EGFR activation-induced decreases in claudin1 promote MUC5AC expression and exacerbate asthma in mice

[1]  A. Andiappan,et al.  Role of IL-13Ra2 in modulating IL-13 induced MUC5AC and ciliary changes in healthy and CRSwNP mucosa , 2019, Airway cell biology and immunopathology.

[2]  Y. Gon,et al.  Role of airway epithelial barrier dysfunction in pathogenesis of asthma. , 2018, Allergology international : official journal of the Japanese Society of Allergology.

[3]  Jiao Song,et al.  The Chronic and Short-Term Effects of Gefinitib on Airway Remodeling and Inflammation in a Mouse Model of Asthma , 2016, Cellular Physiology and Biochemistry.

[4]  H. Vliagoftis,et al.  Airway Epithelium Interactions with Aeroallergens: Role of Secreted Cytokines and Chemokines in Innate Immunity , 2015, Front. Immunol..

[5]  D. Schwartz,et al.  The polymeric mucin Muc5ac is required for allergic airway hyperreactivity , 2015, Nature Communications.

[6]  R. Crystal Airway basal cells. The "smoking gun" of chronic obstructive pulmonary disease. , 2014, American journal of respiratory and critical care medicine.

[7]  S. Georas,et al.  Epithelial barrier function: at the front line of asthma immunology and allergic airway inflammation. , 2014, The Journal of allergy and clinical immunology.

[8]  D. Sheppard,et al.  The cell biology of asthma , 2014, The Journal of cell biology.

[9]  P. Howarth,et al.  TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation. , 2013, The Journal of allergy and clinical immunology.

[10]  A. Yu,et al.  Claudins and the modulation of tight junction permeability. , 2013, Physiological reviews.

[11]  S. Georas,et al.  Interleukin-4 and interleukin-13 cause barrier dysfunction in human airway epithelial cells , 2013, Tissue barriers.

[12]  H. Tsutsumi,et al.  Regulation of Tight Junctions in Upper Airway Epithelium , 2012, BioMed research international.

[13]  M. Castro,et al.  Immune responses to self-antigens in asthma patients: clinical and immunopathological implications. , 2012, Human immunology.

[14]  Hideki Chiba,et al.  Possible Involvement of Tight Junctions, Extracellular Matrix and Nuclear Receptors in Epithelial Differentiation , 2011, Journal of biomedicine & biotechnology.

[15]  Y. Soini Claudins in lung diseases , 2011, Respiratory research.

[16]  Douglas C Johnson,et al.  Airway mucus function and dysfunction. , 2011, The New England journal of medicine.

[17]  J. Whitsett,et al.  Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. , 2011, American journal of physiology. Lung cellular and molecular physiology.

[18]  Y. Okayama,et al.  Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack. , 2009, The Journal of allergy and clinical immunology.

[19]  S. Muller,et al.  Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. , 2009, American journal of respiratory and critical care medicine.

[20]  J. Nadel,et al.  Fibrinogen binding to ICAM-1 promotes EGFR-dependent mucin production in human airway epithelial cells. , 2009, American journal of physiology. Lung cellular and molecular physiology.

[21]  Wai-ming Lee,et al.  Rhinovirus-induced Major Airway Mucin Production Involves a Novel Tlr3-egfr–dependent Pathway , 2009 .

[22]  M. Balda,et al.  Tight junctions and the regulation of gene expression. , 2009, Biochimica et biophysica acta.

[23]  Kyubo Kim,et al.  Mucus hypersecretion in asthma: causes and effects , 2009, Current opinion in pulmonary medicine.

[24]  H. Hoogsteden,et al.  Altered expression of epithelial junctional proteins in atopic asthma: possible role in inflammation. , 2008, Canadian journal of physiology and pharmacology.

[25]  S. Holgate Epithelium dysfunction in asthma. , 2007, The Journal of allergy and clinical immunology.

[26]  Eun Joo Lee,et al.  Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation , 2007, Experimental & Molecular Medicine.

[27]  L. Cohn Mucus in chronic airway diseases: sorting out the sticky details. , 2006, The Journal of clinical investigation.

[28]  B. Stripp,et al.  Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. , 2004, American journal of respiratory cell and molecular biology.

[29]  E. Gelfand,et al.  Histopathology of severe childhood asthma: a case series. , 2003, Chest.

[30]  J. Fahy Goblet cell and mucin gene abnormalities in asthma. , 2002, Chest.

[31]  D. Thornton,et al.  Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. , 2002, The Biochemical journal.

[32]  P. Howarth,et al.  Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. , 2001, American journal of respiratory cell and molecular biology.

[33]  P. Howarth,et al.  Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects. , 2002, The Journal of allergy and clinical immunology.

[34]  P. Burgel,et al.  The role of epidermal growth factor in mucus production. , 2001, Current opinion in pharmacology.

[35]  J. Nadel Role of epidermal growth factor receptor activation in regulating mucin synthesis , 2001, Respiratory research.

[36]  J. Nadel,et al.  Relationship of epidermal growth factor receptors to goblet cell production in human bronchi. , 2001, American journal of respiratory and critical care medicine.

[37]  R. Wu,et al.  Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression. , 2001, American journal of respiratory and critical care medicine.

[38]  K. Fujimoto,et al.  A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts , 1998, The Journal of cell biology.

[39]  Y. Nasuhara,et al.  Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway. , 1998, American journal of respiratory and critical care medicine.

[40]  K. Shirato,et al.  Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma. , 1996, The European respiratory journal.

[41]  D. Rogers,et al.  Airway goblet cells: responsive and adaptable front-line defenders. , 1994, The European respiratory journal.