New roles for old holes: ion channel function in aquaporin-1.

Mammalian aquaporins are part of the diverse major intrinsic protein family of water and solute channels. Intriguing links exist in structural and functional properties between aquaporins and ion channels. A novel role for aquaporin-1 as a gated ion channel reshapes our current views of this ancient family of transmembrane channel proteins.

[1]  E. Frömter.  Viewing the kidney through microelectrodes , 1984 .

[2]  B. Chait,et al.  The structure of the potassium channel: molecular basis of K+ conduction and selectivity. , 1998, Science.

[3]  J. Regan,et al.  Cloned human aquaporin-1 is a cyclic GMP-gated ion channel. , 2000, Molecular pharmacology.

[4]  D. Baylor,et al.  Gating kinetics of the cyclic-GMP-activated channel of retinal rods: flash photolysis and voltage-jump studies. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[5]  P. Pohl,et al.  Water and Ion Permeation of Aquaporin-1 in Planar Lipid Bilayers , 2001, The Journal of Biological Chemistry.

[6]  P. Agre,et al.  Quantification of Aquaporin-CHIP water channel protein in microdissected renal tubules by fluorescence-based ELISA. , 1995, The Journal of clinical investigation.

[7]  D. Fu,et al.  Structure of a glycerol-conducting channel and the basis for its selectivity. , 2000, Science.

[8]  R. MacKinnon,et al.  Mutations in the K+ channel signature sequence. , 1994, Biophysical journal.

[9]  R. Miledi,et al.  Effects of defolliculation on membrane current responses of Xenopus oocytes. , 1989, The Journal of physiology.

[10]  T. Wang.  Nitric oxide regulates HCO3- and Na+ transport by a cGMP-mediated mechanism in the kidney proximal tubule. , 1997, The American journal of physiology.

[11]  Andreas Engel,et al.  Structural determinants of water permeation through aquaporin-1 , 2000, Nature.

[12]  J. Regan,et al.  Inhibition of aquaporin-1 water permeability by tetraethylammonium: involvement of the loop E pore region. , 2000, Molecular pharmacology.

[13]  Chad A. Cowan,et al.  EphB2 Guides Axons at the Midline and Is Necessary for Normal Vestibular Function , 2000, Neuron.

[14]  A Cheng,et al.  Visualization of a water-selective pore by electron crystallography in vitreous ice. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[15]  J. Regan,et al.  Forskolin Stimulation of Water and Cation Permeability in Aquaporin1 Water Channels , 1996, Science.

[16]  Y. Jan,et al.  Structural elements involved in specific K+ channel functions. , 1992, Annual review of physiology.

[17]  R. Blantz,et al.  Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat. , 1992, The Journal of clinical investigation.

[18]  D. Hary,et al.  Replay of Hippocampal "Memories" , 1996, Science.