonatal pneumonia , 1985, Pediatric infectious disease.

[17]  R. Mellins,et al.  Bronchopulmonary dysplasia. Unresolved neonatal acute lung injury. , 1985, The American review of respiratory disease.

[18]  R. Wennberg,et al.  Tracheal asiration and its clinical correlates in the diagnosis of congenital pneumonia. , 1980, Pediatrics.

[19]  E. Brown.  Increased risk of bronchopulmonary dysplasia in infants with patent ductus arteriosus. , 1979, The Journal of pediatrics.

[20]  E. Effmann,et al.  The radiographic features of early onset Group B streptococcal neonatal sepsis. , 1977, Radiology.

[21]  G. Cassady,et al.  Endotracheal intubation and its relationship to bacterial colonization and systemic infection of newborn infants. , 1976, Pediatrics.

[22]  C. Howard,et al.  Induction of pneumonia in gnotobiotic calves following inoculation of Mycoplasma dispar and ureaplasmas (T-mycoplasmas). , 1976, Research in veterinary science.

[23]  E. Effmann,et al.  A comparison of early-onset group B steptococcal neonatal infection and the respiratory-distress syndrome of the newborn. , 1976, The New England journal of medicine.

[24]  W. Northway,et al.  Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. , 1967, The New England journal of medicine.

[25]  R. Riegelman.  Studying a Study and Testing a Test: How to Read the Medical Literature , 1981 .

[26]  R. Steiner,et al.  The value of radiology in the idiopathic respiratory distress syndrome: a radiological and pathological correlation study. , 1976, Clinical radiology.